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Journal of Applied Pharmaceutical Research
Scopus
ISSN 2348-0335 · Creative Pharma Assent · 498 artikel di indeks
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Artikel Jurnal
Vanillin as a cardioprotective agent against anthracycline-induced cardiotoxicity in Wistar rats via modulation of oxidative stress and molecular docking analysis
Background: Doxorubicin (DOX) is limited by dose-dependent cardiotoxicity mediated by reactive oxygen species (ROS) and oxidative stress. Natural phenolic compounds, such as vanillin, with antioxidant properties, are being explored as cardioprotective agents. This study evaluated vanillin using…
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Artikel Jurnal
Formulation and evaluation of piperacillin tazobactam loaded aquasomal gel for the treatment of noma
Background: Noma is a rapidly progressing gangrenous disease that affects the oral and facial tissues, mainly in malnourished and immunocompromised children. Delayed intervention often results in severe tissue destruction, facial deformity, and high morbidity. Although broad-spectrum antibiotics…
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Artikel Jurnal
Development and evaluation of a Cassia tora-based herbal antacid suspension
Background: Synthetic antacids are frequently used to manage gastric hyperacidity; however, their potential for long-term adverse effects has catalyzed significant interest in developing safer herbal-based therapeutic alternatives. Cassia tora, traditionally used for gastrointestinal disorders…
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Artikel Jurnal
Development and optimization of a mechlorethamine topical formulation utilizing a model drug bridging strategy and quality by design
Background: This study aimed to develop a stable, clinically suitable topical mechlorethamine formulation using Quality by Design (QbD) principles to address chemical instability and cytotoxicity. The objectives were to establish a data-driven formulation design space, identify critical material…
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Artikel Jurnal
AQbD enabled optimization of RP-HPLC method for the estimation of pioglitazone and vildagliptin and its forced degradation studies
Background: Diabetes mellitus is a metabolic disorder that is managed with combination therapy. Pioglitazone improves insulin sensitivity by activating PPAR-γ, whereas vildagliptin increases incretin activity by inhibiting DPP-4. Their fixed-dose combination requires reliable analytical methods for…
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Artikel Jurnal
Kaempferol-rich Thespesia lampas leaf extract mitigates gentamicin-induced nephrotoxicity via antioxidant and anti-inflammatory mechanisms in wistar rats
Background: Gentamicin-induced nephrotoxicity (GIN) is a major limitation of aminoglycoside therapy and a common cause of acute kidney injury (AKI). The underlying mechanisms involve excessive oxidative stress and activation of inflammatory signaling pathways, particularly the nuclear factor-κB…
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Artikel Jurnal
Quinoxaline amino derivatives as potential EGFR-targeted therapeutics in breast cancer: computational exploration
Background: Despite resistance to current tyrosine kinase inhibitors, which makes the epidermal growth factor receptor (EGFR) a recognized therapeutic target in breast cancer, there is a need for novel inhibitors. Quinoxaline compounds are a promising scaffold for next-generation EGFR inhibitors…
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Artikel Jurnal
Harnessing essential oils through nanotechnology-based drug delivery systems for biomedical applications: current trends and future prospects
Background: Essential oils (EOs) have been used in therapeutic applications for centuries and continue to be popular in modern complementary and alternative medicine. EOs are highly concentrated, plant-derived volatile components with a wide range of biological activities, including analgesic…
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Artikel Jurnal
Biochemical characterization, GC-MS metabolite profiling, and heavy metals assessment of Rokshi: safety assessment and nutritional potential of a traditional fermented rice beverage of Monpa tribe
Background: Rokshi is a traditional fermented rice beverage widely consumed by the Monpa tribe of Arunachal Pradesh, a Northeastern State in India, with cultural, nutritional, and biochemical significance. Methodology: Standard analytical methods were employed to determine pH, alcohol content…
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Artikel Jurnal
Formulation and characterization of spray-dried clarithromycin microparticles with improved dissolution and potential for oral bioavailability
Background: Clarithromycin, a macrolide antibiotic, exhibits limited aqueous solubility, which restricts its dissolution and bioavailability. Enhancing its solubility through novel formulation strategies is essential to improve therapeutic efficacy. Spray drying with hydrophilic carriers is an…
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Artikel Jurnal
Design, synthesis, and in silico evaluation of 1,4 dihydropyridine and 3,4 dihydropyrimidine 2(1H)-ones/thione derivatives
Background: Pyridine and pyrimidine derivatives occupy a central position in medicinal chemistry owing to their broad pharmacological significance. In particular, 1,4-dihydropyridines and 3,4-dihydropyrimidines are known for their anti-hypertensive and anti-anginal activities, encouraging further…
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Artikel Jurnal
Formulation and comparative evaluation of allopurinol transdermal patches using two different polymeric combinations
Background: The transdermal drug delivery system is a technique where drugs are absorbed via the skin at a predetermined and controlled rate. This system offers several benefits over conventional routes, such as intravenous or oral administration, for both systemic and local drug delivery, and it…
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Artikel Jurnal
An in silico network pharmacology and molecular dynamics simulations study of engeletin in ischemic stroke with computational prioritisation of NOS2
Background: Engeletin, a polyphenolic flavonoid, has demonstrated neuroprotective effects in experimental stroke models. However, the molecular interactome underlying its multitarget actions in ischemic stroke remains insufficiently characterized. Methodology: An integrated in silico workflow was…
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Artikel Jurnal
Novel phytosomal drug delivery systems in cancer therapy: advances, mechanisms, and translational potential
Background: Phytochemicals are medicinal plants with strong anticancer properties that alter various molecular pathways involved in tumor initiation, progression, and metastasis. Several adverse factors, however, hamper their clinical translation: low aqueous solubility, low membrane permeability…
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Artikel Jurnal
Comparative pharmacological and clinical review of selected herbal antihypertensive agents in hypertension management
Background: Hypertension is a major global health concern and a leading risk factor for cardiovascular morbidity and mortality. Limitations associated with conventional antihypertensive therapy, including poor compliance, adverse effects, and inadequate blood pressure control, have increased…
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Artikel Jurnal
AQbD assisted UPLC method development and validation of tirzepatide in bulk and pharmaceutical dosage form
Background: Tirzepatide is a USFDA-approved (2023) synthetic drug that primarily targets blood sugar metabolism for chronic weight management, obesity-related conditions, and type 2 diabetes. In this study, we aim to develop a reliable, sensitive UPLC method for estimating Tirzepatide using…
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Artikel Jurnal
Formulation and characterization of risperidone nanocrystals for enhanced solubility and dissolution
Background: Risperidone (RIS) is categorized as a BCS Class II antipsychotic and exhibits poor water solubility and a slow dissolution rate, which restricts its therapeutic effectiveness. The present study aims to formulate RIS nanocrystals to overcome pharmaceutical challenges and improve their…
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Artikel Jurnal
Acute toxicity evaluation and antidyslipidemic potential of Retama sphaerocarpa aerial parts in Triton WR-1339 induced hyperlipidemic rats
Background: Dyslipidemia constitutes a major risk factor for cardiovascular diseases. Although conventional lipid-lowering therapies are effective, their prolonged use is associated with adverse effects, highlighting the need for safer natural alternatives. Species of the genus Retama, including…
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Artikel Jurnal
Development, in-vitro and ex-vivo evaluation of HPMC E-15/Xanthan gum mucoadhesive buccal patch of telmisartan
Background: Telmisartan, an antihypertensive drug, exhibits poor aqueous solubility and low oral bioavailability due to extensive hepatic first-pass metabolism. Buccal delivery offers a potential alternative route to bypass first-pass metabolism and achieve sustained drug release for better blood…
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Artikel Jurnal
Analytical profiling and antioxidant characterization of flavonoids from himalayan black soybean (Glycine max)
Background: Black soybean is a leguminous crop of great phytochemical interest and importance in traditional systems due to its alleged health-promoting effects. To a great extent, these advantages are attributed to its flavonoid content, a class of polyphenols known for their strong antioxidant…