297 hasil
Menampilkan 1–20 · 0,17 detik · RSS
OpenNano
Scopus
ISSN 2352-9520 · Elsevier · 297 artikel di indeks
-
Artikel Jurnal
Scaling up nanoformulation manufacturing: A multi–case study linking target product profiles, critical quality attributes, and quality by design
Nanoformulation platforms have transformed drug delivery; however, reliable scale-up from laboratory to manufacturing remains the principal barrier to clinical translation. This review integrates target product profile (TPP)–driven requirements with critical quality attributes (CQAs)…
-
Artikel Jurnal
Obesity-associated pathologies: Recent advances in stimuli-responsive nanocarriers for adipose tissue browning and beyond
Obesity is a chronic multifactorial disorder affecting more than 600 million people worldwide. It is initially caused by an imbalance between energy intake and consumption, and it is strongly correlated to many chronic and life-threatening disorders such as cardiovascular diseases, digestive…
-
Artikel Jurnal
Spacer-engineered carboxylated curdlan derivatives for dendritic cell activation and cancer immunotherapy
Effective cancer immunotherapy requires cytosolic delivery of antigens into dendritic cells together with their maturation to elicit robust cellular immunity. Conventional vaccine carriers often combine multiple components to achieve both adjuvant activity and antigen delivery, which increases…
-
Artikel Jurnal
Microalgae-derived biomolecule and nanoparticle conjugates: Emerging therapeutic platforms for cancer treatment
Nanoparticle-based drug delivery systems have the potential to provide a promising platform for overcoming the limitations of therapeutics in cancer treatment, thanks to advantages such as controlled release, tumor targeting, and reduced systemic toxicity. In parallel, microalgal biomolecules…
-
Artikel Jurnal
Flexible asymmetric liposomes as a platform for improved plasmid DNA delivery: An in vitro study
As a versatile type of nanocarrier, liposomes have gained attention due to their biocompatibility, biodegradability, and ability to encapsulate a wide range of compounds. Asymmetric liposomes are characterized by distinct lipid compositions in their inner and outer layers, enhancing drug…
-
Artikel Jurnal
Investigation of safety and efficacy of ZnO nanoparticle-loaded alginate-hyaluronic acid hydrogel for wound dressings: In vitro and in vivo studies
The integration of nanotechnology and biomaterials is valuable for the future of wound care. However, concerns regarding the biosafety of the nanoparticles remain unresolved. This study aims to evaluate the activity and safety of the alginate-hyaluronic acid (Alg/HA) hydrogel-loaded zinc oxide…
-
Artikel Jurnal
Eco-friendly synthesis of nitrogen-doped carbon dots from Cochlospermum regium for efficient photocatalytic removal of pharmaceutical contaminants and antibacterial performance
Nitrogen-doped carbon dots (NCDs) were successfully synthesized from Cochlospermum regium petals via a facile hydrothermal method using L-phenylalanine as a nitrogen source. The structural, morphological, optical, and electrochemical properties of the prepared materials were systematically…
-
Artikel Jurnal
Natural nanocarriers in oncology: The targeting and delivery capabilities of extracellular vesicles
Extracellular vesicles (EVs) are nanoscale structures naturally released by cells that mediate intercellular communication by transporting bioactive cargo, including nucleic acids, proteins, and lipids. Their natural origin provides high biocompatibility, low immunogenicity, enhanced stability in…
-
Artikel Jurnal
Transfersomal gel loading of amniotic mesenchymal stem cell metabolite product for diabetic wound healing in alloxan-induced diabetic mice
Purpose: Amniotic mesenchymal stem cell metabolite product (AMSC-MP), a metabolite derived from cell cultures, contains cytokines and growth factors that support skin regeneration, making it a promising therapeutic candidate for chronic wounds, such as diabetic foot ulcers. However, because of…
-
Artikel Jurnal
Formulation, characterization, and valorization of the antioxidant, antibiofilm, and anti-adhesion potentials of a clove essential oil nanoemulsion
Food safety and control are fundamental public health issues that maintain consumer confidence and protection. This design (management) requires monitoring production, processing, and conservation processes while limiting microbiological, chemical, and physical risks. In this context, clove…
-
Artikel Jurnal
Development and in vitro evaluation of self-emulsifying drug delivery systems liquisolid lozenges of ibuprofen via design of experiments for solubility enhancement and oral epithelial cell permeation
Ibuprofen lozenges were developed by converting liquid self-emulsifying drug delivery systems (L-SEDDS) into liquisolid compacts (LSCs) to enhance aqueous solubility, support local anti-inflammatory action in the oral and throat regions, and reduce gastrointestinal irritation. The solubility of…
-
Artikel Jurnal
Development of new delivery systems of hyaluronic acid based on silica hydrogels: In vitro kinetics of release and enzymatic degradation of the drug
Hyaluronic acid (HA) is a well-known anti-inflammatory drug that is widely used clinically to treat various diseases and as a component in cosmetic products. However some properties of HA (rapid release and enzymatic degradation) significantly reduce its functioning in the body and, consequently…
-
Artikel Jurnal
Enantiomeric lysine-based cationic lipids: Design, synthesis, and characterization for in vitro gene delivery
Nucleic acid delivery is crucial for gene therapy, vaccination, and cancer treatment. Despite advances in cationic lipid-based vectors, their transfection efficiency is often limited by structural complexity. In this study, we synthesized lysine-based cationic lipids by esterifying d- or l-lysine…
-
Artikel Jurnal
Proteomics-guided characterization of
Biological synthesis offers an alternative approach for producing silver nanoparticles (AgNPs) using naturally derived biomolecules. In this study, a protein-rich extract of Hericium erinaceus (PHEx) was used for the biosynthesis of protein-capped AgNPs, followed by physicochemical, proteomic…
-
Artikel Jurnal
Development and biological evaluation of Sericin–Chitosan nanohydrogel for modulating bone remodeling in orthodontic relapse
Orthodontic relapse remains a clinical concern because periodontal and alveolar tissues continue to reorganize after active tooth movement. In this proof-of-concept study, we developed a Sericin–Chitosan nanohydrogel and examined its effect on early post-orthodontic bone remodeling using bone…
-
Artikel Jurnal
Electrostatically tunable metronidazole-loaded chitosan/pectin polyelectrolyte complex nanoparticles: Charge ratio–dependent self-assembly and drug delivery performance
Chronic wounds require dual-action therapies capable of managing localized microbial burdens while simultaneously promoting tissue regeneration. Although metronidazole (MTZ)-loaded chitosan/pectin (CS/Pec) polyelectrolyte complex (PEC) nanoparticles have been previously documented, the precise…
-
Artikel Jurnal
Sericin-Capped Gold Nanoparticles as a Potential Antimicrobial in Human Urine through Disrupting Bacterial Membranes and Changing Metabolism
Catheter-associated urinary tract infection (CAUTI) is a prevalent healthcare-associated infection, necessitating alternative therapeutic strategies. Sericin-conjugated gold nanoparticles (AuNP-Sericin) offer broad antibacterial and biomedical potential, leveraging gold nanoparticles' inertness and…
-
Artikel Jurnal
Anti-obesity therapeutics through the application of nanostructures in murine models: a systematic review
Obesity is a highly prevalent chronic disease, and lifestyle-based interventions often show limited long-term efficacy. Nanotechnology has emerged as a preclinical strategy to improve the bioavailability, stability, tissue delivery, and metabolic activity of anti-obesity agents. This systematic…
-
Artikel Jurnal
Boronic acid and piperine-derived Carbon dots for inhibition and eradication of bacterial biofilm
Bacterial biofilms are a major cause of persistent infections owing to their high tolerance to antimicrobial agents and host immune responses. In this study, two boron-functionalized carbon dots (CDs), boronic acid-derived carbon dots (BACD) and piperine/boronic acid-derived carbon dots (PPCD)…
-
Artikel Jurnal
Stimuli-responsive nanoparticles in 3D–4D printing for drug delivery: practical considerations and challenges in clinical translation
Stimuli-responsive nanoparticles (SR NP) enable drug release triggered by internal (pH, redox, enzymes) or external (light, magnetic) stimuli, thereby enhancing therapeutic efficacy while reducing adverse effects. However, conventional nanoparticle fabrication methods lack precision…