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Future Journal of Pharmaceutical Sciences
ISSN 2314-7253 · SpringerOpen · 995 artikel di indeks
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Artikel Jurnal
A marvelous hope in the treatment of breast cancer: Moorena producens as an incredible source of bioactive metabolites with a variety of unique selective molecular mechanisms
Abstract Breast cancer is the most prevalent cause of cancer-related deaths among women worldwide. Patients that get chemotherapy endure severe side effects and develop drug resistance. To optimize the immune system's ability to destroy breast cancer, several strategies have been developed. Natural…
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Artikel Jurnal
Punicalagin and captopril mitigate the fibrogenic CD68+ macrophages through TGF-β1 and PPAR-γ signaling pathways in non-ischemic reactive myocardial fibrosis: a bioinformatic and in vivo experiment
Abstract Background Non-ischemic reactive myocardial fibrosis (MF) is a significant global cause of chronic heart failure (CHF) related to fatalities and morbidity. Punicalagin (PUN), a primary phenolic component in pomegranate, has been acknowledged as cardioprotective agent in isoproterenol…
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Artikel Jurnal
Protective effects of modafinil against α-naphthylisothiocyanate-induced cholestatic liver injury in mice: insights into inflammation and apoptosis modulation
Abstract This study examined the protective effects of the central nervous system stimulant modafinil (MODA) in a mouse model of cholestatic hepatitis caused by α-naphthylisothiocyanate (ANT). Cholestatic hepatitis is a liver disease that is characterized by liver damage, discomfort, and jaundice…
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Artikel Jurnal
Unveiling the anti-gout potential of terpenes isolated from Penicillium sp. supported by in silico studies
Abstract Background Genus Penicillium represents one of the most prolific fungi in terms of biosynthesis of bioactive secondary metabolites. This review aims to survey the reported terpenoids isolated from different species of genus Penicillium and virtually screen their potential as xanthine…
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Artikel Jurnal
Phytochemical diversity and antioxidant potential of four Egyptian Allium species
Abstract Background Allium genus encompasses widely consumed vegetables including onion, Welsh onion, garlic, and leek which are known for their rich bioactive compound content. Methods In the present study, the total phenolic and flavonoid contents, vitamin composition, in addition antioxidant…
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Artikel Jurnal
Pracaxi oil (Pentaclethra macroloba)-loaded nanofibers: a promising biomaterial for wound healing
Abstract Background Chronic and complex wounds remain a significant clinical challenge, requiring biomaterials that can provide structural support and bioactive signaling. Pentaclethra macroloba (Pracaxi) oil is recognized for its regenerative properties; its integration into advanced delivery…
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Artikel Jurnal
A comprehensive review on ethnobotany, phytochemistry, traditional and modern uses of chasteberry (Vitex agnus-castus L.)
Abstract Vitex agnus-castus L. (chaste tree) has a rich history of use in traditional medicine across various cultures for over 2500 years, particularly for gynecological issues. Its applications range from regulating menstrual cycles to alleviating premenstrual syndrome and menopausal symptoms…
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Artikel Jurnal
Comparison of methods for detecting ciprofloxacin in pharmaceuticals and urine: UV–Vis spectrophotometry versus poly ([Mn(Chr)3]Cl2)/PGE voltammetry
Abstract Background Ciprofloxacin (Cpro) is a drug belonging to the fluoroquinolones class which can contribute to bacterial resistance due to its improper and overuse, and excretion in urine as unchanged. Therefore, continuous monitoring is required. In this work, voltammetric technique with…
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Artikel Jurnal
Real-time sensing approaches and antibiofilm strategies for biofilm-associated infections: advances and perspectives on medical devices and clinical contexts
Abstract Background Biofilms are communities of microorganisms encased in a self-produced extracellular matrix. They can form on living hosts or in the environment, and a diverse range of microbes participate in this process. These include harmful bacteria that can become reservoirs for chronic…
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Artikel Jurnal
Exploratory metaproteomic profiling of the nasal microbiota in a pilot cohort of mothers and infants
Abstract Background The nasal passages’ microbial communities are vital to human health and can influence infection processes. In this study, ten nasal samples were obtained, five from mothers and five from their 1- to 2-year-old infants. We studied the proteins of the nasal passage microbiota…
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Artikel Jurnal
Biological modulation and repair using plant-derived bioactives: advancements in tissue engineering and regenerative medicine
Abstract Background The discipline of tissue engineering (TE) is experiencing significant advancements, characterized by both rapid progress and periods of slower development that sometimes fall short of earlier expectations. This review serves as a comprehensive inventory of achievements aimed at…
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Artikel Jurnal
Biochemical disturbances caused by ranitidine in rats: attention to bilirubin–lipids relation and benefits of capsiate
Abstract Ranitidine is an H2-receptor antagonist used to control acid disorders in the gastrointestinal tract. But the long-term use of ranitidine is related to liver dysfunction, which may alter bilirubin levels and disrupt lipid metabolism. Bilirubin, beyond being a liver function marker, plays a…
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Artikel Jurnal
The persistence of COVID-19 vaccine artifacts in bodily fluids and tissues: a systematic review
Abstract Background Early assumptions about COVID-19 vaccine components suggested that modified messenger RNA and spike protein would be rapidly cleared from the body, consistent with the known degradation pathways of natural RNA. However, multiple studies have identified these vaccine-derived…
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Artikel Jurnal
Belotecan in ovarian cancer anti-inflammatory potential and mechanistic insight to nano-formulations
Abstract Background Ovarian cancer is a major gynecologic malignancy with high morbidity and mortality rates. Current treatment options have limited long-term effectiveness due to tumor resistance and significant side effects. Main body This article explores the potential of belotecan, a derivative…
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Artikel Jurnal
Therapeutic potential of rutamarin: preclinical evidence of its biological properties through in silico, in vitro, and in vivo studies
Abstract Background In traditional medicine, natural compounds, such as coumarins, have been recognised as effective therapeutic agents for a variety of ailments. One of the natural furanocoumarins is rutamarin, which can be abundantly found in the Rutaceae family. It has been demonstrated to…
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Artikel Jurnal
Investigating the clinical outcomes of prolonged versus intermittent infusion of meropenem in critically ill pediatric patients: a randomized double-blind single-center study
Abstract Background Optimal antibiotic dosing strategies, such as prolonged infusion (PI), are hypothesized to improve clinical outcomes in critically ill patients by maximizing time above the minimum inhibitory concentration. This prospective study aimed to evaluate whether PI of meropenem…
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Artikel Jurnal
Repurposing baricitinib and/or rosuvastatin to reinvigorate the anticancer immune response via suppressing PD-1/PD-L1 and CTLA-4 inhibitory immune checkpoints and correlated oncogenic pathways in lung cancer models
Abstract Background Lung cancer is the prime cause of cancer-related death worldwide. It is an aggressive malignant tumor characterized by significant dysregulation of various oncogenic and immunosurveillance pathways. STAT3 is considered to be a point of convergence of such pathways, so it is an…
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Artikel Jurnal
Pharmaceutical nanotechnology research in Egypt: prospects in treatment of liver diseases, patenting, and regulatory implications
Abstract Background The application of nanotechnology in the biomedical field has greatly expanded in the last decade, as delineated by the large number of publications by several researchers. Particularly for liver diseases which are prevalent in Egypt, published research has delineated that…
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Artikel Jurnal
Rational design of a dual-function, LL-37/HNP-1, chimeric antimicrobial peptide: a broad-spectrum AMP against respiratory co-infections
Abstract Background Respiratory viral–bacterial co-infections remain difficult to treat because current therapies typically target pathogens individually. In this study, we designed and computationally evaluated a dual-function chimeric antimicrobial peptide that integrates the conserved antiviral…