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Regenerative Therapy
Scopus
ISSN 2352-3204 · Elsevier · 1.073 artikel di indeks
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Artikel Jurnal
Effect of local administration of microRNA-31/210 on bone regeneration surrounding hydroxyapatite/tricalcium phosphate -coated titanium implant in an ovariectomized rat model
Background: With the aging population, the prevalence of total joint arthroplasty in older adults with compromised bone conditions, such as osteoporosis, is increasing, raising concerns on the initial fixation of implants and aseptic loosening. Recent studies have highlighted the potential of…
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Artikel Jurnal
Best evidence summary for platelet-rich plasma treatment of chronic wounds
Objective: To summarize the best evidence for platelet-rich plasma therapy in chronic wounds, providing an evidence-based foundation for standardizing its clinical practice. Methods: Guided by the “6S” evidence pyramid model, we systematically searched 12 databases including Cochrane Library and…
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Artikel Jurnal
Recent progress in immunomodulation-based strategies for bone repair
Bone regeneration is a highly coordinated process shaped by the interplay between immune responses and osteogenic mechanisms. Immune cells such as neutrophils, macrophages, T cells, and B cells dynamically regulate the local microenvironment through cytokine secretion and signaling pathways…
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Artikel Jurnal
Microbial contamination risks and clinical safety in platelet-rich plasma therapy and evaluation of rapid microbial detection methods
Introduction: Platelet-rich plasma (PRP) is widely used for pain relief, wound healing, and so on. However, recent reports have documented cases of infections occurring after PRP therapy. In this study, we aimed to examine potential microbial contamination risks associated with PRP therapy and…
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Artikel Jurnal
Butyrate-preconditioned human adipose-derived stem cell-conditioned medium enhances myocardial perfusion after infarction
Introduction: Adipose-derived stem cell-conditioned medium (ASC-CM) is promising for cardiac repair via paracrine mechanisms. However, variability in efficacy limits its clinical translation. We investigated whether preconditioning human ASC with butyrate (ASC-BA-CM) enhanced its paracrine potency…
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Artikel Jurnal
From scaffold to function: A systematic review on dLECM-based hydrogels for liver tissue engineering — Fabrication, properties, and translational applications
Background: Liver tissue engineering is a rapidly advancing field aiming to address the critical shortage of donor organs and improve in vitro models for drug screening and disease modeling. Decellularized liver extracellular matrix (dLECM)-based hydrogels have emerged as a leading biomaterial…
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Artikel Jurnal
Wharton's jelly mesenchymal stem cell-secretome enhances skin rejuvenation via ApoA4 and SERPINH1
Introduction: Skin aging arises from intrinsic processes and extrinsic insults (e.g., ultraviolet exposure and oxidative stress). Mesenchymal stromal cell (MSC)-derived secretome offers a cell-free approach to skin regeneration. Wharton's jelly-derived MSCs (WJ-MSCs) may outperform adipose-derived…
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Artikel Jurnal
Mesenchymal stromal cell administration promotes macrophage-mediated bile duct regeneration
Introduction: Mesenchymal stromal cell (MSC) therapy is used in cirrhosis models of chronic hepatocellular damage and represents a novel therapeutic approach for liver regeneration. However, no studies have examined MSC therapy for bile duct injury and its effects on bile duct regeneration. This…
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Artikel Jurnal
Regulatory insights on adeno-associated virus-based gene therapies, cell- and tissue-based products, and CAR-T cell therapies: report from the 8th Asia Partnership Conference of Regenerative Medicine, April 24, 2025
The 8th Asia Partnership Conference of Regenerative Medicine (APACRM) was held in a hybrid format—both in person and online—on April 24, 2025, to advance regulatory harmonization for regenerative medicine products across Asia. Understanding the domestic regulatory guidelines and their underlying…
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Artikel Jurnal
Genomic analysis of dental pulp mesenchymal stromal cells for therapeutic applications
Introduction: Changes in cell characteristics and the accumulation of gene mutations during expansion culture present significant challenges for the clinical translation of stem cell transplantation technologies. Reduced cell quality may lead to diminished therapeutic efficacy and unexpected…
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Artikel Jurnal
Sustained release of quercetin through homogeneous poly (lactic-co-glycolic acid) microspheres to enhance MSCs biofunctions for regenerative therapy
Introduction: Mesenchymal stem cells (MSCs) hold significant potential for tissue repair and cell therapy. A primary obstacle in their application is the loss of stemness and onset of senescence during in vitro expansion, which compromises therapeutic efficacy. Plant-derived bioactive compounds…
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Artikel Jurnal
Role of WIF-1 in regulating chondrocyte dedifferentiation and matrix production through WNT pathway
Introduction: Chondrocyte dedifferentiation during monolayer expansion is a major barrier to producing clinically reliable cells for cartilage regeneration. The upstream regulators governing this phenotypic instability are not fully defined. This study identifies WNT inhibitory factor 1 (WIF1) as a…
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Artikel Jurnal
Innovative synergy of bone xenograft and quercetin in the alveolar bone socket: Histological and immunohistochemical assessment of healing
Background: After an extraction, the alveolar bone may undergo shrinkage, making it more challenging to place dental implants and compromising the appearance of prosthetic rehabilitation. Studies show that alveolar bone resorption could reach 50% of the original ridge width within the first six…
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Artikel Jurnal
Abnormal circ-CDK8 expression affects periodontitis development by regulating let-7b-5p/MAP4K3 signaling
Periodontitis, a chronic inflammatory disorder characterized by progressive alveolar bone loss, relies heavily on the osteogenic differentiation capacity of periodontal ligament stem cells for bone regeneration. While inflammatory conditions are known to impair this osteogenic potential, the…
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Artikel Jurnal
Prednisolone attenuates the immunomodulatory capacity and reshapes the functional phenotype of canine adipose-derived mesenchymal stromal cells
Introduction: Mesenchymal stromal cells (MSCs) are a promising therapeutic option for refractory canine chronic inflammatory enteropathy (CIE), primarily because of their immunomodulatory properties. However, MSC function may be influenced by concomitant medications, including prednisolone…
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Artikel Jurnal
Comprehensive regulatory and developmental landscape of cell–scaffold combination therapies for osteoarthritis
Introduction: Osteoarthritis (OA) is a common degenerative joint disease with rising prevalence in aging population. Regen-erative approaches such as autologous chondrocyte implantation (ACI) and stem cell-based therapies show promise but face limitations due to reduced cell viability and poor…
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Artikel Jurnal
Adipose-derived microvascular fragments: Functional microtissue units driving vascular integration and multidimensional tissue regeneration
Rapid and stable vascularization remains one of the major challenges in regenerative medicine and tissue engineering. Adipose-derived microvascular fragments (ad-MVFs) have emerged as a promising vascularization strategy because they preserve intact microvascular architecture while retaining…
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Artikel Jurnal
Stem cell senescence as a regenerative bottleneck in age-related skeletal degeneration: Mechanistic crosstalk and translational strategies
Skeletal degeneration is a major cause of pain, disability, fragility fracture, and loss of independence in aging populations. Although osteoporosis, osteoarthritis, and intervertebral disc degeneration are usually managed as anatomically separate disorders, they share a common regenerative…
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Artikel Jurnal
Ambient intelligence-based framework for quantitative evaluation of cell culture operations to support standardization and training
Introduction: The widespread implementation of cell therapy has increased the demand for stable and reproducible cell manufacturing methods. However, many cell manufacturing processes rely heavily on manual cell culture operations, and operator training remains largely dependent on subjective…
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Artikel Jurnal
Pilot study of Wilms tumor 1-targeted human platelet lysate-induced antigen-presenting cells in advanced solid cancer patients
Introduction: For the wide implementation of dendritic cell-based cancer immunotherapy, a clinical phase I study was conducted to explore its safety and tolerability using Wilms’ tumor 1 (WT1) antigen-targeted human platelet lysate-induced antigen-presenting cells (WT1-HPL-APCs), developed by our…
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