1.433 hasil
Menampilkan 1–20 · 0,88 detik · RSS
npj Precision Oncology
Scopus
ISSN 2397-768X · Nature Portfolio · 1.433 artikel di indeks
-
Artikel Jurnal
Integrated analysis of radiomics and RNA reveals the biological basis and therapeutic implications of aggressive hepatocellular carcinoma subtypes
Abstract The aggressive subtype of hepatocellular carcinoma (HCC) is associated with a poor prognosis, and histopathological biopsy is the current method used for its diagnosis and tumour microenvironment analysis. Hence, we constructed a radiomics-based artificial intelligence model with robust…
-
Artikel Jurnal
Single nuclei and spatial profiling of sacrococcygeal teratomas reveals cellular composition and X inactivation heterogeneity
Abstract Sacrococcygeal teratomas (SCTs) are the most common neonatal tumors, yet their cellular origins, clinical stratification, and sex bias–occurring three times more in XX than XY individuals—remain poorly understood. To address these gaps, we examined six postnatal (one male and five female)…
-
Artikel Jurnal
Non-invasive epidermis sampling for DNA methylation-based prediction of skin cancer phenotypes
Abstract The epidermis is uniquely exposed to the effects of environmental factors, such as ultraviolet radiation, which induce progressive genetic and epigenetic modifications contributing to aging and the onset of keratinocyte carcinomas. DNA methylation is the best-characterized epigenetic…
-
Artikel Jurnal
Neoadjuvant sintilimab, albumin-bound paclitaxel, and carboplatin for locally advanced, resectable esophageal squamous cell carcinoma: clinical study and mechanistic exploration
Abstract The survival benefits of neoadjuvant chemotherapy combined with immunotherapy in locally advanced esophageal squamous cell carcinoma (ESCC) remain unclear, with treatment responses varying due to tumor microenvironment (TME) heterogeneity. In this phase II study, 24 patients received…
-
Artikel Jurnal
Identification and characterization of MARCO-expressing tumor-associated macrophages in pancreatic ductal adenocarcinoma with pan-cancer relevance
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide. The role of macrophage receptor with collagenous structure (MARCO), a scavenger receptor class-A protein expressed on macrophage surface, in PDAC progression remains unclear. Here, we identified a subset of…
-
Artikel Jurnal
Optical genome mapping as a high-resolution tool for uncovering cytogenetic complex and cryptic alterations in a cohort of patients with MDS and AML
Abstract Cytogenetic and molecular studies are the standard of care in the diagnosis of myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML), which are characterized by a highly heterogeneous genetic landscape. This complexity challenges accurate characterization, risk stratification…
-
Artikel Jurnal
Deciphering brain metastasis in epithelial ovarian cancer: multimodal analysis and potential biomarkers
Abstract Epithelial ovarian cancer (EOC) remains the most lethal gynaecological malignancy in developed countries, with recurrence and drug resistance posing significant clinical challenges. Brain metastases (BM) from epithelial ovarian cancer, once rare, are an increasing phenomenon and are…
-
Artikel Jurnal
Targeted immunotherapies and nanomedicines for ovarian cancer: the way forward
Abstract Ovarian cancer (OC) is the leading cause of death among gynecological cancers, with high mortality due to late diagnosis. Immunotherapy and nanomedicine show potential in targeting cancer cells and inducing immunogenic cell death. However, challenges like poor biodegradability and…
-
Artikel Jurnal
Ultrasensitive ctDNA monitoring reveals early predictors of immunotherapy response in advanced cancer
Abstract Circulating tumor DNA (ctDNA)-based response assessment is appealing but limited by conventional analytical thresholds. We utilized a whole genome sequencing based, tumor-informed ultrasensitive ctDNA assay which tracked ~1800 somatic mutations to analyze 227 longitudinal plasma samples…
-
Artikel Jurnal
Translating spatial transcriptomic signatures in adenosquamous carcinoma into bulk prognostic biomarkers in lung adenocarcinoma: a bottom-up approach
Abstract Spatial transcriptomics enables the detection of rare or transitional tumor states not captured by bulk transcriptomics or immunohistochemistry (IHC). However, translating these spatially defined states into clinically relevant biomarkers is challenging, because signals from minor…
-
Artikel Jurnal
Algorithm-assisted individualized therapy design improves survival in a mouse model of triple-negative breast cancer
Abstract Chemotherapy remains indispensable in the treatment of malignant tumors but is often limited by the prevailing “one size fits all” approach, which neglects inter-patient variablity in pharmacokinetics and treatment response, often resulting in suboptimal outcomes. In this study, we…
-
Artikel Jurnal
Evaluation of immuno-oncologic biomarkers and β-catenin expression in response of hepatocellular carcinomas to immunotherapy
Abstract Immune checkpoint inhibitors (ICIs) are utilized to treat hepatocellular carcinomas (HCC) without validated biomarkers. We sought to identify genomic signatures and immune patterns predicting treatment efficacy in 1,306 HCC patients to evaluate for potential predictive biomarkers…
-
Artikel Jurnal
Treatment adherence and clinical outcomes of osimertinib in minority patients with advanced EGFR mutated NSCLC
Abstract Osimertinib has been one of the most commonly prescribed first-line treatments for EGFR-mutated advanced NSCLC for the last several years for patients with EGFR-mutated non-small cell lung cancer (NSCLC), yet clinical outcomes among racial and ethnic minority patients remain poorly…
-
Artikel Jurnal
Towards the tumor microenvironment scoring methods for immune checkpoint inhibitor response
Abstract Immune checkpoint inhibitors (ICIs) have significantly changed cancer therapy, yet their response rates remain relatively low. Identifying methods for robust prediction is crucial. This study evaluates the efficacy of gene-based methods for deriving predictive tumor-microenvironment scores…
-
Artikel Jurnal
Spatial transcriptomics reveals molecular heterogeneity and subtype-specific therapeutic targets in small cell lung cancer
Abstract Small cell lung cancer (SCLC) is a highly aggressive malignancy with strong associations to smoking, characterized by initial platinum sensitivity followed by rapid recurrence and poor long-term survival. The evolutionary processes driving this high plasticity and intratumoral…
-
Artikel Jurnal
Integrated predictive model for visceral pleural invasion in small NSCLC with high clinical utility
Abstract This study aims to develop and validate a multi-feature integrated imaging fusion (MIIF) model, incorporating deep learning, radiomics features, and computed tomography (CT) findings, for identifying visceral pleural invasion (VPI) in small non-small cell lung cancer (NSCLC). This…
-
Artikel Jurnal
Mitochondrial complex I subunit NDUFS4 overexpression drives glioma progression by regulating mitochondrial function and COX5B
Abstract The current study explores the expression, functional significance, and underlying mechanisms of the mitochondrial protein NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4) in glioma cells. TCGA shows that elevated NDUFS4 expression is consistently observed in glioma tissues, correlating…
-
Artikel Jurnal
TheraMind: a multi-LLM ensemble for accelerating drug repurposing in lung cancer via case report mining
Abstract Published clinical case reports are a valuable yet underutilized source of evidence for drug repurposing. However, systematically identifying relevant reports remains a challenge due to the volume of literature and the diversity of candidate compounds. We present TheraMind, an AI system…
-
Artikel Jurnal
Metastatic progression of pheochromocytoma and paraganglioma occurs via parallel evolution
Abstract Pheochromocytoma (PCC) and paraganglioma (PGL) are neuroendocrine tumors derived from chromaffin cells of the adrenal medulla and ganglia of the autonomic nervous system. Approximately one-third are causatively associated with pathogenic germline variants. Metastatic disease develops in up…
-
Artikel Jurnal
AI-driven virtual screening platform identifies novel NSUN2 inhibitor candidates for targeted cancer therapy: a computational drug discovery approach
Abstract The RNA cytosine-5 methyltransferase NSUN2 is an emerging therapeutic target in precision oncology, with aberrant overexpression driving tumor progression, metastasis, and therapy resistance across multiple malignancies. Despite its critical role in cancer biology, selective small-molecule…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.