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Vaccine Research
ISSN 2383-2819 · Pasteur Institute of Iran · 132 articles in the index
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Journal Article
Production of Polyomavirus and Herpesvirus Recombinant Glycoproteins with Immunoreactivity Using a Rapid and Novel Expression System in Insect Cells for Applications in Vaccines and Serological Assays
Introduction: Although, conventional methods for the expression of polyomaviruses and herpesviruses recombinant proteins for serological assays and vaccine developments in baculoviruses are well established, the manipulations are laborious and time consuming. Methods: A new expression system based…
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Journal Article
Cutaneous Reactions after COVID-19 vaccines
Cutaneous reactions reported post COVID-19 trials range from acute and immediate to delayed reactions. The suspected trigger for hypersensitivity reactions is the inactive ingredients, such as polyethylene glycol in mRNA vaccines and polysorbate 80 in AstraZeneca. Localised or injection- site…
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Journal Article
Assembling the Most Antigenic Peptides of COVID-19 Immunogenic Proteins Along with a Molecular Adjuvant to Develop a Novel Polyepitope Vaccine: a Bioinformatics Investigation
Introduction: Many countries are presently concerned about providing a safe vaccine with minimal side-effects against COVID 19. Here, we aimed to develop a multiepitope vaccine by utilization of spike, envelope, nucleocapsid and membrane proteins of SARS-CoV-2 virus. Methods: Online servers were…
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Journal Article
Comparative Study of AEFI of Hepatitis B Vaccine between Iran Ministry of Health CDC and VAERS Data during 2015 to 2017
Introduction: Hepatitis B Vaccine (HBV) is a safe and effective vaccine that is nowadays recommended for all infants at birth as well as adults who could be exposed to hepatitis B virus. HBV can provide lifetime protection against hepatitis B virus infection. Despite its highly effective disease…
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Journal Article
Analysis and Control of an SEIQR Epidemic Model with Application to Ebola Disease Vaccination
Introduction: A modified Susceptible - Exposed - Infected - Quarantined - Recovered (SEIQR) epidemic model with vaccination is considered to understand the transmission dynamics of Ebola disease. Methods: The impact of vaccination as a control strategy is investigated in two cases: vaccination is a…
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Journal Article
Quantitative Approaches for Causality Assessment of Adverse Events Following Immunisation for COVID-19 Vaccines
Vaccine safety surveillance is important to identify and manage adverse events following immunisation (AEFI) and avoid vaccine hesitancy. Currently, COVID-19 vaccines are administered to large numbers of people to try and curb the pandemic. In this paper, quantitative methods for causality…
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Journal Article
Comparative Sequence Analysis, Pathogenicity and Immunogenicity of Attenuated Fowl Adenovirus Isolates as Experimental Vaccines against Inclusion Body Hepatitis of Commercial Broiler Chickens
Introduction: Fowl adenoviruses (FAdV) cause inclusion body hepatitis (IBH) in chickens and new vaccination strategies against IBH are needed as an effective control measure in the poultry industry. Methods: The attenuated FAdV isolates from from chicken embryonated (UPM1137E20) and cell culture…
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Journal Article
Construction and Rescue of a Rabies Virus with Duplicated Glycoprotein Gene
Introduction: Rabies is almost always fatal but entirely preventable through proper vaccination. Inadequacy of costly high-quality cell culture vaccines is sometimes a bottleneck for expanded rabies control plans. Reverse genetics along with other molecular biology means are trying to improve the…
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Journal Article
Two Months Follow-Up of 139 Unvaccinated COVID-19 Patients Based on Clinical and Imaging Data
Introduction: To understand the effects of COVID-19 vaccines it would be essential to have knowledge about the effects of the disease during the time that vaccines were unavailable. Hence, we tracked the clinical outcomes of Iranian COVID-19 patients during Feb 19th till May 1st 2020 by a…
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Journal Article
Potent Therapeutic Efficacy of a Novel HPV16E7-HBcAg-Hsp65 Fusion Protein Vaccine
Introduction: Cervical cancer is the fourth leading cause of cancer death in women worldwide. Nearly all cervical cancers are resulted from high-risk Human Papillomavirus (HPV) infection. Currently, there is no available HPV-specific therapy. Cancer therapeutic vaccines have shown anti-tumor…
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Evaluation of the effectiveness of infectious diseases immunoprophylaxis (review of our own research on the model of tick-borne encephalitis)
Introduction: The tick-borne encephalitis (TBE) virus causes a dangerous neuroinfection in humans can serve as a model for studying the mechanisms of interaction of pathogens with specific antibodies during active and passive immunization. Several commercial vaccines are currently used against TBE…
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Journal Article
Pulmonary Thromboembolism Followed by Deep Vein Thrombosis In A Young Man With G6PD Deficiency After ChAd0x1 nCoV-19 Vaccine Administration
Recently the term vaccine-induced immune thrombotic thrombocytopenia (VITT) used for individual which have thrombotic phenomena followed by ChAdOx1 nCoV-19 vaccine (AstraZeneca) administration against SARS coronavirus. Here we report the 27 years old healthy male and known case of G6PD deficiency…
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Journal Article
Back to the Basics: The Good Old BCG for COVID-19?
The outbreak of SARS-CoV-2 from Wuhan, China in late 2019 and the subsequent worldwide pandemic in 2020 [1] are pushing scientists to look for urgent and efficient ways of protecting patients and managing positive cases, and a real “race for a cure” is running forward, but also backward! In fact…
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Journal Article
Recombinant vaccines against Newcastle Disease: current trends and research agenda
Decades after the production of recombinant vaccines, the production of large scale and commercial use of such vaccines has become an important issue in the academic community. Newcastle disease is an infectious and highly contagious viral disease that causes diseases with different virulence and…
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Journal Article
Assessment of Peste Des Petits Ruminants Antibodies in Vaccinated Yankasa Pregnant Ewes from Nigeria and the Duration of Maternal Immunity in Their Lambs
Introduction: Peste des petits ruminants (PPR) or goat plague is a highly contagious viral disease of small ruminants such as sheep and goats with 90% and 100% morbidity and mortality, respectively. This study was aimed at assessing Peste des petits Ruminants Virus (PPRV) specific antibodies in…
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Journal Article
Design and Recombinant Expression of a multiepitope Vaccine Candidate Against Pathogenic Species of Shigella
Introduction: Shigellosis is a form of acute intestinal infection and one of the global health problems that occur in human by pathogenic species of Shigella. Producing a cost-effective and protective vaccine against the pathogenic strains of these bacteria will have a significant effect on the…
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An Assessment of the 2017-2018 Post Measles Campaign Coverage Survey in the South-south Zone of Nigeria
Introduction: The World Health Organization (WHO) recommends measles vaccination campaigns as an effective strategy that is required to halt and revert the burden of measles worldwide, especially in the African region. This is a review of the 2017/2018 measles campaign in South-south Zone, Nigeria…
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Characterization and Inactivation of Infectious Bursal Disease Virus for Use as a Vaccine and Immunodiagnostic Reagent
Introduction: Poultry vaccines are used to immunize chickens against different diseases. Inactivated vaccines have been widely used to protect poultry against diseases such as infectious bursal disease (IBD). IBD is one of the most important viral immunosuppressive diseases in the poultry industry…
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Journal Article Full text
Combination of Chitosan and Myxovirus Resistance Oligonucleotide: An Efficient and Safe Natural Adjuvant against Influenza Virus
Introduction: Avian influenza virus causes severe economic losses to the poultry industry and has a great potential for becoming a pandemic threat for humans. The application of natural adjuvants has opened up new avenues toward reaching a highly efficient and safe vaccine in recent years. In this…
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Journal Article Full text
Murine Dendritic Cells for Immunotherapy and Vaccine Development: Generation, Optimization and Transduction
Introduction: Dendritic cells (DCs) play crucial roles in cellular immunity as the most powerful antigen presenting cells. They have been widely used for antigen delivery in vivo and in vitro. There are different ways to generate DCs and also gene transduction. In this study we introduce some…