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Journal of HerbMed Pharmacology
Scopus
ISSN 2345-5004 · Shahrekord University of Medical Sciences · 638 artikel di indeks
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Artikel Jurnal Teks lengkap
Antiepileptic potential of the aqueous extract of Crassocephalum bauchiense (Hutch.) Milne-Redh. (Asteraceae) in a kainate induced mouse model of temporal lobe epilepsy
Introduction: Temporal lobe epilepsy (TLE) is characterized by an imbalance between excitatory and inhibitory systems associated with neuroinflammation. These mechanisms contribute to therapeutic resistance and disease progression. Crassocephalum bauchiense (Hutch.) Milne-Redh. (Asteraceae) has…
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Propolis versus chlorhexidine mouthwash following impacted mandibular third molar surgery: A randomized clinical trial
Introduction: Propolis has anti-inflammatory, antimicrobial, and wound-healing properties. This study compared the effects of propolis and chlorhexidine mouthwash on the gingival index (GI), plaque index (PI), and incidence of dry socket (DS) after surgical extraction of impacted lower third…
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Dose-dependent antidiabetic, antihyperlipidemic, and hepatoprotective effects of Piper betle leaf powder suspension in streptozotocin-induced diabetic mice
Introduction: Piper betle (PB) is rich in bioactive compounds and traditionally used for its antihyperglycemic and hepatoprotective properties. This study examined the dose-dependent hypoglycemic, hypolipidemic, and hepatoprotective responses to a suspension of PB leaf powder in streptozotocin…
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Phytochemical screening, antioxidant potential, and nutritional analysis of five Polyscias species: An in vitro and in vivo study
Introduction: Species of the genus Polyscias (Araliaceae) have long been used in traditional medicine because of their anti-inflammatory, antibacterial, and antioxidant properties. However, information on the phytochemical composition, antioxidant activity, and nutritional value of several…
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Methanolic extract of Karo-derived Trigonella foenum-graecum induces apoptosis and cell-cycle arrest in breast cancer cells through modulation of PI3K/AKT/mTOR signaling
Introduction: Breast cancer therapy often faces challenges with drug resistance and severe side effects, highlighting the urgent need for novel therapeutic agents. Trigonella foenum-graecum (TFG) contains steroid sapogenins with potential as anti-cancer agents. This study assessed the methanolic…
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Anti-ferroptotic lignan glycosides from Zanthoxylum avicennae: Isolation, structural characterization, and mechanistic evaluation
Introduction: Ferroptosis, a regulated cell death driven by iron-dependent lipid peroxidation, has been implicated in various liver diseases. Small molecules that counteract ferroptosis remain largely restricted to a few synthetic scaffolds, leaving natural products an underexplored source…
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A systematic review of fisetin in oral premalignant and malignant disorders: Molecular mechanisms and therapeutic potential
Introduction: Oral cavity neoplasms pose a public health concern worldwide. We aimed to systematically review the current molecular mechanisms and preclinical efficacy of fisetin (FIS) in oral premalignant and malignant disorders. Methods: A systematic review was conducted following the PRISMA…
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In vitro and in vivo studies of medicinal plants against hepatitis B and hepatitis C infections: A narrative review
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remain major global health problems. This review summarizes current evidence on medicinal plants with reported antiviral activity against HBV and HCV, focusing on experimental models and underlying molecular mechanisms. A narrative…
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Anti-acid and anti-secretory activities of the aqueous extract of Microdesmis keayana J. Léonard (Pandaceae) leaves on gastric hypersecretion induced in Wistar rats
Introduction: Gastric acid hypersecretion is a major contributing factor to peptic ulcer disease. This study aimed to evaluate the anti-secretory and anti-acid activities of the aqueous leaf extract of Microdesmis keayana (AEMk) in experimental models of gastric hypersecretion in Wistar rats, based…
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Therapeutic potential of [6]-gingerol in musculoskeletal diseases through modulation of inflammation and oxidative stress: A mini-review
Musculoskeletal diseases (MSDs), including osteoarthritis, rheumatoid arthritis, and osteoporosis, represent major contributors to chronic pain, functional impairment, and disability worldwide. Chronic inflammatory activity and disrupted redox balance are increasingly recognized as important…
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Determination of the correlative association between phytochemical content and nitrite inhibition in selected medicinal plants used traditionally to treat respiratory infections
Introduction: Several medicinal plants, including Artemisia afra Jacq. Ex Willd, Lippia javanica (Burm.f.) Spreng, Tetradenia riparia (Hochst.) Codd, and Tulbaghia violacea Harv have been used in treating illnesses such as respiratory infections and their associated inflammatory dysregulation. The…
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Phytochemical profiling and bioactivity assessment of crude methanolic extracts from different parts of Merremia emarginata: Antibacterial, antioxidant, thrombolytic, and cytotoxic evaluations
Introduction: Merremia emarginata, a member of the Convolvulaceae family, is used to combat various maladies associated with infection, oxidative stress, and inflammation. Methanolic extracts prepared from the leaves, roots, and stalks of M. emarginata were evaluated for their phytochemical…
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Acacia tortilis ssp. raddiana: Analgesic and anti-inflammatory activities and early therapeutic effects in pulmonary fibrosis
Introduction: Acacia tortilis ssp. raddiana is rich in bioactive phytochemicals, particularly phenolic constituents, exhibiting antioxidant and anti-inflammatory activities. Therefore, this study investigated the phytochemical composition and analgesic, anti-inflammatory, and anti-fibrotic effects…
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The role of eugenol in modulating PRKAA1 expression and cellular energy homeostasis in breast cancer
Introduction: Eugenol, a natural phenolic compound obtained from clove and cinnamon, has been reported to show anticancer properties in breast cancer models. Metabolic reprogramming is a hallmark of breast cancer and can be regulated by AMPK. The PRKAA1 gene encodes the catalytic subunit of AMPKα1…
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Double-edged role of antioxidants and oxidative stress: Focusing on cancer therapy and resistance
Oxidative stress and antioxidant systems are complex components of human physiology and pathology. Reactive oxygen species (ROS), previously viewed as undesirable byproducts of cellular metabolism, have now been identified as critical signaling agents that participate in cell proliferation…
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Bioactive components, mechanisms, and applications of functional seeds (Flaxseed, chia, pumpkin, hemp, and sesame) in insulin resistance: A mini-review
Insulin resistance is a significant metabolic dysfunction that contributes to the pathogenesis of type 2 diabetes mellitus (T2DM). As interest grows in functional foods for chronic disease management, seeds of various plants, such as Linum usitatissimum (flaxseed), Salvia hispanica (chia)…
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Dual antidiabetic and anticancer potential of Melia dubia seed extract: An integrated in silico and in vitro study
Introduction: Melia dubia seeds are traditionally used against diabetes mellitus and cancer. Molecular docking studies were performed to evaluate the binding affinity of major compounds against α-glucosidase and the mechanistic target of rapamycin (mTOR), a key regulator of cell growth and…
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Unravelling potential molecular targets of quercetin antibacterial activity against Staphylococcus aureus-infected wound through gene network, in silico, and in vitro approaches
Introduction: Staphylococcus aureus is a pathogenic bacterium commonly present in chronic wounds and can contribute to clinical complications, particularly among diabetic patients. Quercetin is a natural flavonoid with outstanding antioxidant and antibacterial properties. This study aimed to…
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n-Butanol fraction from Hedysarum alpinum L. attenuates scopolamine-induced memory impairment in rats
Introduction: Hedysarum alpinum L. (HA) contains considerable amounts of polyphenols and saponins, and exhibits immune-enhancing and antiviral properties. Evidence indicates that triterpenoid saponins possess neuroprotective effects against neurodegenerative damage. The present study evaluated the…
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In vitro antiviral activity of thymoquinone and its synergistic effect with acyclovir against herpes simplex virus type 1 (HSV-1)
Introduction: Drug resistance has heightened the demand for natural antiviral agents. Thymoquinone (TQ), a major bioactive component of black seed oil, has demonstrated antiviral activity in numerous studies. However, its potential efficacy against herpes simplex virus type 1 (HSV-1) has not been…