228 hasil
Menampilkan 1–20 · 0,15 detik · RSS
Precision Radiation Oncology
Scopus
ISSN 2398-7324 · Wiley · 228 artikel di indeks
-
Artikel Jurnal
Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma
Abstract Background and Purpose Boron neutron capture therapy (BNCT) is an emerging binary‐targeted radiotherapeutic modality with promising potential for treating recurrent or refractory head and neck squamous cell carcinoma. We comprehensively evaluated the safety, efficacy, pharmacokinetics, and…
-
Artikel Jurnal
R3Net: Recursive Residual Refinement Network Architecture for Decoder‐Free Medical Image Segmentation
Abstract Background Medical image segmentation methods based on encoder–decoder architectures often achieve high accuracy but typically require substantial computational resources and contain redundant parameters. Purpose This study aims to develop an efficient decoder‐free segmentation framework…
-
Artikel Jurnal
Exosomal hnRNPA1‐delivered miR‐27a‐3p inhibits the radiation‐induced bystander effect in cervical cancer
Abstract Purpose The radiation‐induced bystander effect (RIBE) refers to biological responses in non‐irradiated cells exposed to signals from irradiated cells and may contribute to tumor control during radiotherapy. Periodic dose heterogeneity caused by the thread effect of helical tomotherapy…
-
Artikel Jurnal
Nomogram integrating MRI radiomics and white matter hyperintensity grading for predicting overall survival in patients with non‐small cell lung cancer and brain metastases receiving whole‐brain radiotherapy
Abstract Objectives To develop and validate a nomogram integrating radiomic features, white matter hyperintensity (WMH) grading, and clinical factors for predicting overall survival (OS) in patients with non‐small cell lung cancer (NSCLC) and brain metastases (BMs) receiving whole‐brain…
-
Artikel Jurnal
Robustness Evaluation of Physical versus Virtual Bolus for Breast VMAT Using RegGAN‐Based Synthetic CT
Abstract Background Volumetric modulated arc therapy (VMAT) for breast cancer with skin involvement requires a bolus to ensure adequate surface dose. Although both physical and virtual bolus methods are clinically established, their dosimetric robustness against interfraction anatomical variations…
-
Artikel Jurnal
Synergistic effects and clinical utilization of radioimmunotherapy for brain metastases from driver mutation‐negative non‐small cell lung cancer
Abstract Brain metastasis (BM) is a common complication of advanced non‐small cell lung cancer (NSCLC). Although immune checkpoint inhibitors (ICIs) have demonstrated efficacy in treating NSCLC‐BM, their clinical benefits are often limited. The combination of radiotherapy (RT) and ICIs has emerged…
-
Artikel Jurnal
Refining the boundaries of the nodal CTV in the middle neck for nasopharyngeal carcinoma
Abstract Purpose In our previous research, we found that the subcompartments formed by the cervical fascia in the supraclavicular region (levels IV, Vb, and lower VI) effectively define the boundaries of the nodal clinical target volume (CTV) for nasopharyngeal carcinoma (NPC). This study aimed to…
-
Artikel Jurnal
Radiotherapy and Immunotherapy In Hepatocellular Carcinoma: Priming the Tumor Immune Microenvironment From Bench To Bedside
Abstract Hepatocellular carcinoma (HCC) remains a leading cause of mortality from cancer worldwide. Surgical resection is the main curative strategy for early‐stage HCC; however, many advanced cases require multidisciplinary management, including radiotherapy and immunotherapy. Recent advances in…
-
Artikel Jurnal
Effects of proton therapy on the tumor immune system and clinical implications: A review
Abstract Proton therapy, an emerging radiation therapy technique, has gained significant attention owing to its unique physical properties and biological effects. This review aims to explore the impact of proton therapy on the tumor immune system and of its combination with other therapies. This…
-
Artikel Jurnal
18F‑FAPI‑04 PET/CT imaging of fibroblast activating protein reveals myocardial injury beyond cancer staging
Abstract Objectives Fluorine 18 (18F)‐labeled fibroblast activation protein inhibitor‐04 (denoted as FAPI‐04) positron emission tomography/computed tomography (PET/CT) has showed excellent diagnostic performance for multiple solid tumors. However, its utility in characterizing myocardial injury has…
-
Artikel Jurnal
Normal tissue complication probability models of late cardiopulmonary toxicity following deep inspiration breath hold for breast cancer adjuvant radiotherapy
Abstract Background and purpose Deep inspiration breath hold (DIBH) is a respiratory control technique designed to minimize cardiopulmonary toxicity induced by adjuvant radiotherapy for left‐sided breast cancer. This study aimed to evaluate the dosimetric effects of DIBH compared with those of free…
-
Artikel Jurnal
Precise delineation of radiation targets for thoracic tumors in the immunotherapy era: From immune mechanisms to clinical practice
Abstract As a core modality for local control of thoracic tumors, including lung and esophageal cancers, radiotherapy (RT) shows synergistic effects with immunotherapy, fundamentally reshaping the landscape of cancer treatment. Given the rapid advancements in immunotherapy, this review explores the…
-
Artikel Jurnal
A new perspective on cancer treatment: the interaction and application prospect between ICIs and radiotherapy
Abstract The interaction between immune checkpoint inhibitors (ICIs) and radiotherapy has significantly improved the treatment outcomes for patients with cancer. ICIs activate the immune system by blocking the programmed death‐1 (PD‐1), programmed cell death‐Ligand 1(PD‐L1), and cytotoxic…
-
Artikel Jurnal
Automated quality assurance of HDR brachytherapy: Evaluation of Dwell‐position accuracy and Dwell‐time linearity via image processing of radiochromic films
Abstract Purpose To develop and validate a fully automated quality assurance method for high‐dose rate (HDR) brachytherapy, enabling the precise evaluation of source dwell‐position accuracy and dwell‐time linearity using radiochromic film analysis and advanced image processing algorithms. Methods A…
-
Artikel Jurnal
Emerging agents for boron neutron capture therapy: Biomolecular carriers paving the way for precision radiotherapy
Abstract Boron neutron capture therapy (BNCT) is an emerging targeted radiotherapy technology that enables precise eradication of tumor cells. The development of efficient boron carriers is crucial for the advancement of BNCT technology. Notably, biomolecular carriers currently represent the only…
-
Artikel Jurnal
A new perspective on radiotherapy in the comprehensive treatment of cancer
Abstract Radiotherapy (RT) has become an indispensable part of modern cancer treatment owing to its efficacy, precision, and safety. With continuous advances in clinical practice, the role of RT in comprehensive cancer treatment has been repositioned. Through a combination of chemotherapy, targeted…
-
Artikel Jurnal
One‐year follow‐up after fractionated ultra‐high‐dose‐rate FLASH radiotherapy in patient with extramammary Paget disease of the scrotum
Abstract Objective Ultrahigh‐dose‐rate radiotherapy (FLASH‐RT) has been shown to reduce radiation‐induced normal tissue injury in preclinical studies. Here, we describe the first patient worldwide to receive fractionated FLASH‐RT. Methods An elderly male patient was diagnosed with extramammary…
-
Artikel Jurnal
Boron‐10 carriers and their applications in boron neutron capture therapy
Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues. As a binary, target‐specific…
-
Artikel Jurnal
Skeletal muscle status and malnutrition as predictors of short‐term radiotherapy response and oral mucositis in head and neck cancer
Abstract Objective This study aimed to investigate whether baseline skeletal muscle status and malnutrition in patients with locally advanced head and neck cancer (HNC) are associated with short‐term treatment outcomes and acute radiation oral mucositis (OM). Methods We retrospectively analyzed…
-
Artikel Jurnal
Combining radiotherapy with CAR‐T cell therapy for solid tumors: Challenges, mechanisms, and future directions
Abstract Chimeric antigen receptor (CAR)‐T cell therapy has achieved significant success in treating hematological malignancies. However, compared to its efficacy against hematologic cancers, the application of CAR‐T cell therapy for solid tumors still faces several challenges. Radiotherapy, an…