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Transplantation Direct
Scopus
ISSN 2373-8731 · Wolters Kluwer · 1.231 artikel di indeks
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Artikel Jurnal
Differences in Mortality by Donor Sex and Age in a Multinational Cohort of Liver Transplant Recipients
Background. Prior studies assessing the association between donor sex and liver transplant outcomes showed conflicting results. We hypothesized that donor age, recipient sex, and time posttransplant modify the relationship between donor sex and mortality. Methods. First deceased donor liver…
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Artikel Jurnal
Effect of Donor–Recipient Age Difference on Liver Transplant Outcomes
Background. The global organ shortage and aging population lead to the use of liver grafts with increasing donor–recipient age discrepancies. This study evaluated the impact of donor–recipient age mismatch on posttransplant outcomes. Methods. Organ Procurement and Transplantation Network/United…
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Artikel Jurnal
Comparison of Multiple Frailty Scoring Metrics in Renal Transplant Candidates: A Large Single-center Cohort Study
Background. Pretransplant patients are not required to undergo objective frailty testing, although current listing and allocation policies do record functional metrics. Multiple different metrics exist for assessing frailty. Methods. We investigated different frailty metrics in patients presenting…
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Artikel Jurnal
Lower Limit of Normal of Pulmonary Function to Define Baseline Lung Allograft Dysfunction
Background. Subnormal lung function after lung transplantation (LTx) has increasingly been recognized as an independent risk factor for mortality. Historically, baseline lung allograft dysfunction (BLAD) has been defined using the fixed “< 80% predicted” threshold from population-wide reference…
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Artikel Jurnal
Cytomegalovirus-specific CD154-expressing T Cells are Present Before Transplantation in Cytomegalovirus-seronegative Recipients and Predict Early Cytomegalovirus DNAemia
Background. Cytomegalovirus (CMV) antiviral drugs can cause side effects and promote the emergence of drug-resistance after transplantation. T cell–mediated immunity to CMV (CMI) can be used to limit and optimize the duration of antiviral therapy. However, interferon-gamma release assays show…
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Artikel Jurnal
A Whole-body Cooling Strategy in Uncontrolled Donation After Circulatory Death: Insights From a Porcine Ex Vivo Lung Perfusion Model
Background. Prolonged warm ischemia in uncontrolled donation after circulatory death (uDCD) potentially increases the risk of graft dysfunction in lung transplantation. To address this concern, a noninvasive, whole-body cooling approach was developed using a specialized liquid refrigerant at −21…
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Artikel Jurnal
Understanding the Relationship Between Severe Donor Diabetes Insipidus, Kidney Donor Profile Index, and Recipient Kidney Function
Background. Severe diabetes insipidus (DI) causes dynamic changes in creatinine before organ donation. It is unknown whether terminal or peak creatinine is the optimal measure of graft quality among donors with severe DI. Methods. Adult donors after brain death were identified from the United…
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Artikel Jurnal
Growth Trajectories of Medication Adherence in Pediatric Organ Transplantation and Their Relationship to Posttransplant Health Outcomes
Background. Nonadherence to immunosuppressive medication remains one of the most critical predictors of late acute rejection, hospitalization, and graft loss in pediatric organ transplant recipients. Despite its clinical importance, longitudinal patterns of adherence behavior in this population…
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Artikel Jurnal
Consulting r/Transplant: Assessment of Reddit Use and Sentiment in Solid Organ Transplantation
Background. Solid organ transplants are life-changing experiences that impact recipients, donors, care partners, medical teams, communities, and popular media. Social media is an influential part of modern life and provides a platform for healthcare experiences. This study assessed perspectives on…
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Artikel Jurnal
Donor Time to Death and DCD Liver Transplant Outcomes: Challenging the Dogma That Shorter Is Better
Background. In circulatory death transplantation, time to death (TTD) following withdrawal of life-sustaining treatment is unpredictable. Concerns persist that prolonged TTD may cause ischemic injury, resulting in organ nonuse. We assessed the impact of donor TTD on liver transplant outcomes and…
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Artikel Jurnal
Heme Oxygenase-1 as a Predictor of Early Allograft Dysfunction in Liver Transplantation: A Prospective Observational Pilot Study
Background. Early allograft dysfunction (EAD), defined as hepatic insufficiency within a week of orthotopic liver transplantation (OLT), affects up to 25% of recipients and is associated with morbidity and mortality. Ischemia–reperfusion injury (IRI), the primary driver of EAD, reflects immune and…
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Artikel Jurnal
Thirty Years and Beyond: Long-term Outcomes After Liver Transplantation at a Single Center: Progress, Challenges, and Future Implications
Background. The liver transplantation (LT) program was established at Hannover Medical School in 1972. The aim of the study was to assess graft and patient survival, organ function, and active life throughout ≥3 decades after LT, with a special focus on recipients surviving ≥30 y after…
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Artikel Jurnal
Predictors of Early Posttransplant Complications and Clinical Outcomes in Kidney Transplant Recipients Aged ≥65 y
Background. Older adults represent a growing proportion of kidney transplant (KT) recipients, but early posttransplant morbidity remains substantial. We aimed to identify pretransplant factors associated with a complicated early posttransplant course in recipients aged ≥65 y and to assess its…
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Artikel Jurnal
Sex, Drugs, and the Language of Donor Narratives: Associations With Kidney Acceptance
Background. Despite the shortage of donor kidneys, nonutilization remains common. We hypothesized that social history language in donor narratives influences acceptance. Using Natural Language Processing, we evaluated how language describing high-risk behaviors interacts with objective data (eg…
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Artikel Jurnal
Effects of End-ischemic Hypothermic Oxygenated Perfusion on 1-y Graft Function in Kidney Transplantation: A Real-world, Single-center Analysis From the United States
Background. Hypothermic oxygenated perfusion (HOPE) supplies oxygen to kidney allografts for resuscitation before transplantation and may improve graft recovery. This study represents the first U.S.-based comparative analysis evaluating the impact of HOPE on kidney transplant (KT) outcomes…
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Artikel Jurnal
Real-time Quality Assessment of Donor Kidneys During Normothermic Machine Perfusion Using Perfusate and Urinary Biomarkers
Background. Objective, real-time criteria for kidney graft quality during normothermic machine perfusion (NMP) are lacking, contributing to subjective acceptance decisions and organ discard. We evaluated real-time perfusate/urinary biomarkers and perfusion parameters during NMP and developed an…
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Artikel Jurnal
Predictive Value of Perfusate Cell-free DNA During Hypothermic and Normothermic Machine Perfusion of Donor Kidneys
Background. Cell-free DNA (cfDNA) is a potential biomarker for graft (dys)function during machine perfusion, but its ability to predict posttransplant outcomes in donor kidneys remains unclear. Methods. We analyzed perfusate cfDNA from 57 hypothermic machine-perfused (HMP) and 56 normothermic…
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Artikel Jurnal
Comparing Gas and Inhaled Pharmacologic Interventions During Ex Vivo Lung Perfusion: A Systematic Review
Background. Ex vivo lung perfusion (EVLP) has expanded the use of donor lungs by enabling ex vivo assessment, preservation, and rehabilitation before transplantation. Despite these advances, ischemia-reperfusion injury, inflammatory activation, pulmonary edema, and impaired lung mechanics continue…
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