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npj Parkinson's Disease
Scopus
ISSN 2373-8057 · Nature Portfolio · 1,339 articles in the index
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Journal Article
Low-frequency activity in the subthalamic nucleus informs about the acute neuropsychiatric state in Parkinson’s disease
Abstract Sensing-guided deep brain stimulation (DBS) offers potential to further optimize symptom control in Parkinson’s disease (PD) patients. Emerging evidence suggests that basal ganglia signals reflect not only motor, but also chronic neuropsychiatric symptoms. However, it remains unclear…
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Journal Article
Genome-wide association and population-tailored polygenic risk for Parkinson’s disease in Taiwan
Abstract Genetic risk factors for Parkinson’s disease (PD) remain under-characterized in East Asian populations. We assembled a Taiwanese case–control cohort (2245 PD; 2147 controls), genotyped participants using the Illumina NeuroBooster Array, and imputed 7.6 million variants with the Taiwan…
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Journal Article
Micro-nanoplastics and Parkinson’s disease: evidence and perspectives
Abstract With the intensification of global plastic pollution, the potential threats posed by micro- and nanoplastics (MPs/NPs) to human health have become a major concern. MPs/NPs enter the organism through ingestion, inhalation, and skin contact, subsequently accumulating in multiple…
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Journal Article
Clinical utility of evoked potentials for programming subthalamic deep brain stimulation in Parkinsons disease
Abstract Optimal subthalamic nucleus deep-brain stimulation (STN-DBS) for Parkinson’s disease reduces motor symptoms without stimulating adjacent structures and causing side-effects. Fine-tuning STN-DBS using clinical evaluation is time-consuming and often requires multiple follow-ups…
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Journal Article
Moving beyond the hospital: in-depth characterization of daily-life mobility in patients with atypical Parkinsonian disorders
Abstract This study evaluates mobility in patients with multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and Parkinson’s disease (PD) by integrating clinical assessments, instrumented gait analysis (IGA) in the hospital, and 1 week of physical activity monitoring (PAM) at home…
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Journal Article
Evaluation of the neurotrophic peptide mixture in pathogenetic therapy of patients with Parkinson’s disease
Abstract This exploratory, single-group, open-label study investigated 17 patients with Parkinson’s disease (PD) using a pre-post design. Motor and non-motor outcomes were assessed through clinical scales, biochemical and genetic analyses, and machine learning models (Gradient Boosting Machines…
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Journal Article
Metagenomics indicates an interplay of the microbiome and functional pathways in Parkinson’s disease
Abstract Previous studies suggest there are distinct gut microbial and functional variations in patients with Parkinson’s disease (PwPD) that may reveal potential microbiome signatures or biomarkers to aid in early detection of the disease. In this case-control study, we used whole genome…
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Journal Article
Decoding the impact of visual states on adaptive deep brain stimulation feedback signals in movement disorders
Abstract We investigated the impact of visual states on basal ganglia oscillatory biomarkers, comparing local field potentials (LFPs) dynamics between Parkinson’s disease (PD) and dystonia and developing a decoding model for state identification. Simultaneous LFPs recordings from the subthalamic…
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Journal Article
Association between instrumental activities of daily living and incidence of Parkinson’s disease: a nationwide population-based cohort study
Abstract Several studies have investigated the prodromal factors for early diagnosis of Parkinson’s disease (PD). Instrumental activities of daily living (IADL) involve both motor and non-motor functions, and has been used as a screening tool for dementia. This study aimed to examine the…
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Journal Article
Systematic evaluation of mitochondrial morphology regulators for amelioration of neuronal α-synucleinopathy
Abstract Neuronal mitochondria display distinct morphologies across compartments, with dendritic mitochondria being elongated and axonal ones shorter, and their morphologies are dynamically changed via fusion and fission machineries. Mitochondrial structural abnormalities are common in…
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Journal Article
Explainable SHAP- XGBoost with DAT and clinical data for freezing of gait detection in Parkinson disease
Abstract Freezing of gait (FOG) is a common and debilitating symptom in Parkinson’s disease (PD) that requires early detection for timely intervention. In this study, we developed an explainable SHAP-XGBoost model integrating clinical assessments and dopamine transporter (DAT) imaging to identify…
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Journal Article
Imaging spatial transcriptomics reveals molecular patterns underlying accumulation of p-Ser129 α-synuclein in a transgenic mouse model
Abstract In Parkinson’s disease and dementia with Lewy bodies, aggregated and phosphorylated α-synuclein appears in select neurons throughout cortical and subcortical regions, but little is currently known about why certain populations are selectively vulnerable. Here, using imaging spatial…
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Journal Article
Microglial low-affinity FcγR mediates the phagocytic elimination of dopaminergic neurons in Parkinson’s disease degeneration
Abstract It is postulated that microglial cells interact with dopaminergic (DA) neurons of the substantia nigra pars compacta (SNpc), playing a critical role in Parkinson’s disease (PD) neurodegeneration. However, the specific mechanisms by which microglial reactivity is triggered remain unclear…
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Journal Article
Prediction of impulse control disorders in Parkinson’s disease through a longitudinal machine learning study
Abstract Impulse control disorders (ICD) in Parkinson’s disease (PD) patients mainly occur as adverse effects of dopamine replacement therapy. Despite several known risk factors, ICD development cannot yet be accurately predicted at PD diagnosis. We aimed to investigate the predictability of…
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Journal Article
Video-based machine learning models for predicting deep brain stimulation outcomes in Parkinson’s disease patients
Abstract Current levodopa challenge test (LCT) for deep brain stimulation (DBS) candidate screening in Parkinson’s disease (PD) relies on subjective clinical scales, limiting its predictive capacity for postoperative motor outcomes. We developed video-based machine learning models using quantified…
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Journal Article
Parkinson’s disease: spatiotemporal regulation and therapeutic prospects of TREM2-mediated microglial responses
Abstract Parkinson’s disease (PD) presents a challenge, with neuroinflammation and immune dysregulation central to its pathogenesis. This review examines TREM2—a microglial receptor governing phagocytosis, metabolic adaptation, and immune phenotypes—as an important orchestrator of innate immunity…
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Journal Article
Prevalence of low muscle mass and its association with orthostatic hypotension and related symptoms in Parkinson’s disease
Abstract Although muscle mass loss is an emerging public health concern, its prevalence, associated factors, and clinical significance in Parkinson’s disease (PD) remain unclear. This matched case-control study aimed to investigate the prevalence of low muscle mass (LMM) and to examine its…
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Journal Article
Multi-omic insight into the molecular mechanism of cuproptosis-related genes in the pathogenesis of Parkinson’s disease
Abstract Cuproptosis has been linked to Parkinson’s disease (PD), but underlying genetic mechanisms remain unclear. We integrated multi-omic QTL data (methylation, gene expression, protein) with GWAS data of PD (discovery: GWAS Catalog; replication: UK Biobank/FinnGen/IEU). Integrated summary-data…
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