812 hasil
Menampilkan 1–20 · 0,20 detik · RSS
npj Breast Cancer
Scopus
ISSN 2374-4677 · Nature Portfolio · 812 artikel di indeks
-
Artikel Jurnal
Evaluating the clinical utility of ctDNA testing to identify molecular cancer progression – lessons from SERENA-6
Mutation identification via circulating tumor DNA (ctDNA) to select appropriate therapy has demonstrated clinical utility in metastatic breast cancer (MBC). SERENA-6 demonstrated the efficacy and tolerability of camizestrant in HR + /HER2-, ESR-1 mutated MBC after an AI/CDK 4/6 inhibitor. However…
-
Artikel Jurnal
Axillary surgery in patients with sentinel node macrometastases: secondary results of the randomized INSEMA trial
Abstract The sub-study of the INSEMA trial (randomization-2) compares completion axillary lymph node dissection (cALND) with sentinel lymph node biopsy (SLNB) alone in cN0 patients with T1/T2 invasive breast cancer and one to three sentinel node macrometastases undergoing upfront breast-conserving…
-
Artikel Jurnal
Racial disparity in pro-metastatic tumor microenvironment in treatment naïve breast cancer
Abstract Black women with estrogen receptor-positive, HER2-negative (ER + /HER2-) breast cancer experience higher rates of distant recurrence and worse survival outcomes compared to White women. This may be due not only to disparities in social determinants of health, but also differences in the…
-
Artikel Jurnal
Spatial gene expression analysis reveals drivers of extremely early lymph node metastasis in breast cancer
Abstract Lymph node metastasis correlates with breast cancer prognosis; however, the cellular mechanisms underlying the earliest metastatic events remain unclear. In spatial transcriptomic analysis of a patient with breast cancer at single-cell resolution, we identified 30 tumor cells representing…
-
Artikel Jurnal
CD52 signaling via macrophage Siglec-G represents a therapeutic target for cancer immunotherapy
Abstract Triple-negative breast cancer (TNBC) remains a lethal malignancy with limited targeted therapies and high metastatic rates. Cancer cells evade macrophage clearance by overexpressing anti-phagocytic cell surface proteins, termed “don’t eat me” signals. Blocking antibodies (e.g., anti-CD47)…
-
Artikel Jurnal
Breast cancers arising in high mammographic density tissue harbor tumor-promoting immune profiles
Abstract Epidemiological studies have shown that high mammographic density (HMD) is a strong risk factor for breast cancer (BC) and is associated with poor prognosis. Although tumors from women with low (LMD) and HMD are genetically similar, HMD has a worse prognosis. We explored whether…
-
Artikel Jurnal
Monitoring of circulating tumor DNA in patients with stage II-III breast cancer treated with neoadjuvant chemotherapy
Abstract Circulating tumor DNA (ctDNA) has potential as a prognostic factor for predicting relapse in high-risk breast cancer (BC). This study investigates the utility of ctDNA assessment using a tumor-informed assay, in patients with high-risk BC treated with neoadjuvant chemotherapy (NAC). Thirty…
-
Artikel Jurnal
Agonistic CD40 elicits CD8+ T-cell-dependent primary responses and CD4+ T-cell-dependent long-term immunity in breast cancer
Abstract There has been marked improvement in the clinical outcome of triple-negative breast cancer (TNBC) with the use of immune checkpoint blockade (ICB) although serious immune-related adverse effects are not uncommon. However, other subtypes including luminal ER+ and HER2+ breast cancers are…
-
Artikel Jurnal
CRISPR screens identify PRMT7 as a therapeutic target to enhance T cell-mediated killing in breast cancer
Abstract Genome-wide association studies (GWAS) have identified more than 220 loci associated with breast cancer susceptibility, yet identifying effector genes, their modes of action and prioritising therapeutic targets remains a significant challenge. To address this, we performed pooled CRISPR…
-
Artikel Jurnal
Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells
Abstract Myeloid cells are highly heterogeneous and play key roles in establishing an immunosuppressive tumor microenvironment (TME), but the mechanisms controlling their differentiation remain unclear. Using orthotopic murine breast cancer models, we investigated how interleukin-1α (IL-1α)…
-
Artikel Jurnal
Simultaneous inhibition of PARP/AKT to intercept nascent BRCA1/2 mut breast tumors
Abstract We utilized the K14-Cre Brca1 f/f Tp53 f/f mouse model to investigate whether a pulse of PARP inhibitor (PARPi) ± an AKT inhibitor (AKTi) can prevent Brca1-related breast cancer. PARPi alone did not intercept or prevent tumor development. PARPi+AKTi intercepted tumors but did not prevent…
-
Artikel Jurnal
AI-assisted image analysis of tumor-infiltrating lymphocytes as a prognostic marker in chemotherapy-naïve luminal breast cancer
Abstract In triple-negative and HER2-positive breast cancer, tumor-infiltrating lymphocytes (TILs) are established predictive and prognostic biomarkers, but their role in luminal subtypes remains unclear. We investigated the prognostic significance of TILs using AI-based image analysis in 2298…
-
Artikel Jurnal
Dual ctDNA and CTCs analysis for minimal residual disease detection and relapse monitoring in early-stage breast cancer
Abstract Early detection of minimal residual disease (MRD) by liquid biopsy could enable earlier relapse identification in early-stage breast cancer (BC), but most approaches are single-analyte. We prospectively studied 58 patients with early-stage BC, including HR+/HER2−, triple-negative, and…
-
Artikel Jurnal
Targeting microRNA let-7b-5p-mediated aberrant androgen receptor signaling for prevention of hormone receptor-negative breast cancer
Abstract Androgen receptor, the key mediator of the AR signaling pathway, is expressed in the majority of breast cancers and has been emerging as a potential target for treatment with encouraging results in preclinical and clinical trials. But whether AR plays a role in the preneoplastic context to…
-
Artikel Jurnal
Stromal-based proteome data improve stratification of hormone receptor-positive breast cancer
Abstract Breast cancers are biologically and clinically diverse. While large-scale gene expression analyses have enabled epithelial-centered molecular classifications, studies of the tumor microenvironment (TME) remain limited, especially at the proteome level using tissue-specific resolution. By…
-
Artikel Jurnal
Acute circulating tumor DNA dynamics during and after systemic therapy initiation for advanced triple-negative breast cancer
Abstract Circulating tumor DNA (ctDNA) ‘tumor fraction’ (TF) may correlate with therapy response, but little is known regarding TF dynamics immediately after therapy initiation. Plasma samples from a single-arm clinical trial enrolling patients with triple-negative breast cancer were collected at a…
-
Artikel Jurnal
Multimodal analysis of a rare BARD1 missense variant suggests its pathogenicity is conditional
Abstract Hereditary breast cancer involves multiple risk genes, including BARD1, which confers low to moderate risk and is associated with triple-negative breast cancer (TNBC). We report a proband with a primary ER+/PR+/HER2- breast cancer, which recurred unilaterally as a TNBC and who later…
-
Artikel Jurnal
Biomarker, treatment patterns, and survival differences in metastatic triple-negative breast cancer by race in the United States
Abstract Triple-negative breast cancer (TNBC) disproportionately affects Black women, with higher incidence rates and worse outcomes compared with White women. This study included 670 adult patients with metastatic TNBC diagnosed between January 2017 and March 2022 from the Flatiron Clinico-Genomic…