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EBioMedicine
Scopus
ISSN 2352-3964 · Elsevier · 5,514 articles in the index
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Journal Article
Breastfeeding, bonding, and olfaction: unlocking the potential of mother-infant odour exchange
Summary: Breastfeeding is crucial for infant survival, growth, and health, and it enhances maternal-infant bonding and well-being. However, breastfeeding rates typically fall below international targets, partly due to a high prevalence of latching difficulties, intermittent sucking, refusing the…
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Journal Article
Elevated SARS-CoV-2 IgG4 in plasma and mucosa following repeated mRNA boosters impact antibody functions to Omicron and sarbecovirusesResearch in context
Summary: Background: Elevated SARS-CoV-2 IgG4 levels following repeated COVID-19 mRNA boosters may impact blood and mucosal antibody functions against Omicron variants and sarbecoviruses. This study characterised the rise of IgG4 in blood and saliva following four consecutive COVID-19 mRNA doses…
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Journal Article
Projected extreme temperature event-attributable dementia deaths in China: a climate–ageing–adaptation frameworkResearch in context
Summary: Background: Climate change is increasing health risks worldwide, but how extreme temperature events affect Alzheimer's disease and other dementias (ADD) remains poorly understood. We aimed to project future extreme temperature event-attributable ADD deaths in China, accounting for the…
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Journal Article
Identification of genes underlying nigrostriatal iron accumulation: transcriptome-wide association study of iron-sensitive brain MRIResearch in context
Summary: Background: Nigrostriatal iron accumulation is a hallmark of ageing and neurodegenerative diseases, but the molecular mechanisms regulating iron deposition in the human brain remain unclear. Identifying genes linked to iron accumulation could reveal new pathways for neuroprotection and…
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Journal Article
Neoantigenic properties of TP53 variants influence cancer risk in individuals with Li-Fraumeni syndromeResearch in context
Summary: Background: Li-Fraumeni Syndrome (LFS) is a heterogenous cancer predisposition condition caused by pathogenic TP53 variants, characterised by a lifelong high risk of a broad spectrum of cancers. Certain pathogenic TP53 variants have been shown be immunogenic in a somatic context. Whether…
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Journal Article
PD-1 blockade enhances functional vaccine-induced HIV-1 CD8+ T-cell responses in PWH receiving early ARTResearch in context
Summary: Background: Immunotherapeutic strategies combining Immune checkpoint blockade (ICB) and therapeutic T-cell vaccination hold promise to enhance HIV-1 remission in people with HIV (PWH). While T-cell vaccination alone has shown limited efficacy, ICB may potentiate vaccine-induced T-cell…
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Journal Article
Sex-specific interaction effects of Syntaxin 1A coexpression network and childhood trauma on adult depressive symptomsResearch in context
Summary: Background: Disruptions in synaptic function and exposure to early life trauma are both implicated in the development of depression, though the underlying mechanisms remain poorly understood. Methods: To investigate this relationship, we developed an expression-based polygenic score (ePRS)…
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Journal Article
Multi-omics analyses identify potential epigenetic loci associated with survival in amyotrophic lateral sclerosis across diverse populationsResearch in context
Summary: Background: Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disease, with highly diverse survival time. However, genetic and epigenetic factors influencing ALS survival across diverse populations remain unclear. Methods: We performed whole-genome sequencing (WGS) and DNA…
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Journal Article
Epigenome-wide analysis in West Africans identifies DNA methylation markers for circulating adiponectinResearch in context
Summary: Background: Adiponectin is a circulating adipokine involved in energy metabolism and inflammation, with reported protective effects against cardiometabolic diseases such as type 2 diabetes (T2D) and early kidney disease. However, its regulation remains poorly understood. This study aimed…
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Journal Article
Serological and faecal markers of irritable bowel syndrome: a systematic review and meta-analysisResearch in context
Summary: Background: The irritable bowel syndrome (IBS) has long been considered a functional disorder, but recent work has demonstrated clear biological signatures in immune, microbiome and enteric nervous systems of patients with IBS. Despite this new knowledge, there is still no clear biological…
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Journal Article
Integrating breast tumour homologous recombination deficiency status to aid germline BRCA1 and BRCA2 variant classificationResearch in context
Summary: Background: Pathogenic germline variants in certain genes are associated with somatic tumour mutation signatures. The use of somatic tumour mutation data has the potential to improve the identification of true pathogenic variants but remains underexplored. We investigated the integration…
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Journal Article
Lack of harmonisation in immunological data: challenges in synthesising data during the COVID-19 pandemic
Summary: The COVID-19 pandemic drove the rapid development of assays to ascertain immune responses, and laboratories were required to adapt to difficult and quickly changing circumstances. While flexibility and innovation were essential, they also introduced heterogeneity in methods, reagents, and…
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Journal Article
The pathoanatomy of cancer: order in paradox
Summary: The pathoanatomy of local cancer spread is approached by the ontogenetic cancer field model, deduced from aspects of evolution, development, immunity, and wound healing/regeneration in multicellular animals, postulating: (1) Cancer cells canonically respond to the disruption of tissue…
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Journal Article
Modified hTERT treatment ameliorates pressure overload-induced heart failureResearch in context
Summary: Background: Heart failure (HF) is a currently incurable disorder that increases the risk for stroke and sudden cardiac death. Shortened telomeres have been linked to the development of cardiomyocyte abnormalities and dysfunction, and telomere reprotection has become a favourable strategy…
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Journal Article
Short tandem repeat expansions in patients with neurodegenerative dementiaResearch in context
Summary: Background: Due to the overlapping clinical features of neurodegenerative dementia (NDD)—including Alzheimer's disease (AD), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), and progressive supranuclear palsy (PSP), accurate diagnosis remains challenging in early stages…
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