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Archives of Pharmaceutical Sciences Ain Shams University
ISSN 2356-8380 · Ain Shams University · 228 artikel di indeks
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Artikel Jurnal Teks lengkap
“Precision Targeted and Combination Therapies in AML: Confronting Resistance with Multi-Pathway Inhibition”
Acute myeloid leukemia (AML) is a genetically complex and heterogeneous aggressive cancer in which targeted therapies have improved outcomes but are often limited by induced resistance. This review provides a comprehensive and mechanistically driven overview of the molecular subclasses of AML…
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Antimicrobial Peptides from Natural Sources: Emerging Weapons Against Antimicrobial Resistance
The world is currently struggling with the obstacle of antibiotic resistance, which represents a threat to health, the economy, and other aspects because of the abuse and misuse of antibiotics. By 2050, antimicrobial resistance (AMR) is anticipated to be responsible for approximately 10 million…
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Neurobiological Remodelling of the Brain’s Reward Circuitry: Implications for Addiction
Addictive disorders are chronic, relapsing conditions marked by compulsive drug-seeking and loss of control despite adverse consequences. Growing evidence indicates that addiction is a disorder of maladaptive neuroplasticity—where repeated drug exposure reshapes the brain’s reward, motivation, and…
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Phenotypic and Molecular Characterization of Clinical Staphylococcus aureus: High Burden of MRSA with the Emergence of VISA
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus (VISA and VRSA, respectively) constitute significant global public-health threats due to increasing antimicrobial resistance and limited treatment options. This study aimed…
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MiRNAs and COVID-19: A tale from the beginning to future prospects
During SARS-CoV-2 infection, microRNAs (miRNAs), which are small, evolutionarily conserved non-coding RNAs of 19–24 nucleotides, play a key role in the host-virus interface as post-transcriptional regulators of gene expression. Both host-derived and virus-encoded miRNAs affect infection…
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Curcumin’s Differential Efficacy Against Specific Chemo Agents in Chemotherapy-Induced Peripheral Neuropathy: A Narrative Review
Chemotherapy-induced peripheral neuropathy (CIPN) represents one of the most challenging dose-limiting toxicities in oncology, affecting 20-85% of patients receiving neurotoxic chemotherapy agents. This debilitating condition significantly impacts quality of life and often necessitates dose…
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Impact of IL-10 and TLR-3 Gene Polymorphisms on Hepatitis C Virus Susceptibility and Treatment Outcomes: A Systematic Review and Meta-Analysis
Background: Interleukin-10 (IL-10) and Toll-like receptor-3 (TLR-3) have been linked to differing levels of susceptibility to hepatitis C virus (HCV) infection and associated antiviral treatment response. This systematic review and meta-analysis were to test the association of IL-10 and TLR-3 gene…
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Prospective potential of Incretin-based therapy in managing radiation toxicity: Current evidence and mechanistic insights
Radiation therapy, a crucial tool in cancer treatment, delivers precise cytotoxic effects specifically against malignant cells. Despite its therapeutic efficacy, radiation exposure commonly inflicts collateral damage on surrounding healthy tissues. This damage is largely mediated by persistent…
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The protective effect of simvastatin and rousvastatin in experimentally – induced gastric ulcer in rats: Insights on HPA axis
Peptic ulcer remains a common gastrointestinal condition caused by various physical and psychological stress agents. Even with available treatments, handling stress-induced gastric ulceration continues to cause significant clinical difficulties due to restricted effectiveness and associated side…
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Multiple aspects of pathogenesis of non-alcoholic fatty liver disease and possible treatments
Nonalcoholic fatty liver disease (NAFLD) is an urgent health concern affecting a wide range of population. The increasing prevalence of NAFLD is attributed to the elevated rate of obesity and diabetes. It is characterized by accumulation of lipids in hepatocytes namely steatosis which may be…
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The Evolving World of Antiviral Medications
Viruses are major pathogenic agents responsible for a wide spectrum of pathological conditions in humans, animals, and plants, ranging from self-limiting illnesses to severe, life-threatening conditions. Viral infections continue to represent a worldwide threat and societal crisis, driving ongoing…
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Spanning a quarter century: Tales of three inspiring Nobel prizes that enriched the drug delivery field
Nobel prizes are usually awarded to major breakthroughs in basic science and are usually inspiring to the researchers world-wide to build new ideas and develop others based on them. This can lead to consecutive breakthroughs in applied sciences through all the fields including the medical field and…
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Probiotics in the Management of Esophageal Cancer: A Comprehensive Review of Therapeutic Potential and Supportive Clinical Effects
Background: Esophageal cancer (EC) remains a highly aggressive malignancy with poor prognosis, largely due to the toxicity of multimodal treatments and postoperative complications. Probiotics have emerged as potential adjuncts in cancer therapy, offering both direct anticancer properties and…
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Alpha Lipoic Acid as a Potential Radioprotective Agent against Radiation-Induced Oral Mucositis through its antioxidant and anti-inflammatory effects
Purpose: The main aim of this review is to investigate the potential role of alpha-lipoic acid (ALA), which is a naturally occurring antioxidant in the prevention and management of radiation-induced oral mucositis (RIOM) in head and neck cancer patients undergoing radiotherapy sessions. It…
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Artificial Intelligence in Drug Formulation and Delivery: Benefits, Trends, and Future Perspectives
Computational optimization and its integration with AI in formulation optimization, predictive modeling, and drug-excipient interactions have significantly reduced the conventional trial-and-error approaches. This editorial highlights the integration of artificial intelligence (AI) in optimization…
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The Protective Role of Statins against 5-Fluorouracil-induced Oral Mucositis in Colorectal Cancer Patients-Narrative Review
Oral mucositis (OM) is one of the most frequent complications affecting colorectal cancer (CRC) patients receiving 5-fluorouracil (5-FU). According to recent studies, the release of inflammatory cytokines like tumor necrosis factor-alpha (TNF-alpha) and the generation of reactive oxygen species…
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The Impact of Genetic Polymorphisms on Cisplatin-Induced Acute Kidney Injury: A Systematic Review
Cisplatin is a widely used chemotherapeutic agent effective against various solid tumors, including testicular, ovarian, lung, and bladder cancers. However, its clinical use is often limited by dose-dependent toxicities, with nephrotoxicity being the most concerning side effect. Patients undergoing…
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The effect of N-acetylcysteine on metabolic dysfunction associated with fatty liver disease and polycystic ovary syndrome as metabolic disorders
Metabolic dysfunction associated with fatty liver disease (MAFLD) and polycystic ovary syndrome (PCOS) are common disorders often related to metabolic syndrome. Insulin resistance, obesity, and oxidative stress contribute to the pathogenesis of both MAFLD and PCOS. N-acetyl cysteine (NAC) is an…
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Whey protein: a contemporary gadget for nutraceuticals delivery
Nutraceuticals (NC) often face challenges concerning their stability and bioavailability, limiting their health benefits. Nano-delivery systems (NDS) offer a promising solution by enhancing the protection, stability, and bioavailability of these compounds. Food-grade materials such as whey proteins…
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Ginkgo biloba: A review of its phytoconstituents and pharmacological activities
Ginkgo biloba L. is one of the world's most famous medicinal herbs; it has been used for centuries for treating many diseases. This review article aims to provide an updated overview of the reported active constituents in Ginkgo biloba and its biological activities. G. biloba has existed for 2,000…