464 results
Showing 1–20 · 0.55 seconds · RSS
EJNMMI Radiopharmacy and Chemistry
Scopus
ISSN 2365-421X · SpringerOpen · 464 articles in the index
-
Journal Article
Quality control of actinium-225 and 225Ac-radiopharmaceuticals: Francium-221 to be or not to be?
Abstract Background Actinium-225 radiopharmaceuticals have drawn great interest in cancer therapy due to their tumor-specific delivery of cytotoxic alpha-particles. Quality control (QC) is critical for these potent agents and there is currently no consensus for best practice of actinium-225 QC…
-
Journal Article
Liquid chromatographic determination of enantiomeric purity of [11C]methyl-L-methionine and O-(2-[18F]fluoroethyl)-L-tyrosine by pre-column derivatization with o-phthaldialdehyde and N-isobutyryl-L-cysteine
Abstract Background [11C]methyl-L-methionine ([11C]MET) and O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) are commonly used radiopharmaceuticals in positron emission tomography (PET) for diagnosis of brain tumors. The preparations can be released for human use after the determination of several…
-
Journal Article
Fluorine-18-labeled PET radiotracers for imaging the macrophage colony-stimulating factor 1 receptor (CSF1R)
Abstract Background Positron emission tomography is a useful tool for quantitative imaging of neuroinflammation in human subjects; however, more suitable radiotracers are sought. One of the promising targets for imaging neuroinflammation is macrophage colony-stimulating factor 1 receptor (CSF1R)…
-
Journal Article
191Pt-labeled trithiol-Hoechst-PSMA: preliminary evaluation of conjugates designed for delivery to genomic DNA of PSMA-positive cancers
Abstract Background Several platinum radionuclides, including 191Pt, are promising candidates for DNA-targeted Auger electron radiotherapy; however, effective compound designs are needed for this application. In this study, we developed six novel 191Pt-labeled compounds and evaluated their…
-
Journal Article
A comparative assessment of radiochemical purity and yield of [18F]PSMA-1007 production using two different automated synthesis platforms: a head-to-head comparison
Abstract Background Glutamate carboxypeptidase II (GCPII), also known as prostate-specific membrane antigen (PSMA) is overexpressed in 90–100% of prostate cancer cells. The radiopharmaceutical [18F]PSMA-1007, recognised as a PET tracer for prostate cancer imaging, is based on PSMA inhibitor…
-
Journal Article
Methods for assessing binding of a small-molecule radioligand to soluble enzyme isocitrate dehydrogenase 1 variants
Abstract Background Isocitrate dehydrogenase 1 (IDH1) is a cytosolic NADP+-dependent enzyme involved in cellular redox homeostasis and 2-oxoglutarate (2-OG) metabolism. Glioma-associated mutations in IDH1 confer a neomorphic enzymatic activity, resulting in the production and accumulation of the…
-
Journal Article
Fully GMP-complient radiosynthesis of [161Tb]Tb-PSMA-1 using the miniAiO synthesizer for clinical translation
Abstract Background Terbium‑161 (161Tb) is an emerging radionuclide for targeted radionuclide therapy that combines β⁻ emissions with short‑range conversion and Auger electrons, increasing its efficacy against micrometastatic and low‑volume prostate cancer. This study aimed to develop, optimize…
-
Journal Article
Optimization, automation and validation of NOP receptor PET radiopharmaceutical, [11C]NOP-1A for human use
Abstract Background In vivo human studies of the nociceptin/orphanin FQ peptide (NOP) receptor have been limited by the availability and reliable production of suitable PET radioligands. [11C]NOP-1A is a high-affinity PET radioligand for imaging NOP receptors; however, reproducible production…
-
Journal Article
Energy dependent production and radionuclidic purity of $$\:{\:}^{47}\mathbf{S}\mathbf{c}\:$$ from $$\:{\:}^{48}\mathbf{C}\mathbf{a}(\varvec{p},\varvec{x}\varvec{n})\:$$ reactions: a combined theoretical and data from EXFOR library using the EMPIRE code
Abstract Background The production of Scandium-47, a promising radionuclide for targeted radionuclide therapy, was investigated via proton-induced reactions on enriched Ca-48 using the EMPIRE nuclear reaction code. A comparative analysis between EMPIRE simulations and experimental data extracted…
-
Journal Article
Optimization of [18F]FBPA production for clinical translation through precursor development and manufacturing route evaluation
Abstract Background 4-Borono-2-[18F]fluorophenylalanine ([18F]FBPA) is an important imaging agent for identifying suitable candidates for boron neutron capture therapy (BNCT). This study aimed to develop three new precursors for the no-carrier-added synthesis of [18F]FBPA and to establish…
-
Journal Article
Recycling-compatible electroplating of enriched tin-119 targets for the production of antimony-119 for targeted Auger electron therapy
Abstract Background Antimony-119 (119Sb) is a radionuclide of interest for targeted Auger electron therapy. Isotopically pure 119Sb can be produced by proton irradiation of enriched tin-119 (119Sn) targets in conventional widely available low energy medical cyclotrons. Enriched 119Sn is very costly…
-
Journal Article
Radionuclide-based pharmaceuticals for breast cancer imaging: state of the art
Abstract Background Breast cancer (BC) is a biologically heterogeneous disease, and no single imaging modality captures the full spectrum of phenotypes across all stages of the disease. This review summarizes advances in receptor-targeted nuclear imaging approaches that support patient…
-
Journal Article
Optimization of automated radiosynthesis method for [18F]AlF-NOTA-Octreotide and PET/CT imaging in neuroendocrine neoplasms
Abstract Background Neuroendocrine neoplasms (NENs) represent heterogeneous tumors with increasing occurrence rate. Somatostatin receptor (SSTR) imaging using 68Ga-labeled analogs is crucial but limited by the relatively short half-life of this radionuclide along with its reliance on generator…
-
Journal Article
A 3D co-culture model with fibroblast-restricted FAP expression for cancer therapy using [212Pb]Pb-FAPI-46
Abstract Background Targeting components of the tumor microenvironment has become a pan-cancer treatment strategy. Fibroblast activation protein (FAP)-targeted radioligand therapy exploits FAP expression in cancer-associated fibroblasts (CAFs) within the tumor stroma. However, several preclinical…
-
Journal Article
Radiation stability and performance of TEHDGA resin for theranostic scandium radionuclide purification
Abstract Background Scandium radionuclides are emerging theranostic radionuclides that offer matched diagnostic and therapeutic emissions for targeted applications in nuclear medicine. For their safe and effective clinical use, it is crucial to obtain preparations with very high radiochemical…
-
Journal Article
Panitumumab labeled with Auger electron-emitting 197gHg/197mHg: cytotoxicity on human breast cancer cells and tumour and normal tissue uptake in mice with EGFR-overexpressing breast cancer xenografts
Abstract Background 197gHg and 197mHg are attractive radionuclides for radioimmunotherapy of cancer due to their abundant Auger electron emissions (23.2 and 19.4 electrons/decay, respectively). Our aim was to study the cytotoxicity and DNA-damaging properties of panitumumab labeled with…
-
Journal Article
Automated and manual synthesis of [68Ga]Ga-DOTA-4AH29 intended for PET-imaging of FAP-expression
Abstract Background Fibroblast activation protein is a well-established target for tumour imaging, and single-domain antibodies (sdAb) offer favourable pharmacokinetic properties for PET applications. However, the translation of sdAb-based radiotracers into robust and clinically applicable…
-
Journal Article
The influence of functional groups and their relative position on isotopic exchange between 19F and 18F in aromatic rings
Abstract Background Isotopic exchange with fluorine-18 offers a conceptually simple approach to positron emission tomography (PET) tracer development, as the target compound itself serves as the labeling precursor. Results In this study, we investigated the influence of functional groups and…
-
Journal Article
Development and preclinical evaluation of selective vinyl sulfone-based probes for PET imaging of tumor-associated cathepsins
Abstract Background Cysteine cathepsin L (CatL) is emerging as a key biomarker of cancer progression, making it an attractive candidate for non-invasive molecular imaging. To monitor enzymatic activity directly, rather than merely protein expression, activity-based probes (ABPs) enable selective…
-
Journal Article
Scaling the production of bromine-76 and bromine-77 labeled poly-ADP-ribose-polymerase-targeted theranostics for preclinical use
Abstract Background Bromine-76, a positron emitting radionuclide for positron emission tomography (PET) imaging, and bromine-77, an Auger electron (Ae) emitting radionuclide, make a unique halogen theranostic pair. These isotopes have previously been used to synthesize a rucaparib-derived…