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Pharmaceutical Sciences
Scopus
ISSN 2383-2886 · Tabriz University of Medical Sciences · 567 articles in the index
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Effects of Ginger Administration on Mild Cognitive Impairment (MCI): A Randomized Double-Blind Clinical Trial
Background: Mild Cognitive Impairment (MCI) is considered a cognitive impairment more than expected for an individual’s age and education without interference with daily life. However, current treatment options for MCI have limited curative effects and mainly focus on symptomatic management. In…
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Identification of Key Pathways and Hub Genes in Breast Cancer Via a Systems Biology Approach
Background: Breast cancer (BC) remains the leading cause of cancer-related mortality among women globally. Despite significant advances in diagnosis and treatment, the molecular mechanisms driving breast tumorigenesis are not yet fully elucidated. This study aimed to identify key genes and…
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Investigation of Nose-to-Brain Transportation of Peptide-Displaying Bacteriophage Particles Using Phage Display Method
Background: Brain drug delivery is of paramount significance in CNS-related diseases as blood brain barrier (BBB) permeability is not feasible for many pharmaceutical agents. The purpose of this study was to identify peptide sequences with specific translocation property into brain via intranasal…
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A Molecular and Computational Study on the Effects of 5-Fluorouracil, and Dicyclomine on AGS Cells: Regulation of P53 and SNAIL2 Pathways
Background: 5-Fluorouracil (5-FU) is commonly used to inhibit gastric cancer (GC) cell growth, but its clinical effectiveness is frequently limited by chemoresistance. Dicyclomine (DIC), an anticholinergic agent, has been suggested to enhance the therapeutic effect of 5-FU in cancer treatment…
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In Vivo Pharmacokinetic and Therapeutic Evaluation of Tizanidine Cubosomal Gel Versus Oral Solution
Background: Cubosomes are nanostructured lipid carriers with a bicontinuous cubic phase that can encapsulate both hydrophilic and lipophilic drugs, making them promising systems for transdermal delivery. Tizanidine (TZN), a centrally acting α2-adrenergic agonist, exhibits limited oral…
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Evaluation of the Effects of 8 Weeks of High-Intensity Interval Training Combined with Niosome-Encapsulated Yerba Mate (Ilex paraguariensis A. St.-Hil.) Extract on Inflammatory and Oxidative Stress Markers in Rats with Cigarette Smoke–Induced Lung Injury
Background: Chronic obstructive pulmonary disease (COPD) is characterized by persistent inflammation and oxidative stress, primarily driven by cigarette smoke (CS) exposure. While high-intensity interval training (HIIT) and polyphenol-rich supplements such as Yerba Mate (YM) have demonstrated…
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Development and Characterization of a Novel Hydrogel Dressing for Co-Delivery of Resveratrol and Gallic Acid Via Cyclodextrin Inclusion Complexation for Wound Healing
Background: The therapeutic potential of polyphenols like resveratrol (Res) and gallic acid (GA) in wound healing is limited by their poor aqueous solubility and chemical instability. This study aimed to develop and characterize a novel hydrogel-based drug delivery system to overcome these…
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Modulation of Bilastine Crystallinity for Enhanced Dissolution and Oral Bioavailability
Background: Bilastine is a second-generation antihistamine belonging to poorly soluble, highly permeable drug class. This resulted in low and variable oral bioavailability. Being antihistaminic, its combination with caffeine is possible. Accordingly, the aim was to research bilastine/caffeine solid…
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A Laser Monitoring Technique for Investigating the Solubility and Thermodynamic Properties of Ivermectin in Aqueous Mixtures of Ethylene Glycol
Background: Ivermectin (IVM) is a broad-spectrum antiparasitic drug used in humans and animals to treat infections like scabies, river blindness, and various worms. Derived from avermectin via fermentation, IVM contains impurities and degradation products. During pandemics like COVID-19, demand for…
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Analyzing Hair Damage Caused by SLS and SLES: Correlation Between Lowry Method and Zein Test
Background: This study aimed to investigate the impact of sodium lauryl sulfate (SLS) and sodium lauryl ether sulfate (SLES), two anionic surfactants, on human hair at different pH levels and temperatures, using the Lowry method and Zein tests to assess hair damage and to check the Zein test’s…
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A Folic Acid-Modified Polymeric Nanoliposome for Tumor-Targeted Drug Delivery
Background: Nowadays, scientists are trying to design a developed carrier for delivering drugs specifically to cancerous cells. This study aimed to design the poly (acrylamide-maleic anhydride)/(FA & TPGS) coated nanoliposome (P(AAm-MA)/(FA & TPGS) NL) as an FA-modified targeted drug delivery…
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Development and Characterization of Colloidally Stable Dendrimer–Botox Conjugates for Targeted Muscle Delivery and Radiolabeled Imaging
Background: Botox’s therapeutic applications are limited by its instability and uncontrolled diffusion into extramuscular tissues. This study aims to develop a polyethylene glycol-based formulation by conjugating Botox to a second-generation anionic linear-globular dendrimer (G2-ALGDs) and evaluate…
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Integrative Review of Vaccinium arctostaphylos L.: Phytochemical Composition, Biological Activities, Comparative Insights, and Future Development Prospects
Vaccinium arctostaphylos L. (Ericaceae), is a medicinal shrub that commonly found in Caucasus and western Asia (Iran and Turkey). Traditionally, this plant has been employed for its antidiabetic and antihypertensive effects. Recent studies have indicated that V. arctostaphylos contains several…
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Advancements in Gastroretentive Drug Delivery Systems: A Review on Sublimation Technique in Floating Tablet Formulations
Gastroretentive drug delivery systems (GRDDS) have emerged as a highly promising strategy to achieve better therapeutic outcomes and enhance patient compliance in oral drug delivery systems. Among the GRDDS, conventional effervescent floating tablets are the most frequently implemented. However…
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Pentoxifylline Effects on Late-Onset Sepsis in Preterm Neonates: A Pilot Randomized Clinical Trial
Background: Despite the progress in the management of late-onset sepsis (LOS), it is the leading cause of mortality in preterm infants worldwide. Pentoxifylline is a methylxanthine with well-documented immunomodulatory properties, which may be an important approach to treating LOS.This study aimed…
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Solubility of Different Polymorphs of Drugs in Mono- and Mixed-Solvents at Various Temperatures
Background: Solubility of drugs is an important issue in pharmaceutical industry and the solubility of polymorphs play a critical role in dealing with the solubility issue. This work summerizes the effects of crystal structure on drug’s solubility with special focus on the modeling approaches…
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New Morpholine/aryl Carbonyl Thioureas as Antimetastatic Candidates Against Gastric Cancer Cells
Background: Inhibition of cancer cell migration is an appropriate strategy for the prevention of metastasis. The purpose of this study was to identify new carbonyl thioureas as inhibitors of gastric cancer cell migration. Methods: N1-(morpholin-4-yl…
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Antihyperlipidemic Constituents of Indonesian Medicinal Plant, Pterospermum javanicum Jungh.
Background: Indonesia, an archipelagic nation, is home to the second-highest biodiversity in the world, which includes Bajur (Pterospermum javanicum Jungh.) leaves, which has been used to treat lipid metabolic disorders. To the best of our knowledge, there is no report on P. javanicum Jungh…
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Melissa officinalis Alleviates Cognitive Impairments in a Mouse Model of Accelerated Aging; Possible Involvement of the Hippocampal Sirt-1/Nrf2/NF-κB Signaling Pathway
Background: Aging is associated with a wide range of cognitive impairments that affect the quality of life in the elderly. This study aimed to assess the neuroprotective properties of the hydro-alcoholic extract of Melissa officinalis L. (HAEMO) on cognitive impairment mediated by the…