3.505 hasil
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mSystems
Scopus
ISSN 2379-5077 · American Society for Microbiology · 3.505 artikel di indeks
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Artikel Jurnal
Two solutions for efficient light-harvesting in phototrophic Gemmatimonadota
ABSTRACT Phototrophic Gemmatimonadota represent a unique group of phototrophic bacteria that acquired a complete set of photosynthetic genes via horizontal gene transfer and later evolved independently. Gemmatimonas (Gem.) phototrophica contains photosynthetic complexes with two concentric…
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Artikel Jurnal
Genomic and functional characterization of the L‑sorbose phosphotransferase system in high-risk Escherichia coli lineages
ABSTRACT Certain Escherichia coli strains belong to international high-risk clonal lineages exhibiting a combination of multidrug resistance, enhanced fitness, and increased virulence, posing major public health challenges. Investigation of characteristics beyond antibiotic resistance genes and…
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Artikel Jurnal
Metagenomic, metabolomic, and sensorial characteristics of fermented Coffea arabica L. var. Castillo beans inoculated with microbial starter cultures
ABSTRACT Coffee is one of the most important and widely consumed drinks around the world, and fermentation plays a pivotal role in shaping its quality. This research explores the impact of co-fermentation with “starter cultures” on the sensory and metabolic profiles, as well as on the dynamics of…
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Gempipe: a tool for drafting, curating, and analyzing pan and multi-strain genome-scale metabolic models
ABSTRACT Genome-scale metabolic models (GSMMs) can mechanistically explain phenotypic differences among closely related bacterial strains. However, high-throughput multi-strain reconstructions of GSMMs are still challenging: reference-based methods inherit curated information while missing new…
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Artikel Jurnal
Co-culture metabolomics: a powerful tool for uncovering host-pathogen phenotypes driving Burkholderia infections
ABSTRACT Melioidosis, caused by the soil-dwelling pathogen Burkholderia pseudomallei (Bt), is a severe respiratory infection with limited treatment options. To investigate the host-pathogen metabolic interplay occurring during these intracellular infections, Hicks et al. built upon an in vitro…
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Artikel Jurnal
Orthogonal chemical genomics approaches reveal genomic targets for increasing anaerobic chemical tolerance in Zymomonas mobilis
ABSTRACT Genetically engineered microbes have the potential to increase efficiency in the bioeconomy by overcoming growth-limiting production stress. Screens of gene perturbation libraries against production stressors can identify high-value engineering targets, but follow-up experiments needed to…
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Artikel Jurnal
Hidradenitis suppurativa patients exhibit a distinctive and highly individualized skin virome
ABSTRACT Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by recurring skin lesions. Despite ongoing research, the exact cause underlying initiation and progression of disease remains unknown. While prior research has linked the skin microbiota to HS pathology, the role…
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Updated Erdman reveals tandem repeat copy number is phase-variable and impacts M. tuberculosis adaptation across evolutionary timescales
ABSTRACT High-quality reference genomes are essential for comparative genomics and accurate genotype-phenotype mapping. Here, we corrected the Mycobacterium tuberculosis Erdman strain reference genome (ErdmanTI) using ultra-deep HiFi sequencing. Among the small variants (n = 275) between ErdmanTI…
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Artikel Jurnal
Distinct properties of human pathogenic Candida species revealed by systematic comparative phenotypic screening of clinical isolates
ABSTRACT Fungi associated with humans include several Candida species that rely on phenotypic plasticity for persistence and pathogenicity. Key adaptive traits, such as adherence, stress resistance, and biofilm formation, enable survival in diverse host niches. However, the degree of intra- and…
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Artikel Jurnal
Dynamic reworking of marine diatom endometabolomes in response to temperature and a model bacterium
ABSTRACT A large annual carbon flux occurs through the surface ocean’s labile dissolved organic carbon (DOC) pool, with influx dominated by phytoplankton-derived metabolites and outflux by heterotrophic bacterioplankton uptake. We addressed the dynamics of this carbon flow between microbial primary…
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Artikel Jurnal
A web-based atlas for exploring post-transcriptional regulation in the archaeon Sulfolobus acidocaldarius
ABSTRACT The archaeal domain contains organisms that are well-adapted to extreme conditions and changes in their habitat. Post-transcriptional regulation plays a key role in environmental adaptation, including rapid molecular responses to stress conditions. To understand the importance of RNA-based…
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Artikel Jurnal
Reduced glutathione levels in Enterococcus faecalis trigger metabolic and transcriptional compensatory adjustments during iron exposure
ABSTRACT Enterococcus faecalis, a facultative anaerobic pathogen and common constituent of the gastrointestinal microbiota, must navigate varying iron levels within the host. This study explores its response to iron supplementation in a glutathione-deficient mutant strain (Δgsh). We examined the…
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Artikel Jurnal
Integrative multi-omics analysis reveals gut-skin axis mechanisms and novel therapeutic target GALE in atopic dermatitis
ABSTRACT The gut-skin axis represents a critical but poorly understood pathway in atopic dermatitis (AD) pathogenesis. This study aimed to establish causal relationships between gut microbiota and AD risk while identifying key molecular bridges and therapeutic targets. We integrated multiple…
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Artikel Jurnal
Isolation and characterization of marine microorganisms capable of degrading plastics
ABSTRACT The escalating crisis of global plastic pollution has prompted increasing efforts toward the identification of plastic-degrading microorganisms as environmentally sustainable solutions. Despite marine ecosystems being the most affected, the systematic exploration of culturable…
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Artikel Jurnal
The tomato seed microbiome is mainly shaped by host genotype and production site
ABSTRACT The seed microbiome plays a crucial role in plant health and productivity, yet the extent to which the plant genotype influences its composition remains unclear. We conducted a large-scale study using 100 tomato (Solanum lycopersicum L.) genotypes from 12 geographical locations in China…
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Artikel Jurnal
Virtual Colon: spatiotemporal modeling of metabolic interactions in a computational colonic environment
ABSTRACT Host-microbial metabolic interactions have been recognized as an essential factor in host health and disease. Genome-scale metabolic modeling approaches have made important contributions to our understanding of the interactions in such communities. One particular such modeling approach is…
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Artikel Jurnal
The best from both disciplines: integrating human and microbial signatures from whole genome sequencing to advance cancer diagnostics
ABSTRACT Liquid biopsies are transforming oncology, enabling earlier diagnosis, dynamic treatment guidance, and personalized precision medicine, yet current approaches focusing mainly on circulating host cell-free DNA (cfDNA) neglect crucial information within co-existing microbial cell-free DNA…
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Artikel Jurnal
Molecular characterization of a clinical ST145 Klebsiella oxytoca strain co-producing KPC-2 and IMP-96 carbapenemases
ABSTRACT The objective of this study was to investigate the antimicrobial resistance phenotype and genetic characteristics of a clinical ST145 Klebsiella oxytoca isolate co-producing KPC-2 and IMP-96 carbapenemases. The isolate was first identified by MALDI-TOF MS. PCR and Sanger sequencing were…
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Artikel Jurnal
Nutrient limitation shapes functional traits of mycorrhizal fungi and phosphorus-cycling bacteria across an elevation gradient
ABSTRACT In nutrient-limited high-elevation ecosystems, plants rely on arbuscular mycorrhizal (AM) fungi to provide mineral phosphorus (P) in the form of phosphate (PO43−). AM fungi gather these nutrients from phosphorus-cycling bacteria (PCBs) that can mineralize PO43− from organic matter and…
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