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Biomedical Journal
Scopus
ISSN 2319-4170 · Elsevier · 968 articles in the index
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Journal Article
Role of PAI-1 in the progression and treatment resistance of non-small cell lung cancer
Background: Lung cancer is the leading cause of cancer-related mortality worldwide. Although immune checkpoint inhibitors (ICIs), chemotherapy, and molecular targeted therapies have improved survival rates, therapeutic resistance remains a major barrier to curative outcomes. Recently, plasminogen…
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Journal Article
From inhibition to regulation: serpins in health and disease
This issue of the Biomedical Journal highlights regulatory mechanisms that shape aging, disease progression, and biological complexity across molecular, cellular, and systems levels. A central theme is plasminogen activator inhibitor-1 (PAI-1) as a multifunctional regulator linking fibrinolysis…
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Journal Article
The legacy and future of recurrent neural networks in personalized medicine: A reflection on the 2024 Nobel Physics Prize
The 2024 Nobel Physics Prize was awarded to Geoffrey Hinton and John Hopfield for their pioneering contributions to neural networks and artificial intelligence (AI), marking a significant milestone in AI’s development, particularly in the potential integrations into personalized medicine. This…
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Journal Article
Associations with lip cant and facial midline correction following bimaxillary surgery in class III asymmetry: A CBCT-based analysis
Background: This study evaluated the outcomes of bimaxillary surgery for class III asymmetry and lip cant, and identified factors associated with lip cant and facial midline correction. Materials and methods: Fifty adult patients (22 females, 28 males; mean age: 24.8 ± 5.1 years) with class III…
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Journal Article
PAI-1 is a common driver of aging and diverse diseases
Plasminogen activator inhibitor-1 (PAI-1) is a key driver of aging and contributes to diverse pathologies. This review examines PAI-1's multifaceted contributions to aging. At the cellular level, PAI-1 amplifies senescence, exhausts stem cell niches, and disrupts metabolism. These cellular…
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Journal Article
ShinySC: An R/Shiny-based desktop application for seamless analysis of scRNA-Seq data
Background: Single-cell RNA sequencing (scRNA-seq) enables detailed profiling of cellular heterogeneity, but complex workflows and diverse data formats limit accessibility for clinicians and researchers without programming expertise. Results: We introduce ShinySC, an R/Shiny-based desktop…
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Journal Article
Plasminogen activator Inhibitor-1 in systemic sclerosis: A nexus of fibrosis, vasculopathy, and senescence
Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic system, has emerged as a multifaceted contributor to the pathogenesis of systemic sclerosis (SSc). Beyond its classical role in inhibiting plasminogen activation, PAI-1 is implicated in the dysregulation of vascular…
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Journal Article
Dynamic regulation of RNA m6A methylation in the ribonucleoprotein complexes in apicomplexan and kinetoplastid parasites
m6A, or N6-methyladenosine, is the most abundant modification of mRNA transcripts. These modifications are known to influence mRNA transcript stability, transcription, translation, alternative splicing and decay, with undoubtedly more functions to be discovered. In this review, we explored the…
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Journal Article
Influence of acupuncture twisting parameters on analgesic effects mediated by mast cells in AA rat models
Acupuncture has been recognized for its potential effectiveness in pain relief without the side effects commonly associated with pharmaceutical treatments. This study investigates the effects of various acupuncture twisting parameters on analgesia using an acute adjuvant-induced arthritis (AA) rat…
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Journal Article
Overview: PAI-1 inhibitors and clinical applications
Plasminogen activator inhibitor-1 (PAI-1) is a protein involved in the fibrinolytic system and has been reported to be involved in various pathologies such as fibrosis and inflammation. We have developed small molecule inhibitors of human PAI-1 for clinical applications. A clinical candidate…
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Journal Article
Autophagy-induced osteoblast-derived exosomes maintain bone formation and prevent osteoporosis by remodeling gut microbiota-metabolism
Background: Osteoporosis is a chronic disease of bone metabolism with high incidence rates. Recently, exosome therapy has emerged as a promising avenue for the treatment of osteoporosis. However, the role of autophagy-induced osteoblast-derived exosomes (Auto-exo) in osteoporosis has yet to be…
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Journal Article
SLC7A11-HSPB1 axis: A novel mechanism for hepatocellular carcinoma progression and ferroptosis regulation
Background: SLC7A11, a plasma membrane protein, has been implicated as an oncogene in various cancers, including hepatocellular carcinoma (HCC). Its role in HCC pathogenesis, particularly in relation to ferroptosis, is not well understood. This study aims to investigate the function of SLC7A11 with…
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Journal Article
BrainView: A cloud-based deep learning system for brain image segmentation, tumor detection and visualization
A brain tumor is an abnormal growth in the brain that disrupts its functionality and poses a significant threat to human life by damaging neurons. Early detection and classification of brain tumors are crucial to prevent complications and maintain good health. Recent advancements in deep learning…
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Journal Article
PAI-1, hematopoietic stem cell, and chronic myeloid leukemia
The new treatment goal for chronic myeloid leukemia (CML) is treatment-free remission, which requires the achievement and maintenance of a deep molecular response (DMR) using a tyrosine kinase inhibitor (TKI). However, only a limited number of patients achieve or maintain DMR. TM5614, a PAI1…
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Journal Article
Defining epitranscriptomic hallmarks at the host-parasite interface and their roles in virulence and disease progression in Theileria annulata-infected leukocytes
Theileria parasites are known to induce the transformation of host bovine leukocytes, involved in rapid proliferation, evasion from apoptotic mechanisms, and increased dissemination. In this study, we reveal the involvement of m6A RNA modification in T. annulata infection-induced transformation of…
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Journal Article
Significance of PAI-1 on the development of skin cancer: Optimal targets for cancer therapies
Plasminogen activator inhibitor-1 (PAI-1) is a serine protease inhibitor that plays a critical role in cancer progression, particularly in skin cancers. PAI-1 is widely recognized for its role in inhibiting fibrinolysis; however, emerging evidence suggests that it also contributes to tumor…
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Journal Article
Ultrasound-guided intervention in adhesive capsulitis: A comprehensive review of therapeutic strategies
Adhesive capsulitis is a painful and disabling shoulder condition characterized by progressive synovial inflammation, capsular fibrosis, and global restriction of motion. Conventional treatment strategies, including physical therapy and landmark-guided intra-articular corticosteroid injection…
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Journal Article
Problematic ChatGPT use: Manifestations, etiologies, and evaluation
Background: ChatGPT has rapidly permeated various domains, including education, industry, creativity, and daily life. While offering efficiency and emotional engagement, excessive reliance may lead to problematic use with adverse effects on mental health, cognition, and social functioning. This…