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Bone Reports
Scopus
ISSN 2352-1872 · Elsevier · 1.479 artikel di indeks
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Artikel Jurnal
Phosphodiesterase inhibitors as emerging therapeutics for skeletal disorders: A comprehensive review of mechanisms and repurposing potential
Skeletal disorders such as osteoporosis, osteoarthritis, and rheumatoid arthritis represent major global health burdens with limited therapeutic innovation. Inhibitors of phosphodiesterases (PDEs), enzymes that regulate the intracellular levels of the cyclic nucleotides cAMP and cGMP, are…
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Artikel Jurnal
Effects of high-dose methotrexate on bone metabolism: A narrative literature review
Methotrexate (MTX) play an important role in oncology, where it is used in high-dose therapy regimens. However, its associated dose-dependent toxicity, including MTX-osteopathy, poses a serious clinical problem, particularly in pediatric oncology. Even in patients with inflammatory rheumatic…
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Artikel Jurnal
Assessing cortical bone changes with Romosozumab after one year: Insights from an exploratory HR-pQCT study
Purpose: To describe changes in bone microarchitecture after 6 and 12 months of romosozumab (ROMO), identify responders based on cortical thickness (Ct.Th) increase at the distal radius (≥3% at 12 months), and explore factors associated with treatment response. Methods: We conducted a prospective…
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Artikel Jurnal
Osteogenesis Imperfecta with a gross deletion including the COL1A1 gene, induced by Alu-driven microhomology-mediated end joining
Osteogenesis Imperfecta (OI) is a rare hereditary brittle bone disorder typically caused by COL1A1 and COL1A2 variants impairing type I collagen. However, gross deletions involving COL1A1 are uncommon. Here, we report a family with type I OI harboring a 101-kbp deletion encompassing COL1A1…
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Artikel Jurnal
Effectiveness of romosozumab following prior raloxifene treatment in primary osteoporosis: An observational study
Romosozumab is an anti-sclerostin antibody that increases bone formation and decreases bone resorption. It has been available for patients at high risk of osteoporotic fractures in Japan since 2019. The aim of this study was to clarify the clinical effectiveness and safety of romosozumab following…
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Artikel Jurnal
Rapid fracture healing of the greater tuberosity fragment after shoulder hemiarthroplasty in a patient with daily abaloparatide injection: A case report
We report a case of a 64-year-old woman who developed a 4-parts shoulder fracture-dislocation with peripheral nerve injury by the displaced fragment, during abaloparatide treatment. Following shoulder hemiarthroplasty, bone union at the greater tuberosity was achieved on postoperative day 16, with…
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Artikel Jurnal
Development of a large porcine model of osteogenesis imperfecta type I
Osteogenesis imperfecta (OI) comprises a group of disorders that lead to bone fragility. The most common forms are caused by pathogenic variants in COL1A1 and COL1A2. There are many different animal models OI from zebrafish to dogs, with murine models being the most used model. In this brief study…
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Artikel Jurnal
Selective deletion of the membrane-bound isoform of CSF1 in vivo augments the anabolic response to PTH without impairing bone resorption
Single daily doses of parathyroid hormone (PTH) are an established anabolic therapy for osteoporosis. The actions of PTH in bone are modulated by interactions between osteoblasts and osteoclasts. Colony-stimulating factor 1 (CSF1) exists in both soluble (sCSF1) and membrane-bound (mCSF1) isoforms…
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Artikel Jurnal
The effect of spaceflight on tissues of the spinal column
The unique mechanical unloading induced by spaceflight is associated with a very high incidence rate of chronic back pain and general degradation of tissues associated with the spinal column (i.e., bone, skeletal muscle, intervertebral disc, and cartilage). Despite the well documented phenomena of…
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Artikel Jurnal
Intelligent identification of osteoporosis on hip X-rays using vision transformer
Objective: This study aimed to develop and evaluate a deep learning model based on the Vision Transformer (ViT) architecture for the automatic classification of hip X-ray images into three categories: normal bone mass, osteopenia, and osteoporosis. The goal was to explore the model's potential for…
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Artikel Jurnal
Post-translational modifications of collagen type I in osteogenesis imperfecta: Systematic review and meta-analysis
Osteogenesis imperfecta (OI) is a rare genetic disorder most often caused by mutations in genes that encode collagen type I. OI collagen-I differs from healthy collagen-I due to the underlying mutation and altered post-translational modifications (PTMs). The objective of this study was to use…
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Artikel Jurnal
Erythropoietin and bone health: Single high-dose administration triggers bone loss in mice
Erythropoietin (EPO) is a key regulator of erythropoiesis, and it is mainly used to treat anemia. However, it is also administered prophylactically to non-anemic patients in certain clinical settings and is known to be used illicitly by athletes. The effect of EPO is controversial but emerging…
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Artikel Jurnal
Interdisciplinarity of secondary osteons: relevance of bioarchaeological and palaeontological research in biomedical cortical bone histology studies
Secondary osteons are fundamental products of bone metabolic processes. They accumulate, crowd, and superimpose over themselves over the lifespan of the individual and capture significant biological, environmental, and even social information. They are crucial in biomedical research as a reflection…
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Artikel Jurnal
Successful management of denosumab discontinuation in a patient with primary pediatric osteoporosis
Treatment of a 13.5-year-old boy with severe primary osteoporosis and multiple vertebral deformities with denosumab (Dmab) 60 mg subcutaneously every 3 months for 30 months, resulted in significant clinical, radiologic and densitometric improvement. During the second year of treatment, 2 episodes…
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Artikel Jurnal
Pilot proteomics study of three different human femur sites and autologous serum samples
Tissue proteomics will help discover the molecular pathophysiology of bone diseases. So far, most human studies have been performed on serum/plasma samples. We present an initial pilot proteomics analysis comparing three clinically important anatomical femur sites (caput, collum, and trochanter)…
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Artikel Jurnal
Burosumab improves alkaline phosphatase and rickets severity in X-linked hypophosphatemia: 3-year SUNFLOWER analysis
SUNFLOWER is a 10-year longitudinal observational cohort study of patients with X-linked hypophosphatemia (XLH) in Japan and South Korea. This report describes the 3-year cut-off of SUNFLOWER, including data from 1 year of burosumab administration (burosumab-treated group) and 1 year after…
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Artikel Jurnal
A novel PTH1R missense variant in a patient with early-onset primary hyperparathyroidism
We report a 30-year-old male with early-onset primary hyperparathyroidism (PHPT) and incidental papillary thyroid carcinoma. Biochemical tests showed hypercalcemia, hypophosphatemia, elevated PTH and normal renal function. Planar 99ᵐTc-MIBI scintigraphy projected a parathyroid lesion to the left…
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Artikel Jurnal
Unidirectional porous beta-tricalcium phosphate supports three-dimensional osteogenic differentiation of human iPS cells without surface coating
Beta-tricalcium phosphate (βTCP) is widely used as a bone graft substitute, but it lacks intrinsic osteogenic cells. Human induced pluripotent stem cells (iPSCs) are a promising cell source for bone regeneration; however, the suitability of clinically available, uncoated βTCP as a scaffold for iPSC…
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Artikel Jurnal
Orthopaedic diagnostic pitfalls in fibroblast growth factor 23-mediated hypophosphatemic rickets/osteomalacia in fibrous dysplasia/McCune-Albright syndrome: Two burosumab-treated cases
Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) can obscure fibroblast growth factor 23 (FGF23)-mediated hypophosphatemic rickets/osteomalacia. We report two FD/MAS patients with recurrent fractures, hypophosphatemia, elevated FGF23, and serial imaging showing overlooked rachitic changes years…
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Artikel Jurnal
Children with unilateral spastic cerebral palsy have smaller and weaker tibias in the spastic limb compared to the non-spastic limb
Cerebral palsy (CP) is associated with poor bone architecture. It is unclear if abnormal bone architecture is localized to the area affected by spasticity and whether these deficiencies are dependent on physical activity. This study aimed to examine differences in tibial bone architecture between…
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