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Scopus
ISSN 2379-3708 · American Society for Clinical investigation · 3.343 artikel di indeks
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Artikel Jurnal
Functional characterization of podocyte-expressed THSD7A in experimental membranous nephropathy
Although the pathogenic role of autoantibodies targeting the podocyte protein THSD7A in membranous nephropathy (MN) is well described, the consequences of autoantibody binding for podocyte homeostasis and the function of THSD7A remain unclear. Here, we induced an MN model in control and…
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Loss of fungal sensing exacerbates liver injury in a murine model of MASLD
Metabolic dysfunction–associated steatotic liver disease (MASLD) is a global health concern with limited interventions. While the role of gut bacteria in MASLD has been extensively studied, the contribution of gut fungi remains largely unexplored. This study investigates the impact of fungal…
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Macrophage ferritin heavy chain/α-synuclein regulatory axis modulates ferroptosis during kidney injury
Macrophages, endowed with remarkable phenotypic plasticity, are essential for orchestrating injury responses and regulating iron homeostasis. Given the central role of ferritin heavy chain (FtH) as a molecular rheostat linking iron sequestration to redox-dependent signaling, we examined how myeloid…
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Hydrogen sulfide alleviates hyperoxia effects on mitochondria in human developing airway smooth muscle
Moderate hyperoxia (30%–60% O2) in premature infants promotes bronchial airway hyperresponsiveness (AHR) via airway smooth muscle (ASM), a key regulator of bronchoconstriction, bronchodilation, and remodeling. Understanding how O2 exposure drives long-term bronchial changes in prematurity is…
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Semaglutide reduces murine blood pressure through the vascular smooth muscle GLP-1 receptor
GLP-1 receptor (GLP-1R) agonists decrease blood glucose and body weight and reduce rates of cardiovascular and renal disease. Although GLP-1R activation lowers blood pressure (BP), the underlying mechanisms remain incompletely understood and have been attributed to weight loss and endothelial cell…
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TNF-α blockade mitigates immune checkpoint–related nephritis in a humanized mouse model
Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), with acute interstitial nephritis (ICI-AIN) being the most common irAE. While the exact mechanism remains unclear, upregulation of IFN-γ and TNF-α pathways has been implicated. This study used a humanized chimeric…
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Inherited human CARD9 deficiency impairs lymphoid cell, but not fibroblast, IL-17–mediated immunity
Nearly 100 individuals have been identified who carry deleterious biallelic germline variants in CARD9 and experience life-threatening, invasive fungal infections caused by Ascomycetes but are otherwise resistant to other infectious agents. CARD9 is an adaptor protein expressed predominantly in…
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Endothelial MHC expression is required to initiate T cell–mediated rejection of 3D-printed skin grafts
Vascularized skins were 3D printed using single donor human fibroblasts, pericytes, keratinocytes, and endothelial cells (ECs), the latter either unmodified (WT-ECs) or deleted of MHC molecules (KO-ECs). Adult MISTRG6 immunodeficient mice neonatally inoculated with adult human hematopoietic stem…
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Early-life viral infection generates pathological tissue-resident memory cells that contribute to asthma-like disease
Viral lower respiratory tract infections are common early in life and are associated with long-term development of asthma, a chronic condition defined by reversible airflow obstruction secondary to inflammation. Understanding the immunological mechanism connecting these two pathologies observed…
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Atypical memory B cell clonal expansion and inflammatory programs associate with platelet-activating antibody development in COVID-19
Patients with COVID-19 who develop platelet-activating antibodies represent a subset at heightened thrombotic risk, yet the immune features associated with this response remains to be defined. We applied single-cell RNA-seq of B and T cells, single B cell V(D)J-seq, and plasma cytokine and…
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Artikel Jurnal
Epithelial SLPI expression in severe inflammatory bowel disease relates to high IL-17 and neutrophil programming
Heterogeneity in disease severity and treatment response in inflammatory bowel disease (IBD) likely evolves from individual differences in host-microbiota-immune interactions. Histological evaluation of intestinal biopsies is central to diagnosis, but histological parameters that define underlying…
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Single-cell profiling reveals epithelial and immune responses in BK polyomavirus–infected human kidney biopsies
INTRODUCTION BK polyomavirus (BKV) infection is associated with injury and subsequent graft loss due to the extent of injury or rejection. However, the molecular mechanisms driving injury and subsequent adverse outcomes remain poorly understood.METHODS In a cross-sectional study, single-cell…
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FOSL2 regulates endothelial cell state and chromatin accessibility in systemic sclerosis pulmonary vascular remodeling
Systemic sclerosis (SSc) is characterized by fibrosis and vasculopathy affecting the skin and internal organs, leading to multiorgan dysfunction. Injury of microvascular endothelial cells (ECs) in SSc impairs blood flow and causes tissue ischemia, leading to vascular complications such as…
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Bone morphogenetic proteins 4 and 7 increase human white and brown adipocyte thermogenic capacity
Adipocytes exist along a functional spectrum: white adipocytes are energy storing, and brown adipocytes have thermogenic capacity such that activation may counteract obesity-related disease. In between are UCP1-expressing beige adipocytes, which can transition between these two energetic states. We…
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TIGAR deficiency enhances cardiac resilience through epigenetic programming of Parkin expression
Mitochondrial dysfunction devastates the heart in major cardiovascular diseases, yet the mechanisms governing mitochondrial quality control remain elusive. We discovered that TIGAR (TP53-induced glycolysis and apoptosis regulator) deficiency established profound cardiac protection through…
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RAS signaling in lung adenocarcinoma is defined by lineage context and DUSP4 loss
BACKGROUND The molecular landscape of lung adenocarcinoma (LUAD) is often illustrated as a driver-oncogene pie chart, but identical mutations exhibit heterogeneous signaling shaped by comutations, transcriptional programs, and lineage context. We propose a lineage-integrated signaling framework…
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Artikel Jurnal
Glucagon promotes net hepatic glycogen repletion following meal ingestion
Insulin and glucagon are described as having opposing actions on hepatic glycogen metabolism. However, here we showed that their coordinated action promoted glycogen turnover and meal glucose storage. In mice, pharmacological doses of insulin or glucagon failed to alter hepatic glycogen, but the…
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Lysophosphatidic acid mediates skeletal muscle fibrosis in denervation via activation of YAP/TAZ
Lysophosphatidic acid (LPA) is a bioactive lipid that signals through G protein–coupled receptors (LPA1–6) and regulates multiple cellular processes, including fibrosis. Although LPA signaling has been implicated in fibrotic diseases in several organs, its role in skeletal muscle remains unclear…
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High-dose influenza vaccine augments serological and cellular immunity of older people with HIV
BACKGROUND High-dose influenza vaccine, containing 4 times more antigen than the standard dose, is recommended for people 65 years or older, but there is a knowledge gap surrounding its effect in people with HIV (PWH), who remain more vulnerable to serious influenza infections than people without…
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