240 results
Showing 1–20 · 1.09 seconds · RSS
Pulmonary Therapy
Scopus
ISSN 2364-1754 · Adis, Springer Healthcare · 240 articles in the index
-
Journal Article
Small Airways Disease Adversely Impacts the Response to Biologic Therapies in Severe Asthma
Abstract Introduction Small airways disease (SAD) is increasingly recognized as a relevant trait in severe asthma, but its influence on outcomes with biologic therapies remains uncertain. We assessed the prevalence of SAD and its association with real-world treatment response in a severe asthma…
-
Journal Article
Clinical Outcomes in Concurrent Cohorts of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA)-Treated versus ELX/TEZ/IVA-Ineligible Individuals with Cystic Fibrosis in the US during COVID-19
Abstract Introduction The initial US launch of elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) coincided with the coronavirus disease 2019 (COVID-19) pandemic, altering healthcare-seeking behaviors and possibly resulting in decreased respiratory infection transmission. We evaluated real-world…
-
Journal Article
Assessment of Clinical Questionnaires for Predicting Obstructive Sleep Apnea in Patients with Non-Valvular Atrial Fibrillation
Abstract Introduction Obstructive sleep apnea (OSA) is common but frequently underdiagnosed in patients with atrial fibrillation (AF), particularly in low- and middle-income countries, where access to polysomnography is limited. This study evaluated the diagnostic accuracy of the STOP-BANG, Berlin…
-
Journal Article
Peripheral Blood Inflammatory Markers and Immune Cell Profiles in Smokers With and Without COPD
Abstract Introduction Cigarette smoking is a major driver of airway and systemic inflammation and contributes to the development and progression of chronic obstructive pulmonary disease (COPD). This study compared peripheral blood inflammatory markers and immune cell profiles in smokers with and…
-
Journal Article
Long-Term Adherence to Elexacaftor/Tezacaftor/Ivacaftor in People with Cystic Fibrosis
Abstract Introduction Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulators are the cornerstone treatment for CF, but nonadherence can reduce their effect. Long-term adherence data on elexacaftor/tezacaftor/ivacaftor (ETI) combined with the evening dose ivacaftor (IVA) are…
-
Journal Article
The Impact of BMI on the Effect of Biologic Agents for Severe Asthma
Abstract Introduction The association between severe asthma and obesity is well established, as higher body mass index (BMI) is associated with higher prevalence and incidence of severe asthma. Biologic agents have been recently developed for severe asthma treatment. However, the efficacy of…
-
Journal Article
2025 Annual Review of Pulmonary Arterial Hypertension Clinical Research
Abstract Introduction Pulmonary arterial hypertension (PAH) remains a progressive and life-threatening disease despite major therapeutic advances over the past three decades. Alongside evolving treatment strategies, the growing complexity of PAH management has been accompanied by an expansion of…
-
Journal Article
Potential Public Health Impact of Updated COVID-19 Vaccination Strategies in Thailand: Epidemiological Data Update
Abstract Introduction This study evaluates the anticipated health and economic effects of multiple COVID-19 vaccination strategies using an updated vaccine in Thailand. Methods A previously published hybrid decision tree and Markov model, originally developed for the USA, was calibrated using…
-
Journal Article
Practical Considerations for Managing Transitions from Parenteral Prostacyclins to Oral Selexipag in Pulmonary Arterial Hypertension
Abstract The prostacyclin pathway represents a foundational pathway in the treatment of patients with pulmonary arterial hypertension (PAH). Parenteral prostacyclin pathway agents (PPAs) are often used for treatment of severe PAH but their broader use is limited by administration difficulties…
-
Journal Article
Impact of Single-Inhaler Triple Therapy FF/UMEC/VI on Disease Stability in COPD: A Real-World 12-Month Analysis
Abstract Introduction Single-inhaler triple therapy with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) is recommended for patients with chronic obstructive pulmonary disease (COPD) who remain symptomatic or experience exacerbations despite dual bronchodilation. However, real-world…
-
Journal Article
Climate Change and the Switch from Pressurised Metered-Dose Inhalers to Dry Powder Inhalers: A Proportionate Balancing of Risk and Reward?
Abstract Urgent action is required to limit the increase in global temperatures. While mitigation efforts are primarily directed at transitioning away from fossil fuels, given their overwhelming contribution to greenhouse gas emissions, infrastructural change is slow to effect. Thus, behavioural…
-
Journal Article
Oscillating Positive Expiratory Pressure (OPEP) Therapy in Bronchiectasis and Chronic Obstructive Pulmonary Disease (COPD): A Narrative Review of Clinical Studies
Abstract Exacerbations associated with bronchiectasis with or without chronic obstructive pulmonary disease (COPD) are often associated with generation and accumulation of excessive mucus in the airways of the lungs. Not only can mucus plugs reduce the perfusion of oxygen to the alveolar gas…
-
Journal Article
Estimation of Public Health Impact with Use of Nirsevimab During the 2024–2025 RSV Season in the USA: a Modeling Study
Abstract Introduction Respiratory syncytial virus (RSV) is a leading cause of medically attended lower respiratory tract disease (MA-LRTD) and hospitalization among infants in the USA. With the introduction in 2023 of nirsevimab, a long-acting monoclonal antibody for infant RSV prevention, early…
-
Journal Article
Real-World Outcomes across Baseline Risk Profiles in Patients with COPD Initiating Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate in Spain: Insights from the ORESTES Study
Abstract Introduction Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder characterized by persistent symptoms such as dyspnea and cough, as well as exacerbations. Triple therapy with budesonide/glycopyrronium/formoterol fumarate dihydrate (BGF) is recommended for patients…
-
Journal Article
Patient Characteristics and Healthcare Resource Use among Patients With COVID-19 Receiving Treatment with Nirmatrelvir/Ritonavir (PAXLOVID™) in the Kingdom of Saudi Arabia
Abstract Introduction Real-world evidence for the use of nirmatrelvir/ritonavir in routine clinical practice remains limited in the Kingdom of Saudi Arabia (KSA). This study aimed to describe the demographic and clinical characteristics, treatment patterns, and healthcare resource utilization…
-
Journal Article
Interrelationship between Daytime Functional Outcomes and Psychological Distress in Patients with Obstructive Sleep Apnea: A Cross-Sectional Study
Abstract Introduction Obstructive sleep apnea (OSA) is associated with decreased daytime functional outcomes and increased psychological stress. However, the specific profile of this burden, particularly in the Vietnamese population, remains understudied. This study aimed to analyze sleep-related…
-
Journal Article
Efficacy and Safety of Brensocatib in Participants of Asian Race with Non-cystic Fibrosis Bronchiectasis: A Subgroup Analysis of the ASPEN Trial
Abstract Introduction In the ASPEN trial, brensocatib, a dipeptidyl peptidase 1 inhibitor, significantly reduced the burden of pulmonary exacerbations versus placebo in participants with bronchiectasis. A prespecified subgroup analysis evaluated the efficacy and safety of brensocatib in…
-
Journal Article
Sarcoidosis: A Clinical Trials Perspective
Abstract Sarcoidosis is a systemic granulomatous disorder of unclear origin, most commonly impacting the lungs and mediastinal lymph nodes. Respiratory manifestations occur in most patients and are the main contributors to disease-related morbidity and mortality. Despite decades of clinical…
-
Journal Article
Interstitial Lung Disease Induced by Monoclonal Antibodies for Psoriatic Arthritis, a Double Hit: A Case Report with a Literature and Clinical Trial Review
Abstract Introduction Monoclonal antibodies (mAb) play a central role in modern medicine; however, several of them have been associated with the development of drug-induced interstitial lung diseases (ILD). We present a case of a patient affected by psoriatic arthritis (PsA) treated with…
-
Journal Article
Estimating the Underreporting of COVID-19 Burden in Selected Countries in Asia, Africa, the Middle East, and Latin America in the Post-pandemic Era
Abstract Introduction The true number of coronavirus disease-19 (COVID-19) cases may be highly underestimated because of reduced efforts to track cases through testing in the postpandemic era. Earlier estimates of this underreporting have varied across regions, and countries in Asia, Africa, the…