874 results

Memantine, acetylcholinesterase inhibitors, and quality‐of‐care outcomes among patients with cognitive impairment: an emulated trial design

Erin L. Ferguson; Jingxuan Wang; Justin S. White et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION We evaluated the effect of acetylcholinesterase inhibitors (AChEIs) and memantine on non‐cognitive outcomes by implementing emulated trials in electronic health records. METHODS Individuals diagnosed with cognitive impairment who initiated AChEIs or memantine were matched to…

Hippocampal mediation in the lipid–Alzheimer's disease pathway: A high‐dimensional mediation analysis stratified by APOE and sex

Yunjia Cao; Yuwei Fan; Qingtao Meng et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION Systemic lipid dysregulation is a modifiable risk factor for Alzheimer's disease (AD), yet the neuroanatomic pathways through which specific lipids influence AD progression remain poorly delineated. We investigated whether brain structure mediates the relationship between…

Effect of choline supplementation in presymptomatic APOE ε4 carriers: a pilot study

William J. Ray; Yaima L. Lightfoot; Ronnie T. Trinh et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION With the advent of early detection biomarkers, it is possible to envision testing preventive strategies that delay the onset of Alzheimer's disease (AD). The ε4 allele of apolipoprotein E (APOE ε4) is the strongest genetic risk factor for late‐onset AD; approximately 50% of…

Humanized APP is the primary determinant of regional brain volume in humanized APOE knock‐in mice: a cross‐sectional ex vivo MRI study

Avnish Bhattrai; Adam C. Raikes; Roberta Diaz Brinton

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION Age, Apolipoprotein ε4 (APOE4) genotype, and biological sex are major risk factors for late‐onset Alzheimer's disease (LOAD), and preclinical mouse models enable controlled investigation of these factors. To date, humanized APOE4 has not recapitulated LOAD‐relevant brain…

Remote digital cognitive assessment in a trial‐ready Alzheimer's disease cohort: A scalable approach for early intervention studies

Andrew J. Aschenbrenner; Hannah Wilks; Matthew Welhaf et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

ABSTRACT INTRODUCTION Early detection of cognitive decline in Alzheimer's disease (AD), particularly in preclinical stages, is critical for evaluating therapeutic interventions. Traditional cognitive assessments often require lengthy in‐person visits, and may therefore limit scalability for…

Effects of long‐term daily supplementation with vitamin D3 and marine omega‐3 fatty acids on change in ADRD biomarkers: A secondary analysis of a randomized clinical trial

Chirag M. Vyas; Beth L. Ostaszewski; Amirah K. Anderson et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION Vitamin D3 and omega‐3 supplementation may slow outcomes related to Alzheimer's disease and related dementias (ADRD), with variation by sex or race, but their effects on ADRD‐associated biomarkers are unknown. METHODS In this secondary analysis of a randomized clinical trial…

Cerebrospinal fluid protein elevations in Alzheimer's disease are dissociated from immune cell composition

Sina Zaic; Theresa König; Omar Keritam et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION Elevated cerebrospinal fluid (CSF) inflammatory proteins have been reported in Alzheimer's disease (AD), yet whether they reflect peripheral immune cell infiltration or central nervous system (CNS)–intrinsic pathological processes remains unclear. We tested whether AD exhibits…

Dementia progression with GLP‐1 receptor agonists in people with mild cognitive impairment and type 2 diabetes: target‐trial emulation study

Meir Schechter; Dvora R Sehtman‐Shachar; Alisa Fishkin et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION In people with type 2 diabetes (T2D) without dementia, glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) improved cardiovascular, kidney, and mortality outcomes, with multiple real‐world studies suggesting reduced risk of dementia onset. However, the EVOKE/EVOKE+…

What is new in delirium: A vascular etiology outlook

Niccolò Terrando; Mervyn Maze; Ting Yang

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract Emerging studies have highlighted the vascular contributions to cognitive impairment and dementia (VCID), especially in the context of neurodegenerative disorders that cause cognitive decline (i.e., Alzheimer's disease and related dementias [ADRD]). More recent research on perioperative…

Factors associated with phlebotomy failure in an Alzheimer's Disease Research Center cohort

Mary Catherine Pawlus; Anna Gorham; Claudia Suarez‐Rodriguez et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION Venous blood collection through phlebotomy is critical for biomarker development and genetics research on Alzheimer's disease (AD) and related dementias. In this research setting, phlebotomy is often performed by clinical research coordinators (CRCs) rather than professional…

Understanding dementia in Filipino Americans: risk factors, research gaps, and the role of community‐based participatory research

Rochelle‐Jan Dionisio Reyes; Ariel Guevarra; Eugenie Mamuyac et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract Filipino Americans are the third‐largest Asian American, Native Hawaiians, and Pacific Islander (AANHPI) group in the United States. Previous studies showed that they have high incident rates of Alzheimer's disease and related dementias (AD/ADRD) compared to other AANHPI groups. However…

Baseline plasma C1q and C3 as potential biomarkers for lecanemab efficacy and ARIA risk in early Alzheimer's disease

Gihwan Byeon; Jung‐Won Lee; Suhyung Kim et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION The classical complement cascade has been implicated in amyloid beta (Aβ) clearance and in the pathogenesis of amyloid‐related imaging abnormalities (ARIA) during anti‐amyloid monoclonal antibody therapy. Clinically accessible peripheral biomarkers of this cascade remain…

Agentic neurotechnology: A multi‐agent AI framework for next‐generation dementia care

Kevin Mekulu; Faisal Aqlan; Hui Yang

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract Dementia care is reaching a technological turning point as rapid advances in artificial intelligence (AI), digital biomarkers, and sensor‐based monitoring continue to outpace current clinical practice. Yet most tools remain episodic and disconnected from the everyday environments where…

Meeting report for the Second International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging (UAMAA 2026)

Jane Alshami; Ginny Wu; B. Maximiliano Garduño et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract The Second International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging (UAMAA 2026) was held February 9 through 11, 2026, in Irvine, California. Building upon the inaugural meeting in Santiago, Chile (2023), this conference expanded an international effort to…

Response to “Reanalyzing the impact of cognitive training over 20 years in the ACTIVE study: Losing the forest in the trees”

Alden L. Gross; George W. Rebok; Marilyn S. Albert

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Association of SPHK1 polymorphisms with Alzheimer's disease susceptibility: Functional impact of the rs2247856 SNP on transcriptional efficiency

Dong‐Ju Kim; Yong‐Chan Kim; Byung‐Hoon Jeong

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION Sphingosine kinase 1 (SPHK1) has been implicated in the regulation of pro‐resolving lipid mediators relevant to neuroinflammation in Alzheimer's disease (AD). However, no studies have evaluated the genetic association between SPHK1 polymorphisms and AD susceptibility. METHODS…

Factors affecting representativeness in home‐based dementia activity interventions: a literature review

Jiska Cohen‐Mansfield

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract Most persons living with dementia (PLwD) reside in community settings, which has driven the development of a wide range of home‐based activity interventions. However, the external validity of these studies remains uncertain because the representativeness of study samples is rarely…

Clinically altered brain activity may not look like aged brain activity: Implications for brain‐age modeling and biomarker strategies

Lukas A. W. Gemein; Sinead Gaubert; Claire Paquet et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION Brain‐age gap (BAG), the difference between predicted age and chronological age, is studied as a biomarker for the natural progression of neurodegeneration. The BAG captures brain atrophy as measured with structural magnetic resonance imaging (MRI). Electroencephalography…

Associations between neuronavigated rTMS‐mediated functional connectome plasticity and neurotransmitter receptors in Alzheimer's disease

Weina Yao; Tingyu Lv; Wenao Zheng et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION Cognitive improvement is mediated by repetitive transcranial magnetic stimulation (rTMS) in Alzheimer's disease (AD), and connectome gradient analysis has important potential to explore more comprehensive information for treatment efficacy. However, it remains unclear whether…

Engaging Hispanic/Latino young adults in Alzheimer's disease research through boot camp translation

Michelle N. Martinez; Stacey Moeller; Mirna Arroyo‐Miranda et al.

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol. 12 No. 3 · 2026 · English · DOAJ Scopus

Abstract INTRODUCTION Despite increased risk for Alzheimer's disease and related dementias (ADRDs), Hispanic/Latino (H/L) populations remain underrepresented in research due to several barriers (e.g., stigma, health literacy). Considering family dynamics and cultural values, young H/L individuals…