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Neurobiology of Stress
Scopus
ISSN 2352-2895 · Elsevier · 789 articles in the index
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Journal Article
Hydroxytyrosol confers resilience against the depressive, anxiogenic and cognition-disruptive effects of chronic stress
Our understanding of the causal mechanisms of disorders such as anxiety and depression remains rudimentary. There is a pressing need to develop disease-modifying and preventative therapies that can be administered early and reduce symptom emergence. Here, we used a novel chronic unpredictable…
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Journal Article
Infant-mother attachment security and cortisol reactivity during the strange situation procedure: Longitudinal associations with maternal depressive symptoms and infant temperament
This study examined the influence of infant-mother attachment security on the regulation of the hypothalamic-pituitary-adrenal (HPA) axis and cortisol stress responses in 14-month-old infants. Eighty-two mother-infant dyads participated in the Strange Situation Procedure (SSP), with salivary…
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Journal Article
Differential associations between early life adversity subtypes and adolescent stress reactivity across neuroendocrine, autonomic, immune, and metabolic systems
Early life adversity (ELA) is a heterogeneous construct that can include the consequences of poverty, maltreatment, or serious accidents. This study characterized associations between subtypes of ELA and the physiological responses of multiple systems to acute psychosocial stress. Studies to date…
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Journal Article
Sensitive windows, sensitive outcomes: Early or late-postnatal maternal separation differentially impacts puberty and behavior
Early-life adversity disrupts the maturation of neuroendocrine, cognitive, and emotional regulatory systems, yet outcomes likely depend on both the timing of development and sex. Maternal separation (MS) in rodents is a widely used model for studying these effects, yet the sex-specific consequences…
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Journal Article
The role of proinflammatory response and the kynurenine pathway in the association between childhood maltreatment and lifetime substance use disorder
Introduction: Childhood maltreatment (CM) is a risk factor for adult psychiatric and substance use disorders (SUD). Retrospectively assessed CM has been linked to increased proinflammatory cytokines, including IL-6. Induced by inflammation, the neurotoxic branch of the kynurenine pathway has been…
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Journal Article
From teratogens to trajectories: Integrating teratology and Developmental Origins of Health and Disease (DOHaD) frameworks for a new take on fetal alcohol spectrum disorders (FASD)
Research on the effects of prenatal alcohol exposure (PAE) developed within two research frameworks that progressed largely in parallel. Classical teratology was the dominant framework for many years, focusing on prenatal exposure to toxic agents that disrupted developmental processes, resulting in…
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Journal Article
Brain network centrality following stress in adults with major depressive disorder and childhood trauma
Background: Childhood trauma (CT) is a major risk factor for major depressive disorder (MDD), potentially via altered stress system development. Previous studies have shown stress-related changes in brain network function in clinical populations, but evidence in MDD with CT remains scarce. This…
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Journal Article
Alterations of microRNAs across human and mouse limbic brain areas: molecular mechanisms and biological processes involved in major depressive disorder
The etiology of major depressive disorder (MDD) is multifactorial with both genetic and environmental factors, such as adverse/stressful life events, contributing to risk. There is some evidence suggesting that microRNAs (miRNAs) mediate environmental-genetic interaction leading to the brain…
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Journal Article
Early adversity alters neurodevelopmental milestones in male and female rat pups and motor cortex morphology and gait in juveniles
Early life stress (ELS) and adversity influences neurodevelopmental trajectories and affects maturation of brain circuits, network connectivity and epigenetic regulation, leading to increased vulnerability to adult psychopathology. ELS timing targets sensitive periods for neural plasticity, which…
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Journal Article
Comparative analysis of multiple chronic unpredictable mild stress paradigms in mice: Behavioural and physiological validity
The chronic unpredictable mild stress (CUMS) paradigm is one of the most widely used preclinical models to investigate the role of stress in the neurobiology of depression and to evaluate potential antidepressant therapies, owing to its strong translational relevance. However, despite its extensive…
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Journal Article
Early life visceral stress induces auditory brainstem sensitization and cochlear proteomic alterations in a rat model of irritable bowel syndrome
Early life stress is increasingly recognized as a critical factor shaping neural development and long-term sensory processing. It is also a well-established driver of visceral dysfunction and central to the pathogenesis of irritable bowel syndrome (IBS). While gastrointestinal and psychological…
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Journal Article
Integrated brain and body mechanisms underlying acute stress and trauma-related vulnerability
Dysregulated stress response has been linked to multiple health issues, yet the brain and body dynamics of acute stress remain poorly understood. Developing interpretable models is imperative in understanding this complex interplay. The present study sought to decode acute stress response by using…
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Journal Article
Early-life adversity in rodents: Experimental design is of the essence
Early-life adversity (ELA) is a well-documented risk factor for the development of psychiatric illnesses. Prospective investigations in humans are complex and limited in their ability to study the underlying neurobiological mechanisms, which is why many have reverted to animal models to examine the…
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Journal Article
Social touch-like tactile stimulation alleviates stress-induced anxiety-like behavior by enhancing the oxytocin level in the prefrontal cortex
Stress is a major contributor to the development and exacerbation of anxiety disorders. While social support is known to provide a buffering effect, the specific mechanisms remain poorly understood. This study investigated the neurobiological basis through which social touch alleviates…
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Journal Article
IBS stress reactivity phenotype is associated with blood transcriptome profiles and microstructural and functional brain changes
Evidence suggests significant interindividual differences in stress reactivity (SR), but mechanisms and therapeutic implications of these differences are poorly understood. The aim of this study was to identify the biological basis of increased SR by investigating associations between a…
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Journal Article
Amygdala reactivity to social stress in young adults: A scoping review of neuroimaging studies
Introduction: Social stress substantially influences emotional and cognitive functioning and is a key contributor to vulnerability for stress-related psychopathology in young adults. The amygdala plays a central role in mediating neural responses to socially evaluative stressors. Although prior…