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Cellular and Molecular Gastroenterology and Hepatology
Scopus
ISSN 2352-345X · Elsevier · 1.546 artikel di indeks
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Artikel Jurnal
Ubiquitination of Rhomboid 5 Homolog 2 by Constitutive Photomorphogenic 1 Alleviates Hepatic Ischemia-reperfusion Injury by Regulating the Transforming Growth Factor-β Activating Kinase 1-C-Jun N-terminal Kinase/p38 Signaling PathwaySummaryWhat You Need to Know
Background & Aims: Hepatic ischemia-reperfusion injury (HIRI) is one of the common complications of liver transplantation. Rhomboid 5 homolog 2 (Rhbdf2) plays a crucial role in apoptosis, inflammation, and liver injury, but its role and regulatory mechanism in HIRI remain unclear. The aim of this…
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Artikel Jurnal
Prevention of Cholestatic Liver Disease Through BCL6-FXR Enterohepatic CrosstalkSummaryWhat You Need to Know
Background & Aims: Bile acid (BA) metabolism must be tightly regulated because BAs serve as metabolic signaling molecules but become cytotoxic at high levels. The farnesoid X receptor (FXR) is a crucial BA sensor, yet our understanding of its regulation and coordination with other transcription…
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Liver Sinusoidal Endothelial Cells Promote Metabolic Dysfunction-associated Steatohepatitis Progression via Interleukin-1R1-mediated Chemokine Production Induced by Macrophage-derived Interleukin-1βSummaryWhat You Need to Know
Background & Aims: Interleukin (IL)-1β is a key cytokine in hepatitis-related inflammation, but its role in metabolic dysfunction-associated steatotic liver disease (MASLD) or steatohepatitis (MASH) remains unclear. This study investigated IL-1β-mediated interactions in nonparenchymal liver cells…
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Artikel Jurnal
Local Interactions Between Innate Immune Signaling, Microbiota, and Bile Acids Drive the Development of Duodenal AdenomasSummaryWhat You Need to Know
Background & Aims: Duodenal adenomas have malignant potential, yet the drivers of duodenal tumorigenesis remain unclear. Duodenal adenomas robustly develop in villin- Toll-like receptor 4 (TLR4) mice, a transgenic mouse model of increased innate immune signaling in the intestinal epithelium. Here…
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Metabolic Signatures of Acinetobacter baumannii and Klebsiella pneumoniae Infections in Acute-on-chronic Liver FailureSummaryWhat You Need to Know
Background & Aims: Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome of acute hepatic decompensation (AD) that leads to multiorgan failure and high mortality. Bacterial infections are often implicated in ACLF pathogenesis; however, their underlying molecular mechanisms remain…
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Artikel Jurnal
Thymic Stromal Lymphopoietin–Driven B-Cell Hyperactivation Impairs Intestinal Epithelial Homeostasis Predisposing to Enterocolitis in Hirschsprung DiseaseSummaryWhat You Need to Know
Background & Aims: Hirschsprung-associated enterocolitis, a lethal complication of Hirschsprung’s disease—a prevalent congenital disorder with high morbidity—has a poorly understood pathogenesis. We investigated how aberrant immune–stromal crosstalk drives mucosal injury in Hirschsprung’s disease…
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Artikel Jurnal
Prostanoids in Liver Repair and Regeneration: Biosynthesis, Receptors, and Intercellular CommunicationSummary
Prostanoids typically refer to prostaglandins, prostacyclin, and thromboxane, and are a series of bioactive lipid mediators primarily derived from arachidonic acid. Prostanoids play pivotal roles in various physiological processes, including liver repair and regeneration. Liver cells can produce…
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Artikel Jurnal
A Myeloid Lineage Signifying Anti-tumor Necrosis Factor Resistance in Crohn’s DiseaseSummary
Background & Aims: Although anti-tumor necrosis factor (TNF) therapy has improved Crohn’s disease (CD) management, the development of a refractory phenotype having resistance to the drug is not uncommon. The mechanisms behind this anti-TNF nonresponse are unknown but are likely multifactorial…
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Artikel Jurnal
R-Spondin1 Regulates Fate of Enteric Neural Progenitors via Differential LGR4/5/6 Expression in Mice and HumansSummary
Background & Aims: Regeneration and cytodifferentiation of various adult epithelial stem cell compartments are controlled by the WNT agonist R-Spondin1 (RSPO1) and the Leucin-rich-repeat-containing G-protein-coupled receptors (LGR4/5/6). We hypothesized that RSPO1-LGR signaling is also involved in…
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Artikel Jurnal
Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ PathwaySummary
Background & Aims: Intraductal tubulopapillary neoplasm (ITPN) is a rare, high-grade tumor of the pancreatic duct, characterized by distinct molecular features including frequent alterations in the components of switch/sucrose nonfermenting (SWI/SNF) chromatin remodeling complex and PI3K/AKT…
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Artikel Jurnal
EP300/YAP1-SERPINE1 Signaling Regulates Ductular Reaction and Liver Fibrosis in Biliary AtresiaSummary
Background & Aims: Biliary atresia (BA) is the most prevalent cholestatic liver disorder that affects infants. BA is characterized by ductular reaction (DR) and liver fibrosis (LF). The mechanistic basis for DR and LF induction in BA is unknown. In this study, we examined the molecular signals…
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Artikel Jurnal
A Single-Cell Atlas of Transcriptome Changes in the Intestinal Epithelium at the Suckling-to-Weaning Transition in Male RabbitsSummary
Background & Aims: The suckling-to-weaning dietary transition is a key step in intestinal development. The aim of our study was to identify the transcriptome changes induced in each cell type of the intestinal epithelium at the onset of solid food ingestion. Methods: We compared the single-cell…
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Artikel Jurnal
Macrophage Nogo-B Drives Liver FibrosisSummary
Background & Aims: Liver fibrosis is characterized by sustained injury stress, chronic inflammation, and repeated cell death and repair, all of which promote the progression of end-stage liver diseases (eg, liver cirrhosis and carcinoma). As an endoplasmic reticulum-residential protein, Nogo-B…
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Artikel Jurnal
Ablation of Sympathetic Nerve-β3 Adrenergic Receptor-mediated Adipose Tissue Lipolysis Attenuates Alcohol-induced Liver Injury in MiceSummary
Background & Aims: Binge drinking causes fat accumulation in the liver and is a known risk factor for more severe forms of alcohol-associated liver disease (ALD). Although adipocyte-released free fatty acids (FFA) have been shown to contribute to alcohol-induced liver damage, the signaling pathways…
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Artikel Jurnal
Barrington’s Nucleus: A Pontine Defecation Brain Area Exhibiting Prompt and Delayed Defecation ResponsesSummary
Background & Aims: Chronic constipation has attracted considerable attention because of its negative impact on quality of life. Although defecation depends on local anorectal motility coordinated by the central nervous system, how it is regulated by the brain remains unclear. Methods: Brain areas…
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Artikel Jurnal
Interleukin-4-mediated Pro-Regenerative Cellular Reprogramming in 3-dimensional Liver CultureSummary
Background & Aims: Interleukin-4 (IL-4) is a key contributor to liver regeneration, but its effects remain poorly understood due to a lack of models that preserve the complex cellular interactions of the liver. Here, we use murine precision-cut liver slices (PCLS), a 3-dimensional tissue culture…
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Artikel Jurnal
Glycogen Synthase Kinase 3 β Hepatocyte Deletion Attenuates Ferroptosis and Metabolic Dysfunction-associated Steatohepatitis in MiceSummaryWhat You Need to Know
Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by toxic lipid-induced cellular stress (lipotoxicity), which culminates in lethal and sublethal hepatocyte injury and a sterile fibroinflammatory response. We previously reported that pharmacological…
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