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Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Scopus
ISSN 2352-8729 · Wiley · 1.222 artikel di indeks
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Artikel Jurnal
APOE and amyloid‐tau pathology in cognitively unimpaired older adults
Abstract INTRODUCTION Apolipoprotein E (APOE) genotype shows well‐established dose‐dependent associations with higher amyloid in cognitively unimpaired (CU) adults. In contrast, associations with tau burden and cognition are less well characterized. METHODS We performed a cross‐sectional analysis…
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Screening GGC repeat expansion in the NOTCH2NLC in early‐onset dementia: The Longitudinal Study of Early Onset Dementia and Family Members (LEAF) Study
Abstract BACKGROUND Neuronal intranuclear inclusion disease (NIID) is neurodegenerative disorder caused by GGC repeat expansion in NOTCH2NLC. Given its frequency in young East Asian adults and overlap with cognitive impairment in young adults, a key feature of early‐onset dementia (EOD), we…
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Plasma GFAP and language‐network tau mediate the effect of amyloid burden on semantic fluency: A mediation analysis
Abstract INTRODUCTION Amyloid burden may relate to semantic fluency through tau and astrocytic pathways, but their contributions remain unclear. METHODS In this cross‐sectional study, we analyzed 210 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with amyloid positron emission…
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Quantification of global gray matter amyloid‐β plaque from 18F‐Florbetaben PET/MRI and correlation to BAPL score in patients with cognitive impairment
Abstract INTRODUCTION Multiple standardized uptake value ratio (SUVR) and Centiloid (CL) thresholds exist for amyloid‑β (Aβ) positron emission tomography (PET) to classify scans as negative or positive, yet none reliably stratify brain amyloid plaque load (BAPL). This study proposes a global gray…
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Arterial stiffness and risk of dementia in late life: The ARIC neurocognitive study
Abstract INTRODUCTION Associations of arterial stiffness, measured through pulse wave velocity (PWV), with incident dementia may be driven by age‐related structural changes to the arterial wall or by elevated blood pressure. METHODS Dementia‐free White or Black participants in the community‐based…
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Obstacles and solutions for implementing amyloid‐targeting treatments in Europe
Abstract Recent approvals of disease‐modifying therapies by the European Medicines Agency mark a historic shift in the treatment landscape of Alzheimer's disease (AD) within the European Union that will challenge national health‐care systems and require major adaptations and modernization. This…
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Clinical utility of LUMIPULSE plasma p‐tau217 to identify amyloid positivity among candidates for amyloid‐targeting treatments in a real‐world cohort
Abstract INTRODUCTION Increasing clinical use of amyloid‐targeting treatments (ATTs) requires accessible biomarkers for Alzheimer's disease (AD). Although the utility of plasma phosphorylated tau 217 (p‐tau217) is well established in research cohorts and its use for identifying amyloid positivity…
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APOE ε4 and Alzheimer's disease biomarkers in an American Indian community
Abstract INTRODUCTION Apolipoprotein E (APOE) ε4's effect on Alzheimer's disease (AD) depends on ancestry and environmental risk factors. The APOE ε4–AD link in American Indian (AI) populations appears attenuated, with current understanding largely informed by a single research study. This study…
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AST/ALT, APOE ε4, and Alzheimer's disease progression: A longitudinal cohort study
Abstract INTRODUCTION The aspartate aminotransferase‐to‐alanine aminotransferase (AST/ALT) ratio is a routinely available liver‐enzyme index. Whether apolipoprotein E (APOE) ε4 modifies associations of baseline AST/ALT with longitudinal Alzheimer's disease (AD) trajectories is unclear. METHODS In…
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Harmonizing biofluid specimen collection and biomarker quantification in Diverse Vascular Contributions to Cognitive Impairment and Dementia (DVCID) study
Abstract INTRODUCTION Multicenter clinical studies inherently face challenges in maintaining consistency across sites. Here we share the design and implementation of standard operating procedures (SOPs) for the Diverse Vascular Contributions to Cognitive Impairment and Dementia (DVCID) study…
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Elecsys pT181p immunoassay: Clinical performance for ruling out amyloid pathology
Abstract INTRODUCTION Plasma biomarker rule‐out tests can be used early in the Alzheimer's disease (AD) diagnostic pathway to identify people with low likelihood of amyloid pathology. METHODS A care setting‐agnostic cutoff for the Elecsys® Phospho‐Tau (181P) plasma (pT181p) immunoassay was…
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Deep contrastive learning framework identifies cell‐type‐specific drug targets in Alzheimer's disease
Abstract INTRODUCTION Identifying disease‐modifying drug targets is crucial for developing effective Alzheimer's disease (AD) treatments. METHODS We present a deep contrastive learning framework for cell type‐specific AD‐associated genes identification (alzCL). alzCL creates cell‐type‐specific…
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Focal hippocampal subfield atrophy in cognitively impaired relative to cognitively unimpaired older adults is associated with memory ability
Abstract INTRODUCTION We assessed whole hippocampal and subfield volumes, in association with memory ability, in a sample including cognitively unimpaired (CU) older adults and those in early syndromic stages of pathological aging, here subjective cognitive decline (SCD) and mild cognitive…
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Regional amyloid accumulation, post‐traumatic distress, and intrusive symptoms in cognitively unimpaired older adults at risk for Alzheimer's
Abstract INTRODUCTION In preclinical Alzheimer's disease (AD), early pathology may heighten vulnerability to psychiatric symptoms. We examined whether Aβ accumulation in cognitive‐emotional regions was associated with post‐pandemic psychiatric symptoms. METHODS This prospective cohort study…
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Deep learning‐based cortical thickness maps for diagnosis of neurodegenerative diseases: a rater study
Abstract INTRODUCTION Cortical atrophy patterns on magnetic resonance imaging (MRI) are essential for diagnosing neurodegenerative diseases (NDs), but remain challenging to assess visually. Deep learning enables quantitative evaluation of cortical thickness (CTh) and z‐score maps. METHODS 3T…
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Real‐world determinants of time to initiation of anti‐amyloid treatments: comparative data from private and academic practice settings
Abstract INTRODUCTION Earlier anti‐amyloid therapy (AAT) initiation results in improved clinical outcomes in Alzheimer's disease (AD). We sought to identify demographic, clinical, and disease‐related factors impacting door‐to‐treatment times (DTTs). METHODS A retrospective review of AAT data was…
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Linking cognitive variability and Alzheimer's disease biomarkers by neurocognitive status
Abstract INTRODUCTION This study aimed to assess intra‐individual cognitive variability (IICV) in relation to Alzheimer's disease (AD) biomarkers. METHODS The National Alzheimer's Coordinating Center sample (n = 879), aged 50+ with a complete neuropsychological evaluation and AD biomarker data…
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Comparison of a multi‐analyte algorithmic immunoassay blood test with immunoprecipitation mass spectrometry for the detection of amyloid pathology
Abstract INTRODUCTION Alzheimer's blood‐based biomarker (BBM) tests using single biomarkers or ratios are well characterized, but head‐to‐head comparisons of multi‐analyte algorithmic tests on shared cohorts are lacking. We compared a five‐biomarker algorithmic immunoassay (LucentAD Complete) with…
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Helicobacter pylori, herpes simplex virus‐1, varicella‐zoster virus, and dementia risk
Abstract Introduction Helicobacter pylori (H. pylori), herpes simplex‐1 (HSV‐1), and varicella‐zoster virus (VZV) could increase dementia risk; however, evidence from large cohorts with long‐term follow‐up is scarce. Methods Multivariable‐adjusted Cox proportional‐hazards models were used to…
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Life's Essential 8™ and incident dementia in an urban cohort: Findings from the Northern Manhattan Study
Abstract INTRODUCTION The American Heart Association's Life's Essential 8™ (LE8) defines cardiovascular health (CVH) using eight behavioral and clinical metrics. We examined the association between CVH and incident dementia. METHODS We used data from 920 dementia‐free participants of the Northern…
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