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Journal of Radiation Research and Applied Sciences
ISSN 2314-7164 · Elsevier · 925 artikel di indeks
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Artikel Jurnal
Efficacy and prognostic value of continuous veno-venous hemofiltration combined with CPFA in sepsis-associated acute kidney injury based on perirenal CT imaging features
Objective: This study aimed to preliminarily evaluate and compare the efficacy of continuous veno-venous hemofiltration (CVVH) combined with continuous plasma filtration and adsorption (CPFA) versus CVVH monotherapy based on CT imaging features with multidimensional indicators, and to exploratorily…
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Artikel Jurnal
Efficacy of percutaneous vertebroplasty for osteoporotic vertebral compression fractures diagnosed by MRI: A meta-analysis
Objective: This meta-analysis was aimed to systematically compare the efficacy between percutaneous vertebroplasty (PVP) and conservative treatment in the patients with osteoporotic vertebral compression fractures (OVCFs) complicated by bone marrow edema as diagnosed by magnetic resonance imaging…
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Artikel Jurnal
MicroRNA-based therapies for ovarian cancer enhanced by ultrasound-targeted microbubble destruction: Mechanistic basis, preclinical evidence, and translational challenges
Background: Ovarian cancer remains a lethal gynecologic malignancy because of late presentation, recurrence, and treatment resistance. MicroRNA (miRNA)-based therapeutics can modulate multiple oncogenic pathways, but clinical development is constrained by nuclease degradation, non-specific…
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Artikel Jurnal
Raloxifene as a candidate intestinal UGT1A probe during irinotecan-based chemotherapy: an open-label, two-cohort pilot pharmacokinetic and short-term safety study
Objective: Preclinical studies suggested that raloxifene (Ral) metabolite-to-parent ratios may reflect intestinal UGT1A activity during irinotecan-induced intestinal injury, but clinical feasibility and short-term safety remain unclear. This open-label, two-cohort pilot study aimed to evaluate the…
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Artikel Jurnal
AICD-associated MMP1 in ovarian cancer: Prognostic, spatial, and functional evidence
Background: Ammonia-induced cell death (AICD) is a recently described form of regulated cell death, but the clinical relevance of AICD-associated genes in ovarian cancer remains unclear. Methods: Transcriptomic and clinical data from TCGA-OV and four GEO cohorts were used to evaluate…
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Artikel Jurnal
A new efficient power ratio-cum-regression estimators with Monte Carlo simulation: Statistical analysis of the radiation, accounting, and transportation data
This paper proposes an efficient power ratio-cum-regression estimator to estimate the distribution function of a finite population based on the simple random sampling scheme with auxiliary information. The proposed estimator combines ratio and regression-type components in a single consistent…
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Artikel Jurnal
An integrated immune-related signature reveals prognostic and immune–microbiome–genomic interactions in head and neck squamous cell carcinoma
Background: Head and neck squamous cell carcinoma (HNSCC) is characterized by substantial biological diversity and heterogeneous clinical outcomes. Immune-based therapies have improved treatment options for some patients; however, reliable biomarkers capable of accurately defining patient risk and…
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Artikel Jurnal
Predictive value of echocardiography combined with hemoglobin level for left ventricular outflow tract obstruction in hypertrophic cardiomyopathy
Objective: This study aimed to explore the ability of ultrasonic parameters combined with hemoglobin (HGB) levels to predict the subsequent development of left ventricular outflow tract obstruction (LVOTO) in patients with hypertrophic cardiomyopathy (HCM). Methods: A retrospective study of 333…
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Artikel Jurnal
An improved estimation technique with mathematical foundation: Its applications in physical education, accounting and radiation analytics
The use of auxiliary information is a long-standing technique in survey sampling to improve the precision of estimating population parameters. If auxiliary variables are highly correlated with the study variable, then the sample mean from an SRSWOR is typically not the best estimator. The…
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Artikel Jurnal
Ipsilateral hemilaminectomy via unilateral biportal endoscopy for two-level lumbar spinal stenosis: A finite element analysis and retrospective clinical study
Background: The optimal minimally invasive strategy for contiguous two-level central lumbar stenosis is uncertain. We evaluated two-incision unilateral biportal endoscopy (UBE) ipsilateral hemilaminectomy using finite-element (FE) and clinical analyses. Methods: A single-subject L2–S1 FE model…
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Artikel Jurnal
Cancer associated fibroblast-related lactate metabolism promotes cisplatin resistance in colorectal cancer by enhancing NBS1 transcription via H3K18 lactylation
Background: Cancer-associated fibroblasts (CAFs) secrete abundant lactate and drive chemoresistance in colorectal cancer (CRC). This study investigates the epigenetic mechanisms, focusing on histone lactylation and transcriptional regulation of Nijmegen breakage syndrome 1 (NBS1). Methods: Clinical…
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Artikel Jurnal
Effects of LncRNA-MEG3 regulating ZEB2 expression on biological behaviors of triple-negative breast cancer
Objective: This work aimed to investigate whether lncRNA-MEG3 regulates ZEB2 expression and thereby modulates proliferation, migration, and apoptosis in triple-negative breast cancer tissues and primary TNBC cells. Methods: MEG3 and ZEB2 expression were measured by RT-PCR and Western blot in…
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Artikel Jurnal
Semi-quantitative ultrasound scoring reveals hepatic structural recovery and immune modulation during tenofovir alafenamide therapy in chronic hepatitis B
Objective: This study aimed to evaluate the therapeutic response to tenofovir alafenamide fumarate (TAF) in chronic hepatitis B (CHB) using a semi-quantitative ultrasound (US) scoring system, and to investigate the correlation between sonographic changes and immune function restoration. Methods: A…
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Artikel Jurnal
Exosomal lncRNA PVT1 from adipose-derived stem cell aggravates myocardial injury through CDC25A/PI3Kγ/NF-κB pathway under high glucose condition
Diabetic cardiomyopathy (DCM) is an important cardiovascular complication of diabetes. However, the pathogenesis of myocardial injury in DCM is still unclear. In-depth exploration of the pathogenesis of myocardial injury in DCM is helpful for drug target screening and clinical treatment of DCM…
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Artikel Jurnal
Oleanolic acid improves intestinal inflammation and fibrosis in Crohn's disease via regulation the target of PPAR-γ based on network pharmacology analysis combined with experimental validation
Background: As a form of chronic inflammatory bowel disease, crohn's disease (CD) is a condition in which intestinal fibrosis is a defining characteristic. Oleanolic acid (OA), as a naturally occurring pentacyclic triterpenoid compound, has gradually been applied in the research of disease…
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Artikel Jurnal
The value of magnetic resonance imaging dynamic contrast-enhanced and diffusion-weighted imaging in assessing villous VEGF expression and trophoblastic invasive activity in early tubal pregnancy
Objective: This retrospective study tested the value of magnetic resonance imaging (MRI) dynamic enhancement and diffusion-weighted imaging (DWI) for evaluating villous vascular endothelial growth factor (VEGF) expression in early tubal pregnancy. The biological activity of the trophoblast is…
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Artikel Jurnal
X-ray attenuation and dielectric response of MnFe2O4/NiO@PVA/PEG films within the medical diagnostic X-ray range
Lead aprons remain standard in diagnostic radiology despite their weight and toxicity. In this study, PVA/PEG films containing 15.52 wt% MnFe2O4/NiO nanocomposite were prepared by solution casting and compared with the undoped blend. The films were evaluated by XRD, TEM/SEM, TGA, dielectric…
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Artikel Jurnal
Comparative evaluation of mass attenuation coefficients and energy absorption parameters in human tissues across a broad photon energy range
Reliable photon attenuation data are fundamental to medical physics for characterizing radiation transport, dose deposition, and shielding requirements within biological media. This study provides a comprehensive evaluation of the mass attenuation coefficient (MAC) across twelve human tissues…
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Artikel Jurnal
Lactate-associated H3K18 lactylation and METTL3/YTHDC1 signaling promote ACSL4-linked ferroptotic injury in the septic intestine
Background: The intestinal injury induced by sepsis prompts the poor prognosis of critically ill patients, and lactate accumulation exerts influences on the progression of sepsis. This study aims to elucidate the molecular mechanism by which lactate-induced histone lactylation exacerbates the…
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Artikel Jurnal
USP49 stabilizes MDMX and suppresses PPARα activity to mitigate isoproterenol-induced heart failure in preclinical models
Background: Ubiquitin-specific peptidase 49 (USP49) has been implicated in cardioprotection, yet its role in heart failure (HF) and the associated mechanism are poorly understood. This study deciphered the function of USP49 in HF and its interaction with MDM4 regulator of p53 (MDMX) and peroxisome…