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Journal of Medical Microbiology and Infectious Diseases
ISSN 2345-5349 · Pasteur Institute of Iran · 318 artikel di indeks
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Artikel Jurnal
Suspected Crimean-Congo Haemorrhagic Fever Re-Infection: A Case Report with Atypical Serological Profile
A 53-year-old male farmer presented with clinical manifestations consistent with Crimean-Congo Hemorrhagic Fever (CCHF) virus infection, reporting a recent history of tick bite. To confirm the diagnosis, molecular and serological assays were performed on four specimens collected following the onset…
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Antimicrobial Susceptibility Trends in Uropathogens: A 6-Year Retrospective Study from Kerala, India
Introduction: Antimicrobial resistance (AMR) among uropathogens is a critical global public health challenge, potentially exacerbated by the COVID-19 pandemic. This study evaluates the pandemic’s impact on antimicrobial susceptibility trends among uropathogens at a tertiary care center in Kerala…
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Artikel Jurnal
Antibacterial and Antibiofilm Efficacy of a Synthetic Nitrofuranyl Pyranopyrimidinone Derivative against Methicillin-Resistant Staphylococcus aureus
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a major public health concern due to its multidrug resistance and robust biofilm formation, which contribute to persistent infections and treatment failures. Novel antibiofilm agents are urgently needed to combat drug resistant…
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Artikel Jurnal
Burkholderia gladioli Septicemia: A Rare Case Report
Introduction: Burkholderia gladioli is an emerging opportunistic pathogen in humans. Its phenotypic variability makes identification challenging and can lead to misidentification with closely related Burkholderia species. Case presentation: We report a case of B. gladioli septicemia in a patient…
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Artikel Jurnal
Trends in the Microbial Profile of Bronchoalveolar Lavage Samples from Patients with Lower Respiratory Tract Infections
Introduction: Lower respiratory tract infections (LRTIs) contribute substantially to global morbidity and mortality, with bacterial and fungal causative agents exhibiting regional and temporal variations. Evolving antimicrobial resistance patterns among bacterial pathogens pose challenges to…
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Artikel Jurnal
Remdesivir Modulates CASP8 and CASP9 Expression in COVID-19 Patients: Impact on Apoptotic Pathways and Immune Response
Introduction: COVID-19, caused by SARS-CoV-2, is associated with alterations in apoptotic signaling pathways, which influence disease progression and immune function. CASP8 and CASP9 are key regulators of apoptosis. This study aimed to evaluate the expression levels of the CASP8 and CASP9 genes in…
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Clinical Characteristics, Breakthrough Infections, and Reinfections with SARS CoV-2 among Healthcare Workers in the Omicron Wave
Introduction: A global increase in infections was noted with the emergence of the Omicron variant, which exhibited immune evasion capabilities against previous infections or vaccinations. Healthcare workers (HCWs) faced increased risk from occupational exposure. This study aimed to investigate the…
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Artikel Jurnal
Molecular Detection and Antibiotic Susceptibility Pattern of Shiga Toxin Producing Escherichia coli among Children with Diarrhea in Addis Ababa, Gondar, and Harar, Ethiopia
Introduction: Shiga toxin-producing Escherichia coli (STEC) is a major cause of pediatric diarrhea globally, yet its burden, molecular characteristics, and antibiotic resistance patterns remain underexplored in low-resource settings like Ethiopia. This study aimed to assess the molecular detection…
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Artikel Jurnal
Nanoplatform-Based Delivery Systems for Enhanced Stability and Efficacy of Nucleic Acid Vaccines
The rapid development of nucleic acid-based vaccines represents a major advancement in immunization strategies, characterized by their reliance on host cellular machinery to produce antigens. These third-generation platforms, including DNA and mRNA vaccines, offer key advantages such as rapid…
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Artikel Jurnal
A Review and Comparative Study of Preservative Efficacy Test in the United States, European, Indian, and Japanese Pharmacopeias and Implications for Asian Pharmacopeias
Introduction: The preservative efficacy test (PET) is a critical tool for assessing the ability of antimicrobial preservatives to prevent microbial contamination in pharmaceutical products, ensuring their safety and stability during production and storage. This study reviews and compares PET…
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Assessment of Knowledge Attitude and Practices of Rural Population Towards Infectious Diseases and Their Prevention
Introduction: Understanding the etiological agents, reservoirs, and transmission dynamics of infectious diseases is crucial for developing effective prevention and control strategies, particularly in rural settings where healthcare access and awareness may be limited. Past pandemics, such as…
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Lactococcus lactis as a Live-Vector Vaccine Platform for Parasitic Diseases
The development of expression systems using non-pathogenic microorganisms has enabled efficient and safe platforms for medical and food applications, including functional foods with therapeutic benefits. Among non-pathogenic bacteria, Lactococcus lactis (L. lactis) is widely used in biotechnology…
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Artikel Jurnal
Surveillance of Respiratory Syncytial Virus, Influenza A and B viruses in COVID-19 Negative Individuals in Oyo State, Nigeria
Introduction: The COVID-19 pandemic highlighted the need for robust surveillance of other respiratory viruses, as their overlapping clinical presentations with SARS-CoV-2 can complicate accurate diagnosis. This retrospective study investigated the prevalence of Respiratory Syncytial Virus (RSV) and…
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Artikel Jurnal
Status of Metallo-β-Lactamase-Producing Organisms in Clinical Samples
Introduction: Carbapenem resistance, due to the production of carbapenemase enzymes in various bacteria, is responsible for numerous outbreaks and is significantly associated with healthcare-associated infections. Metallo-β-lactamases (MBLs) are carbapenemases that hydrolyze all β-lactam…
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Artikel Jurnal
Malaria Prevalence and Associated Risk Factors in Al Managil city, Aljazeera state, Sudan
Introduction: Malaria remains a significant public health challenge in Aljazeera State, Sudan, substantially contributing to morbidity, particularly in areas like Al Managil City. This study aimed to determine malaria prevalence and associated risk factors in Al Managil City to inform targeted…
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Artikel Jurnal
Evaluating the Efficacy of Training and Education on Lowering Blood Culture Contamination Rates in a Tertiary Care Hospital
Introduction: Blood culture remains the gold standard for diagnosing bloodstream infections. Contamination during the collection, transport, or processing of blood culture samples can obscure the true pathogens with contaminant growth, thereby complicating or delaying the diagnosis of bacteremia…
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Artikel Jurnal
Sporadic Stenotrophomonas maltophilia Respiratory Infections in Cancer Patients
Introduction: Stenotrophomonas maltophilia is a bacterium that increasingly causes respiratory and bloodstream infections, particularly in individuals with compromised immune systems, such as cancer patients. This study investigates a series of S. maltophilia respiratory infections among cancer…
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Artikel Jurnal
Cyclomodulins, Colibactin, and Biofilm-Associated Genes in E. coli from Colorectal Cancer and Precancerous Lesions
Introduction: Colorectal cancer (CRC) remains a significant global health challenge. Specific strains of Escherichia coli elaborating virulence factors, including cyclomodulins and colibactin, have been increasingly implicated in CRC pathogenesis. This study aimed to determine the prevalence of…
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Artikel Jurnal
Evaluating Rubella Immunity in Women of Reproductive Age in Mysuru: A Cross-Sectional Serosurvey
Introduction: This study aimed to determine the seroprevalence of rubella IgG antibodies among women of reproductive age in Mysuru, India. Estimating the rubella seroprevalence in this populationis crucial for informing public health interventions aimed at preventing congenital rubella syndrome…
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Artikel Jurnal
Differential Immunostimulatory Effects of EGFP and +36 GFP on Immune Cells
Introduction: Green fluorescent protein (GFP) and its variants are pivotal in tracking gene expression across various gene delivery systems. While GFP is typically employed for intracellular reporting, it can be modified to display on cell surfaces for labeling. Previous research indicates GFP…