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Bioengineering & Translational Medicine
Scopus
ISSN 2380-6761 · Wiley · 743 artikel di indeks
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Artikel Jurnal
Hypoxia‐preconditioned MiotEVs from bone marrow mesenchymal stem cells inhibit myocardial infarction‐induced cardiac fibrosis
Abstract Hypoxia‐preconditioned bone marrow mesenchymal stem cell‐derived mitochondrial extracellular vesicles (Hypoxia‐BMSC MitoEVs) emerged as a novel therapeutic candidate for myocardial infarction (MI)‐induced cardiac fibrosis. Here, we demonstrate that MitoEVs isolated from hypoxic BMSCs, rich…
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Artikel Jurnal
Glioma chemotherapeutic resistance is tied to membrane electrophysiological properties and glycosylation
Abstract Diffuse gliomas are brain tumors that include oligodendroglioma, astrocytoma, and glioblastoma (GBM), the most common and deadly primary brain tumor. A major challenge in glioma treatment is resistance to the first‐line chemotherapeutic, temozolomide (TMZ). Plasma membrane properties of…
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Artikel Jurnal
Quantitative determination of embolization endpoints based on local arterial pressure
Abstract This study aims to optimize the embolization endpoint to improve therapeutic outcomes in interventional procedures and minimize the risk of ectopic embolism caused by excessive embolic agent injection. Hemodynamic changes during embolization were simulated by modeling the terminal…
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Artikel Jurnal
Vitrification and rapid rewarming of precision‐cut liver slices for pharmacological and biomedical research
Abstract High‐throughput in vitro pharmacological toxicity testing is essential for drug discovery. Precision‐cut liver slices (PCLS) provide a robust system for screening that is representative of the complex 3D structure of the whole liver. However, PCLS are not available as off‐the‐shelf…
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Artikel Jurnal
Transcatheter measurement of mitral valve coaptation pressure: A proof‐of‐concept study using animal models
Abstract Mitral valve repair (MVr) is the preferred surgical treatment for primary mitral regurgitation; however, its success is limited by the lack of validated, accurate, and objective parameters for assessing the complete restoration of physiological mitral valve (MV) mechanics. Consequently, to…
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Artikel Jurnal
Revolutionizing nephrocalcinosis treatment: IL‐10 engineered macrophages as a novel therapeutic approach
Abstract Nephrocalcinosis provides a nidus for stone formation and is strongly linked to renal injury and chronic kidney disease. Although the crucial role of macrophages in the formation and progression of calcium oxalate (CaOx) crystals has long been widely recognized, finding effective…
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Artikel Jurnal
Injectable hyaluronic acid–metformin conjugate gel for sustained intra‐articular delivery and prevention of post‐traumatic osteoarthritis
Abstract We developed an injectable hyaluronic acid–metformin (HA–Met) conjugate gel for localized intra‐articular delivery to mitigate post‐traumatic osteoarthritis (PTOA). Conjugation was verified by Fourier‐transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and…
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Artikel Jurnal
Site‐specific noninvasive delivery of retrograde viral vectors to the brain
Abstract Neuronal activity underlies the brain function. Different behaviors, physiological processes, and disorders depend on which neurons are active at a given moment. Treating brain disorders without side effects will require exclusive control of disease‐relevant neurons. Traditionally, small…
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Artikel Jurnal
Precise mimicry of physiological Ca2+ oscillations for mammalian oocyte activation by nanosecond pulsed electric field
Abstract Oocyte activation deficiency is a primary cause of fertilization failure following intracytoplasmic sperm injection, a problem that can potentially be overcome through artificial oocyte activation (AOA). However, concerns persist regarding the safety and efficacy of AOA in clinical…
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Artikel Jurnal
Revolutionizing cancer treatment: The multifaceted role of graphene oxide in modern oncology
Abstract The rising global incidence and mortality rates of cancer underscore the persistent reliance on chemotherapy as the primary treatment modality. Despite its widespread use, challenges such as chemotherapy resistance and the absence of tumor‐specific targeting have limited its efficacy…
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Artikel Jurnal
Therapeutic potential and translational challenges of extracellular vesicles in neonatal medicine
Abstract Extracellular vesicles (EVs) have emerged as promising therapeutic candidates for a range of neonatal diseases, including sepsis, necrotizing enterocolitis, hypoxic–ischemic encephalopathy (HIE), and bronchopulmonary dysplasia (BPD). Derived from diverse sources such as mesenchymal stem…
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Artikel Jurnal
Viral vector‐based gene therapies in the clinic: An update
Abstract Gene therapy has advanced considerably in recent years, driven by innovations in vector engineering and a more advanced understanding of virology for clinical translation. Since 2021, the U.S. Food and Drug Administration (FDA) has approved seven new viral vector‐based gene therapies, five…
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Artikel Jurnal
Renal‐targeted exosomes inhibiting miR‐182‐5p for treatment of renal ischemia–reperfusion injury
Abstract Renal ischemia–reperfusion injury (IRI) is a significant condition that leads to acute kidney injury, exacerbating the progression of renal failure clinically and affecting the patient's prognosis. Following the identification of miR‐182‐5p as a significant molecule in IRI, we conducted a…
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Artikel Jurnal
Three‐dimensional modeling of flow through microvascular beds and surrounding interstitial spaces
Abstract The health and function of microvascular beds are dramatically impacted by the mechanical forces that they experience due to fluid flow. These fluid flow‐generated forces are challenging to measure directly and are typically calculated from experimental flow data. However, current…
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Artikel Jurnal
Low‐cost, handheld, multi‐pulse electroporators for simplified nucleic acid delivery in skin
Abstract Electroporation‐mediated delivery offers a promising alternative to carrier‐based nucleic acid delivery methods for vaccination and therapeutic applications. Carrier‐based systems like lipid nanoparticles and viral vectors often suffer from poor in vivo stability, immunogenicity, toxicity…
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Artikel Jurnal
Patient‐specific visco‐hyperelastic mechanical model for breast tumor localization in surgical planning
Abstract Breast‐conserving surgery is typically performed with the patient in a supine position, whereas preoperative diagnostic MRI breast images are obtained with the patient in a prone position. The change in patient positioning causes significant large deformations, requiring preoperative…
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Artikel Jurnal
Kidney organoids as a novel platform to evaluate heat‐stress‐induced acute kidney injury pathogenesis
Abstract Acute kidney injury (AKI) is a serious condition with significant global impact. To explore mechanisms and biomarkers of heat‐stress‐induced AKI, we used human kidney organoids derived from induced pluripotent stem cells via suspension culture. Organoids were exposed to 37, 39, and 41°C…
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Artikel Jurnal
Tissue‐specific gene delivery approaches
Abstract For genetic therapies to have their intended benefit, delivery systems must be designed which reach disease‐affected organs with high efficiency. To accomplish this, gene delivery systems must overcome multiple intra‐ and extracellular barriers to avoid rapid clearance from the body and/or…
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Artikel Jurnal
A multifactorial intervertebral disc degeneration model: Integrating inflammation, structural disruption, biomechanical parameters, and neural sensitization
Abstract Intervertebral disc (IVD) degeneration (IVDD) is a major cause of low back pain, yet treatment options remain limited. Robust IVDD models are essential for discovering and validating new regenerative treatments. Ex vivo whole organ bioreactor cultures using bovine IVDs are a…
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Artikel Jurnal
Physiological and functional characterization for high‐throughput optogenetic skeletal muscle exercise assays
Abstract Exercise promotes human mobility by tuning the function of skeletal muscle, and recent studies highlight exercise's broader impacts on human health via muscle's paracrine and endocrine roles beyond force generation. In vitro models of tissue engineered skeletal muscle enable precise…