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Open Chemistry
Scopus
ISSN 2391-5420 · De Gruyter · 2.592 artikel di indeks
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Artikel Jurnal
Structural and attenuation properties of rare-earth and barium oxide modified borate glasses for gamma ray protection
This research intends to investigate the B2O3–TiO2–BaO–ZnO–La2O3–Nd2O3 glass system’s radiation shielding characteristics at the Cs-137-, Co-60-, and Na-22-emitted energies. The mass attenuation coefficient was investigated in the 0.284–2.506 MeV range, with the maximum value for all glasses of…
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Artikel Jurnal
In silico computational screening and molecular dynamics analysis unveil Moringa oleifera phytochemicals as a promising PPAR-γ receptor agonist for targeted diabetes management strategies
The principal aim of this study was to detect potential pharmacologically active compounds in Moringa oleifera, which have shown promise as therapeutic agents against diabetes mellitus. Phytochemical structures obtained from verified PubChem database, andfurther analysed through molecular docking…
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Protective effects of methanolic broccoli (Brassica oleracea var. italica) extract on metabolic dysfunction and hypothalamo-hypophyseal axis oxidative stress in a rat model of diet-induced type 2 diabetes mellitus
Neurological complications of diabetes require investigation of botanical therapeutic alternatives for management. This study investigated the protective effects of methanolic extract from Brassica oleracea var. italica (broccoli) florets (MEBr) against metabolic dysfunction and neuroendocrine…
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Artikel Jurnal
Targeting QS-mediated virulence in Staphylococcus aureus using Eucalyptus globulus essential oil: from chemistry to molecular docking
Nowadays, there is a huge challenge linked to multi drugs resistant issue; therefore, researchers are seeking alternatives to antibiotics, such as plants essential oils and extracts. Staphylococcus aureus (S. aureus) a pathogenic bacterium, which is associated with several chronic illnesses…
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Artikel Jurnal
Use of a choline chloride-urea based deep eutectic solvent for the improvement of HPLC resolution in complex botanical extracts
Turnera diffusa is a plant with hepatoprotective activity. Hepatodamianol – a biomarker of this plant – is identified as the main compound responsible for this activity. There are no chromatographic methods with adequate peak resolution for quantifying this analyte in T. diffusa extracts. Deep…
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Enhancing anticancer efficacy of miconazole via olive oil-based nanoemulsion: a molecularly-driven approach to drug repurposing
Miconazole, a well-known antifungal drug, has recently gained attention for its potential anticancer properties, prompting efforts to enhance its therapeutic performance through innovative delivery systems. This study explores the repurposing of miconazole for anticancer applications using a green…
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Artikel Jurnal
Role of PbO2 in enhancing radiation shielding efficiency of lead borosilicate glasses
The radiation shielding parameters of lead borosilicate glasses were examined to assess their potential in different radiation shielding applications. The shielding parameters of the investigated glasses were estimated within the 0.0359–1.46 MeV interval. The transmission factor values increase as…
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Artikel Jurnal
Unveiling the bioactive potential of Azaleatin-3,7-di-O-glucoside from Hibiscus rosa-sinensis: in silico insights into its antioxidant and antibacterial properties
Hibiscus rosa-sinensis L. flower has been known to contain polyphenolic compounds, so the current study focuses on the isolation, identification, characterization, and biological applications of flavonoid compounds from H. rosa-sinensis flower, with an emphasis on antioxidant and antibacterial…
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Nigella sativa seeds, oil, and thymoquinone mitigate streptozotocin-induced diabetes in rats; a comparative study
Black seed, or Nigella sativa, is famous for its therapeutic properties, antidiabetic, antioxidant, and anti-inflammatory effects. The study aimed to evaluate the preventive and therapeutic benefits of N. sativa seeds, oil, and its active component, thymoquinone, on diabetic rats that have been…
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Artikel Jurnal
Anticancer and anti-inflammatory potentials of doped CuO and ZnO nanoparticles: a multi-pathway mechanistic study
This study presents a new dopant-engineered nanotherapeutic approach by directly comparing the biological activities of yttrium-doped copper oxide (Y–CuO) and silver-doped zinc oxide (Ag–ZnO) nanoparticles produced through a controlled co-precipitation process. Extensive structural analyses (XRD…
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Artikel Jurnal
Correlation between antioxidant capacity and anti-inflammatory capacity: a case study of six standard antioxidants
Oxidation is a significant contributor to inflammatory responses. However, the association between antioxidant capacity and anti-inflammatory capacity of antioxidants is unclear. This study investigated the correlation between antioxidant capacity and anti-inflammatory capacity for six common…
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Artikel Jurnal
Preparation, optimization, and characterization of ivermectin microemulsion as a potential glioblastoma treatment
The prognosis for glioblastoma multiforme (GBM), a very aggressive brain tumor, is poor, and there are few available treatments. Various oils, cosurfactants, and surfactants were tested for solubility. A pseudo-ternary phase diagram was made using the water-titration method. Box-behenken design…
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Artikel Jurnal
Charge transfer behavior of suspended particles under cathodic polarization in aqueous solutions
This study explores the mechanisms of charge transfer to suspended particles – specifically sulfur, graphite, TiO2, and copper – under cathodic polarization in aqueous sulfuric acid solutions. The experiments were carried out in an electrochemical cell with separated electrode compartments. The…
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Artikel Jurnal
Adhesion performance of magnetite-reinforced epoxy copolymer adhesives evaluated using multi-criteria decision-making methods
This study investigates the adhesive performance of epoxy-based copolymers prepared from glycidyl methacrylate (GMA) and poly(ethylene glycol) methyl ether methacrylate (PEGMEMA), cured with 4,4′-methylenedianiline (MDA) and reinforced with magnetite (Fe3O4) nanoparticles. The influence of PEGMEMA…
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Anti-diabetic and neuroprotective potential of extracts of Achillea millefolium and Achillea wilhelmsii using in vitro, in vivo and ex vivo pharmacological approaches
Herein, antidiabetic and anti-amnesic potentials of crude extract Achillea millefolium (AcMi-Crd) and Achillea wilhelmsii (AcHi-Cr) and subsequent fractions were screened following in vitro analysis, in vivo and ex vivo approaches with added GC-MS analysis. The antidiabetic potential was screened…
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Toxicity assessment of phthalates and binary mixtures on differentiated three-dimensional pancreatic cell model
Currently, the development of new in vitro models and the enhancement of existing ones are increasingly prioritized to significantly reduce laboratory animal use, in line with the 3R principles (replacement, reduction, and refinement) of animal welfare legislation. This study aims to evaluate the…
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Therapeutic applications of green synthesized curcumin conjugated zinc oxide nanoparticles derived from Livistona chinensis in polycystic ovarian syndrome
Polycystic Ovary Syndrome (PCOS) is a prevalent and complex endocrine disorder affecting reproductive-aged women, characterized by hormonal imbalances, ovarian dysfunction, and metabolic disturbances. This study investigates the biological properties of curcumin-conjugated zinc oxide nanoparticles…
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Design, synthesis, and evaluation of antitumor activity of five natural product conjugates
Quercetin, jatrorrhizine, berberine, dehydrocostus lactone, and magnolol are prominent compounds known for their antitumor properties. A series of chemical reactions such as protection, hydrolysis, Michael addition and substitution were conducted using rutin as the initial material to synthesize…
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Artikel Jurnal
Investigating superior environmental microfluidic carbon sequestration using Hydnum repandum-mediated ZnO-nanoconjugates
This study aims to develop an environmentally sustainable microfluidic carbon sequestration system using HR-ZnO nanoconjugates. The nanoparticles are evaluated for their efficiency, stability, and eco-compatibility for enhanced carbon capture applications. The extract (0.1 %) of mushroom was used…
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Artikel Jurnal
Electronic structure and substituent effects in C6-Substituted nicotinamide derivatives: a DFT study
Density functional theory (DFT) calculations were performed to investigate the electronic effects of C6 substitution on the nicotinamide (NA) scaffold. Geometry optimizations, frontier molecular orbital analysis, conceptual DFT descriptors, and molecular electrostatic potential (MEP) analyses were…
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