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Einstein (São Paulo)
Scopus
ISSN 2317-6385 · Instituto Israelita de Ensino e Pesquisa Albert Einstein · 2.650 artikel di indeks
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Guided and unguided neural organoids play complementary roles in studying neurodevelopment and neuroinflammation
ABSTRACT Objective: This study aimed to compare guided dorsal forebrain neural organoids with unguided neural organoids, focusing on differences in structural organization, cellular composition, and functional properties. Methods: Using the same human induced pluripotent stem cell line, we applied…
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Difficulties in diagnosing a pediatric patient with small intestinal bacterial overgrowth
ABSTRACT A 3.5-year-old female presented with a 10-month history of abdominal pain and distension, accompanied by frequent belching and flatulence. No nausea, vomiting, or nighttime awakening due to pain was reported, and the patient's appetite remained intact. Growth and development were…
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Anesthetic practices and physiological foundations in fetal surgery: a literature review
ABSTRACT Fetal anesthesia plays a critical role in ensuring maternal and fetal safety and optimizing outcomes during fetal surgical interventions. Despite its importance, there is currently no consensus regarding optimal anesthetic strategies for these procedures. This narrative review explores the…
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Comment on: Transrectal prostate biopsy complications: a prospective single center study in a mid-income country
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Pulmonary artery aneurysm and tuberous sclerosis: case report
ABSTRACT Tuberous sclerosis is a rare and serious genetic disease, classically characterized by epilepsy, mental deficiency, and sebaceous adenomas; however, it may also be associated with the development of multiple tumors in various organs. Pulmonary artery aneurysm has rarely been described in…
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Performance of the Artificial Intelligence large language models ChatGPT 3.5, Gemini (Google Bard), ChatGPT 4.0, and Gemini 2.5 flash in surgical subspecialty questions of Brazilian medical residency exams
ABSTRACT Objective: Given the rapid advancement of Artificial Intelligence and its significant impact on medical education, particularly with the development of large language models, such as ChatGPT and Gemini, ChatBots have shown an increasing ability to support clinical reasoning. Regarding…
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SARS-CoV-2 infection and profound hearing loss: much more than a coincidence
ABSTRACT Objective: To describe a series of cases in which severe acute respiratory (SARS-CoV-2) infection was associated with profound sensorineural hearing loss. Our data provides extensive evidence that COVID-19 infections can cause sensorineural hearing losses. Methods: This study included…
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Combined tenofovir, lamivudine, and dolutegravir treatment increases leptin and FABP4 expression in human subcutaneous adipose tissue
ABSTRACT Introduction: Several antiretroviral regimens reportedly affect adipose tissue function. While earlier antiretroviral combinations were associated with lipodystrophy, more recent regimens, particularly those containing dolutegravir, have been linked to fat gain. However, the direct impact…
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Laser therapy: palliative care for the Harlequin syndrome?
ABSTRACT Harlequin syndrome is a rare condition characterized by facial dysautonomia with anhidrosis, hemifacial blush, and other nonfacial manifestations without conventional treatment. This report presents a case study of the potential treatment of Harlequin syndrome using laser therapy. A…
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Mutational signatures in hematological malignancies
ABSTRACT The set of somatic mutations present in a human tumor is a record of one or more mutational processes, each of which leaves distinct "signature" of mutation types. Mutation types can be classified in various ways, the most straightforward being the base change induced by a single-base…
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Thyroid cartilage resection surgery for metastases of clear cell renal cell carcinoma: case report and literature review
ABSTRACT Laryngeal cartilage is an exceptionally rare site of metastasis, with fewer than 63 cases reported in the literature; prostate, kidney, breast, and lung cancers are the most common primary tumors. In addition to this extreme rarity, most published reports are limited to descriptions of the…
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Revisiting volemic assessment via telemedicine: connecting traditional clinical needs with modern technology
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A tertiary care study on the effectiveness of moderate weight loss on heart rate variability frequency-domain components in obese patients at high cardiovascular risk
Abstract Objective: Cardiovascular diseases remain the leading cause of mortality, and obesity is a significant risk factor. This study aimed to investigate the impact of a structured nutritional intervention on weight loss, heart rate variability, and biochemical profiles in obese patients with…
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Disseminated juvenile paracoccidioidomycosis: a case report and literature review
Abstract We report a case of juvenile paracoccidioidomycosis in a previously healthy patient and aim to raise awareness of its severe and atypical clinical manifestations. A 16-year-old male student, employed in automotive cleaning services, originally from Pará and residing in Embu das Artes, São…
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Effect of respiratory muscle training on functional capacity related to the quality of life of patients undergoing coronary artery bypass grafting with cardiopulmonary bypass: randomized clinical trial
Abstract Objective: To evaluate the effects of inspiratory muscle training using POWERbreathe® in patients undergoing myocardial revascularization with extracorporeal circulation, focusing on respiratory and peripheral muscle strength, exercise capacity, functional independence, and quality of…
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