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Research in Oncology
ISSN 2357-0687 · Kasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine · 100 articles in the index
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Reactive Lymphadenopathy During Tyrosine Kinase Inhibitor Therapy for Chronic Myeloid Leukemia: Two Case Reports
Background: Tyrosine kinase inhibitors (TKIs) are the cornerstone of chronic myeloid leukemia (CML) therapy. Although generally well tolerated, they may have adverse effects that warrant attention and are rarely documented such as lymphadenopathy mimicking disease progression and prompting…
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Real World Data of Everolimus Combined with Aromatase Inhibitors in Metastatic Breast Cancer: A Cohort of Everyday Clinical Practice Patients in Egypt
Background: In hormone receptor–positive (HR+)/HER2-negative (luminal) metastatic breast cancer (MBC), endocrine therapy (ET) combined with cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are the standard first-line treatment in the absence of visceral crisis. However, resistance to this regimen…
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Utilization and Efficacy of Shorter Palliative Radiotherapy Courses During the COVID-19 Pandemic: A Single Institution Experience
Background: The COVID-19 pandemic significantly affected oncology practice, including the delivery of palliative radiotherapy. Short-course palliative radiotherapy schedules (
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Assessment of Fatigue in Patients with Chronic Myeloid Leukemia Receiving Targeted Therapy: A Cross-Sectional Study
Background: Fatigue is a common side effect of tyrosine kinase inhibitor (TKI) therapy in patients with chronic myeloid leukemia (CML), leading to reduced health-related quality of life (HRQoL) and decreased treatment adherence. Aim: To evaluate the severity of fatigue and the factors influencing…
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Immuno-reactivity of Engrailed (EN)-2 in Epithelial Ovarian Neoplasms
Background: Ovarian neoplasm refers to any tumor that originates primarily in the ovary. Epithelial ovarian neoplasms are the most common type of ovarian tumor and are classified based on their histogenetic and immunophenotypic features. However, treatment modalities based on this classification…
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Salivary Function and Quality of Life Following Adaptive Intensity-Modulated Radiotherapy for Locally Advanced Head and Neck Cancer
Background: Intensity-modulated radiotherapy (IMRT) is the standard treatment for locally advanced head and neck cancer (LAHNC). However, the potential role of adaptive radiotherapy in preserving salivary function and enhancing quality of life (QoL) remains underexplored. Aim: This study aimed to…
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The Outcome of Patients with Cerebral Arteriovenous Malformations (AVMs) Treated with Stereotactic Radiosurgery (SRS) Using the CyberKnife (Rationale, Benefits and Risks): A Real-World Experience
Background: Cerebral arteriovenous malformations (AVMs) are complex, heterogeneous, uncommon lesions that carry a high risk of intracranial hemorrhage with subsequent disability. Aim: To evaluate the outcome of patients with cerebral AVMs treated in our center, King Faisal Specialized Hospital and…
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Is Volumetric Modulated Arc Radiotherapy a Good Choice in the Treatment of Early Glottic Cancer: A Dosimetric Study
Background: The extended survival of patients with early glottic cancer has heightened concerns about the long-term side effects of radiation therapy, which may negatively impact quality of life and increase the risk of non-malignant mortality. This study evaluated whether volumetric modulated arc…
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Silent Metastatic Mucinous Colonic Carcinoma to the Uterine Cervix: A Case Report
Introduction: Metastasis of colon cancer to the uterine cervix is a rare occurrence, with only a few case reports and small series documented in the literature. Case Presentation: We present a case of a patient with asymptomatic metastatic mucinous carcinoma of colonic origin to the cervix. The…
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PD-L1 Expression in Colorectal Cancer and Its Relation to Microsatellite Instability and Cytotoxic Tumor-Infiltrating Lymphocytes
Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Tumor cell PD-L1 expression has been shown to enable immune evasion by suppressing the immune system's active T-cell-mediated response. Aim: To investigate the expression of PD-L1 in CRC and its correlation with…
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Comparison of Touch Imprint Cytology and Frozen Section for Evaluating Sentinel Lymph Nodes in Breast Cancer: A Study from a Tertiary Oncology Center in Upper Egypt
Background: Sentinel lymph node (SLN) biopsy is the preferred method for diagnosing axillary nodal involvement in breast cancer. Touch imprint cytology (TIC) and frozen section (FS) are two intraoperative techniques used to assess SLNs. Both methods have their disadvantages, and the superior…
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No PL in APL: No Perception of Light in Acute Promyelocytic leukemia
Background: Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia with a favorable prognosis. Hemorrhagic manifestations in APL at presentation are usually due to thrombocytopenia, consumptive coagulopathy, and fibrinolysis. Central nervous system (CNS) hemorrhage…
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The Influence of Serum Leptin Level and Body Mass Index on the Prognosis of Patients with Diffuse Large B Cell Lymphoma
Background: More research is ongoing on obesity as a risk factor for cancer occurrence.Cell of origin (COO), stage and National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI) are frequently used for risk evaluation and treatment tailoring in patients with Diffuse large…
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Clinical Trials on Colorectal Cancer in South Africa
Background: Colorectal cancer (CRC) is amongst the most important cancers in resource-constrained South Africa. It is crucial that setting-specific research be conducted which seeks to answer questions around the feasibility of emerging treatment modalities for CRC in South Africa, as well as the…
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Multicentric vs. Unresectable Unicentric Castleman Disease with Active Presentation: An Orphan Rare Disease in a Young Egyptian Female Patient. A Case Report
Background: Castleman disease (CD) is a rare disorder that affects lymph nodes and has a wide range of associated symptoms. The affected lymph nodes show characteristic histological picture. Most of the unicentric Castleman disease (UCD) cases can be cured by complete surgical removal or…
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Evaluation of Immunohistochemical Expression of Human Epidermal Growth Factor Receptor 2 (HER2) and its Association with Clinicopathological Variables in Patients with Pancreatic Duct Adenocarcinoma in Upper Egypt
Background: Pancreatic duct adenocarcinoma (PDAC) is an aggressive neoplasm. It shows progressive and cumulative genetic mutations, with subsequent development of therapy-resistant clones. Human epidermal growth factor receptor 2 (HER2) is a transmembrane glycoprotein that is normally involved in…
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The Impact of Trastuzumab Administration Patterns on the Long-Term Clinical Outcomes of Patients with Non-Metastatic Breast Cancer in a Resource-Limited Setting
Background: Administration of trastuzumab (TRA) in resource-limited settings (RLS) is associated with significant deviations from per-label recommendations such as fixed-dose instead of weight-based, interruptions, and a reduced number of cycles. The impact of these deviations on the clinical…
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Chordoid Meningioma with Extensive Lymphocytic Infiltration Forming Lymphoid Follicles: A Case Report
Background: Meningiomas, the most common primary central nervous system (CNS) tumors, include 15 distinct subtypes reflecting its broad morphological spectrum. Most subtypes have a benign clinical course and correspond to CNS World Health Organization (WHO) grade I. Chordoid meningiomas are a rare…
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Placental Mesenchymal Dysplasia: A Confusing Entity and the Definitive Role of Histopathology
Background: Placental mesenchymal dysplasia (PMD) is a rare placental disease of poorly understood etiology. It is characterized by aneurysmal dilatation of the chorionic blood vessels, mesenchymal proliferation, and myxomatous degeneration of the stem villi. Although it shares radiological and…
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A Diagnostic Dilemma of Encephalopathy in Acute Myeloid Leukemia Patient with Twice COVID-19 Infection: A Case Report
Background: During the COVID‐19 pandemic, there was limited data about the appropriate management of acute myeloid leukemia (AML) with COVID-19 infection and the possible post-COVID-19 complications reported in acute leukemia patients. Case presentation: We report a 52-year-old lady with AML and…