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Molecular & Cellular Oncology
Scopus
ISSN 2372-3556 · Taylor & Francis Group · 591 artikel di indeks
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Artikel Jurnal
Lactylation-related genes signature panel in hepatocellular carcinoma reveals the prognostic and therapeutic optimization
Lactylation-related genes (LRGs) exert a significant influence on tumor progression and are critically involved in modulating responses to immune checkpoint inhibitors (ICIs). Leveraging a curated set of 332 LRGs derived from the literature, we identified prognosis-specific hepatocellular carcinoma…
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Artikel Jurnal
Mutation detection in women diagnosed with endometrial cancer: a next-generation sequencing analysis
Endometrial cancer (EC) is a heterogeneous gynecological malignancy characterized by diverse genetic and epigenetic alterations. This study investigated genetic mutations associated with EC among Kurdish women using next-generation sequencing (NGS). Seventy histopathologically confirmed EC cases…
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Artikel Jurnal
Evolutionary perspectives on endometrial cancer: antagonistic pleiotropy
The incidence of endometrial cancer is increasing worldwide, with a particularly marked rise in early-onset cases. Modern environmental and lifestyle factors, including low parity, delayed childbirth, obesity, insulin resistance, and chronic inflammation, are thought to contribute to this trend…
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Artikel Jurnal
Integrating single-cell transcriptomics to construct an oncogene-driven prognostic model and elucidate metabolic-immune crosstalk in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, its progression and treatment heterogeneity are mainly influenced by driver gene and tumor micro-environment (TME) interactions. Nevertheless, the mechanisms of this process at the single-cell level remain unclear. This…
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Artikel Jurnal
Enhanced glucose uptake promotes the survival of hepatocellular carcinoma cells following incomplete radiofrequency ablation
Incomplete radiofrequency ablation (iRFA) exposes residual hepatocellular carcinoma (HCC) cells to sublethal thermal stress, which triggers metabolic adaptations that support cell survival. In this study, we demonstrate that iRFA significantly enhances glucose uptake in HCC cells, contributing to…
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Artikel Jurnal
Integrative multi-omics profiling identifies a lactylation-associated, metabolically active, and immunosuppressive subtype of colon adenocarcinoma
Background Histone lactylation, a lactate-derived post-translational modification, bridges metabolic activity and gene regulation. However, its molecular mechanisms and clinical significance in colon adenocarcinoma (COAD) remain poorly characterized.Methods We conducted multi-omics analyses on TCGA…
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Artikel Jurnal
Exploration of the diagnostic and therapeutic potential of the nucleocytoplasmic shuttling protein TMUB1 by inducing G0/G1 cell cycle arrest in ovarian cancer
Background Ovarian cancer is one of the leading causes of gynaecologic malignancies worldwide. This study aimed to explore the diagnostic and therapeutic potential of TMUB1 in ovarian cancer.Methods To investigate the subcellular localization of TMUB1 under serum deprivation conditions…
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Artikel Jurnal
The LNK adaptor protein: a dual regulator of proliferation and migration in solid tumors
Cancer is a significant public health problem. Alterations in critical cellular responses, such as proliferation, survival, and migration, are hallmarks of cancer. Deregulation of the JAK/STAT, MAPK, and PI3K/AKT signaling pathways has been implicated in the development of most solid cancers…
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Artikel Jurnal
mRNA vaccines in oncology: personalized cancer immunization and neoantigen targeting
Precision oncology is evolving with personalized mRNA neoantigen vaccines, although long-term clinical responses vary. These mRNA-based vaccines have facilitated the development of patient-specific neoantigens. Clinical success is dependent not only on immunogenicity but also on tumor neoantigen…
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Artikel Jurnal
SNX1 inhibits human ovarian cancer progression via regulation of the cell cycle, apoptosis and migration
Sorting nexin 1 (SNX1), a member of the sorting nexin family, has been implicated in various cellular processes, yet its role in ovarian cancer (OV) remains poorly characterized. In this study, we systematically investigated the expression pattern, prognostic relevance and functional impact of SNX1…
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Artikel Jurnal
Increased MLH1, MGMT, and p16INK4a methylation levels in colon mucosa potentially useful as early risk marker of colon cancer
The genes MutL Homolog 1 (MLH1), O6-methylguanine-DNA methyltransferase (MGMT), and cyclin-dependent kinase inhibitor p16INK4a are commonly downregulated by hypermethylation in colorectal cancer. Long interspersed nucleotide element 1 (LINE-1) can be used as marker for global hypomethylation. This…
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Artikel Jurnal
GSTP1 knockdown induces metabolic changes affecting energy production and lipid balance in pancreatic cancer cells
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options, underscoring the need for novel therapeutic targets. Metabolic reprogramming is a hallmark of PDAC, enabling tumor cells to sustain rapid proliferation and survive under nutrient-deprived conditions…
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Artikel Jurnal
The Role of V-ATPase ATP6V0D1 Subunit in Chemoresistance and Ellipticine-Induced Cytoplasmic Vacuolation in Neuroblastoma Cells
Drug resistance remains a major obstacle in neuroblastoma treatment. Lysosomal sequestration, facilitated by the V-ATPase proton pump, is one of the mechanisms of chemoresistance. Overexpression of the ATP6V0D1 subunit of V-ATPase, previously reported in various cancers, was also observed in…
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Artikel Jurnal
TRIM22 promotes glioblastoma development by ubiquitinating Bcl-2
Glioblastoma (GBM) exhibits elevated TRIM22 expression correlated with tumor progression, as validated in TCGA/GEO databases. The effects of TRIM22 knockdown and overexpression on GBM proliferation were evaluated with cellular assays. TRIM22 was identified as a potential Bcl-2 activator via a…
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Artikel Jurnal
Loss of Schwann cell’s normal rhythmic core clock gene expression and gain of rhythmic expression of oncogenic driver genes in malignant NF1-associated peripheral nerve sheath tumor
Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor syndrome caused by pathogenic variants in the NF1 gene. Beside tumor formation, patients often have sleep disturbances, suggesting circadian involvement. Previous NF1 studies have implicated MAPK pathway, cAMP-PKA, calcium signaling, and…
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Artikel Jurnal
The immunopeptidome of colon cancer cells treated with topoisomerase inhibiting drug reveals differential as well as common endogenous protein sampling and display of MHC I-associated peptides
Immunotherapy options for microsatellite stable (MSS) colorectal cancer are currently very limited. The lack of detectably unique or altered immunogens in the tumor microenvironment may be a factor. Radiation and chemotherapy may enhance immunotherapy by increasing cancer cell visibility through…
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Artikel Jurnal
CHK1 inhibition overcomes gemcitabine resistance in non-small cell lung cancer cell A549
The purpose of the study is mainly to investigate anti proliferation of non-small cell lung cancer A549 cells and its mechanism by inhibition of CHK1 expression combined with gemcitabine. The mRNA and protein levels of genes were analyzed by RT-qPCR and Western blot, respectively. Cell viability…
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Artikel Jurnal
Single-cell analysis reveals XCL1+ CD8+ T cells as a therapeutic target in hepatocellular carcinoma
XCL1 (lymphotactin), a C-chemokine primarily produced by activated CD8+ T cells, remains poorly characterized in the context of immunotherapy. Here, we conducted comprehensive analyses based on multiple scRNA-seq datasets to identify the presence of XCL1+ CD8+ T cells in hepatocellular carcinoma…
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Artikel Jurnal
Inactivation of Acetyl-CoA Acyltransferase 1 enhances the proliferation and motility of nasopharyngeal carcinoma cells
Acetyl-CoA acyltransferase 1 (ACAA1), encoding the peroxisomal 3-ketoacyl-CoA thiolase (POT1), plays a pivotal role in the fatty acid beta-oxidation pathway. Accumulating evidence has linked this enzyme to the onset and development of diverse human malignancies. Here, we observed a marked…
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Artikel Jurnal
Cytokeratin expression in breast cancer: from mechanisms, progression, diagnosis, and prognosis to therapeutic implications
Background and Aim Cytokeratins (CKs) are structural proteins vital to epithelial integrity and play key roles in breast cancer progression. This review explores their expression, functions, and therapeutic potential.Methods A systematic review was performed using PubMed, Scopus, and Google…