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AIMS Molecular Science
ISSN 2372-0301 · AIMS Press · 213 artikel di indeks
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Artikel Jurnal
Altered plasma levels of arachidonic acid, choline, amino acids, and sphingolipids signal neural tube defects
Neural tube defects (NTDs) are common congenital anomalies formed by the incomplete closure of the neural tube during early embryonic development. This study aims to identify potential plasma biomarkers associated with NTDs using an untargeted metabolomics approach, thereby enhancing the…
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Artikel Jurnal
Identification of phosphoinositide-associated microRNAs reveals candidates with potential roles in cancer signaling
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression and have been associated with pathological processes, including oncogenesis. In this study, the interaction between miRNAs and phosphoinositides, particularly phosphatidylinositol 4,5-bisphosphate (PIP2), was explored by…
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The other way around: Using eco-cyanomolecules for human welfare
Cyanobacteria constitute a group of photooxybacteria. It is difficult to provide an estimate of their diversity due to the ongoing debate on the usefulness of various species concepts and methodologies used to delineate them. They occupy, thrive, and proliferate in diverse habitats, exhibiting…
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Diabetic cardiomyopathy: Role of the cardiac mitochondrial melatonergic pathway
Although cardiovascular diseases, especially diabetic cardiomyopathy (DCM), account for up to 80% of deaths in diabetic patients, the pathophysiological changes driven by diabetes on cardiovascular function are poorly defined and treated. As with many medical conditions, increased levels of Nuclear…
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Artikel Jurnal
Identification of auxin response factor in the pan-genome and their expression pattern analysis in cucumber
Auxin response factors (ARFs) are important transcription factors that regulate the expression of early genes in response to auxin. Auxin is a crucial phytohormone that controls plant growth and development. Even though ARF genes have been identified in the cucumber (Cucumis sativus) genome version…
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Artikel Jurnal
Nanomedicine in cancer diagnosis and therapeutics
Cancer has emerged as a significant global health challenge, with both its occurrence and death toll rising annually. Studies have shown that early, precise diagnosis and targeted cancer therapy can effectively reduce the mortality rate of malignant tumors. As an emerging field, nanomedicine seeks…
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Cationic nanocapsules as a non-viral vector for CRISPR-Cas9–based genome editing for myocilin associated glaucoma therapy
Our aim of this work was the development of positively charged D-α-tocopheryl glycol succinate 1000 (TPGS)-chitosan nanocapsules (TCNs) as a non-viral vector for effective genome editing. A two-step process was used to create cationic TCNs. TPGS was initially esterified using succinic anhydride to…
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Artikel Jurnal
Combinatorial application of artificial intelligence and CRISPR/Cas9 on the next-generation CAR-T immunotherapy
Chimeric Antigen Receptor T-cell (CAR-T) therapy has emerged as one effective treatment against complex diseases, including malignancies, infectious disorders, and autoimmune conditions. However, its clinical applications remain hindered by severe side effects, including cytokine release syndrome…
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Neuroinflammation in neurodegenerative disorders: Activation of microglia by microbial infection
Neurodegenerative disorders present a significant global health challenge. Neuroinflammation, which is a frequent occurrence of these diseases, may serve as an initial trigger. Emerging evidence suggests that microglia play a pivotal role as mediators of inflammation in the central nervous system…
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Antimicrobial activity of Ziziphus mauritiana and Acacia nilotica against multidrug-resistant Escherichia coli and Klebsiella pneumoniae
Multidrug-resistant (MDR) strains such as Escherichia coli and Klebsiella pneumoniae, resistant to broad-spectrum antibiotics, are a modern global issue. Plant extracts offer promising antimicrobial activity for such pathogens. This study evaluated the efficacy of aqueous and hydro-ethanolic…
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Artikel Jurnal
Ecological screening and functional analysis of pigments, antioxidants and potent sunscreen compounds in cyanobacteria inhabiting diverse habitats
Cyanobacteria are incredibly versatile and morphologically the most diverse prokaryotic organisms across the globe. Cyanobacteria are capable of synthesizing their own protective metabolites in any harsh environmental condition. Moreover, anthropogenic-induced depletion of the ozone layer has…
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Comparative effects of conventional and modern drying methods on drying time, energy consumption, and physicochemical properties of lavender (Lavandula stricta Del.)
Lavender is known as a natural antidepressant and sleep-promoting herbal medicine. In this study, we compared six distinct drying techniques: Refractance window drying (RW), freeze drying (FD), microwave drying (MW), infrared drying (IR), hot air drying (HA), and shade drying (SD), to evaluate…
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Network pharmacology study to identify molecular pathways involved in the anti-diabetic activity of Syzygium cumini seed constituents
Diabetes is characterized by hyperglycemia and insulin resistance, which significantly increase the risk of morbidity and mortality. Syzygium cumini seeds have been used traditionally in the management of diabetes, though the precise molecular mechanisms underlying their effects are not yet fully…
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Pharmacological and therapeutic inventory of fungi in cancertherapy—A comprehensive review
Cancer remains one of the foremost causes of death worldwide. Despite advancements in pharmaceutical therapies, patients continue to experience adverse effects. Consequently, there is a considerable interest in exploring mushrooms as a supplemental cancer treatment. In Asian countries, edible and…
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Radical scavenging capacity of RuBisCO bioactive peptides derived from Dunaliella salina and Spirulina platensis: An in silico and in vitro study
Microalgae have a large high-quality protein content that can be used as human protein supplements. Dunaliella salina and Spirulina platensis have been identified as rich sources of natural bioactive compounds. We aimed to examine the antioxidant properties of bioactive peptides using the enzymatic…
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The master energy sensor AMPK-1α regulates the expression of various autophagic and mitochondrial respiratory elements in T cell memory
AMPK-1α is a master energy sensor that phosphorylates more than 100 client proteins involved in almost all branches of cellular metabolism. We recently demonstrated that weak mTORC1 (mTORC1Weak) signaling promotes the differentiation of pro-survival cytokine IL-7- or IL-15-stimulated CD8+ memory T…
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Therapeutic application of curcumin and its nanoformulation in dentistry: Opportunities and challenges
Curcumin (CUR) a natural polyphenolic compound, has attracted significant attention due to its broad-spectrum anti-inflammatory, antioxidant, antimicrobial, and antitumor activities. However, its poor water solubility, low bioavailability, and limited stability have hindered clinical applications…
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Functional evaluation of saclipins A and B derived from the edible cyanobacterium Aphanothece sacrum: New bioactivities for anti-wrinkle and anti-hypertension
Saclipin A and saclipin B are bioactive oxylipin compounds derived from an edible cyanobacterium, Aphanothece sacrum. Saclipins have been shown to have potent anti-aging properties, including antioxidative, antiglycative, anti-wrinkle, and skin-whitening activities. In this study, we demonstrate…
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Gallocatechin analogues from Olax subscorpioidea Oliv. against multiresistant clinical bacterial isolates
The recurrence of bacterial infections is commonly associated with the multiple interactions between humans and their environment. These interactions have progressively contributed to the development of antimicrobial resistance among numerous clinically important pathogenic bacteria. The present…
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Artikel Jurnal
Photobiomodulation with low-level laser (λ = 808nm) to treat experimental rheumatoid arthritis: A morphological study, collagen fiber analysis and IL-6 protein expression
Rheumatoid arthritis is a chronic systemic autoimmune disease that affects the synovial joints. Low-level laser photobiomodulation (LLLT) has microcirculatory, analgesic, and anti-inflammatory effects. In this paper, the percentage of collagen fibrils and IL-6 protein expression in the synovia were…