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Endocrinology, Diabetes & Metabolism
Scopus
ISSN 2398-9238 · Wiley · 719 artikel di indeks
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Artikel Jurnal
Effectiveness of Saroglitazar in MASLD Patients: A Prospective, Real‐World Assessment of Liver and Metabolic Health
ABSTRACT Background Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) is a significant health concern and is commonly associated with conditions such as dyslipidemia, insulin resistance, and increased risk of cardiovascular disease. Managing MASLD requires addressing both liver and…
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Artikel Jurnal
Targeting the NEK7/NLRP3 Inflammasome Axis: Synergistic Protection of Intravitreal MCC950 and Systemic Metformin Against Diabetic Retinopathy in Rats
ABSTRACT Objective Diabetic retinopathy (DR) is characterised by chronic neuroinflammation where the NLRP3 inflammasome plays a pivotal role. This study investigated the therapeutic potential and underlying mechanism of combining systemic metformin (MET) with intravitreal MCC950, a specific NLRP3…
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Artikel Jurnal
Corticotroph Tumour Type Influences Clinical Behaviour in Patients With Nonfunctioning Pituitary Neuroendocrine Tumours
ABSTRACT Introduction This study aims to describe whether the clinical behaviour of nonfunctioning pituitary neuroendocrine tumours/nonfunctioning pituitary adenomas (NF‐PitNETs/NFPAs) is affected by pituitary cell lineage differentiation, focusing on patients with silent corticotroph tumours…
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Artikel Jurnal
A Nationwide Danish Comparative Effectiveness Study of GLP‐1 RA, SGLT2i and DPP‐4i Treatment on Risk of Stroke, Myocardial Infarction and Mortality in Type 2 Diabetes
ABSTRACT Aims Cardiovascular outcome trials have demonstrated that glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) and sodium–glucose cotransporter 2 inhibitors (SGLT2i) reduce the risk of major adverse cardiovascular events, whereas dipeptidyl peptidase‐4 inhibitors (DPP‐4i) have not shown…
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Artikel Jurnal
Circular RNAs as Biomarkers and Therapeutic Targets in Diabetic Cardiovascular Complications
ABSTRACT Background The global prevalence of diabetes mellitus (DM) is rising rapidly and is projected to reach unprecedented levels by 2035 and 2050, with a disproportionate burden among elderly populations and in low‐ and middle‐income countries. Diabetes‐related cardiovascular complications…
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Artikel Jurnal
The Combined Effects of an Anti‐Inflammatory Diet and Curcumin Supplementation on Thyroid Function and Lipid Profile in Patients With Hashimoto's Thyroiditis: A Double Blind Randomised Clinical Trial
ABSTRACT Background Hashimoto's thyroiditis (HT) is an inflammatory autoimmune disease and patients with HT may benefit from interventions that incorporate anti‐inflammatory components. This study aimed to assess the combined effects of an anti‐inflammatory diet and curcumin supplementation on…
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Artikel Jurnal
Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways
ABSTRACT Background Insulin resistance (IR) is a key factor in metabolic conditions such as type 2 diabetes (T2D) and metabolic syndrome, which significantly impact global health. Serum uric acid (SUA), is the end product of purine catabolism, has increasingly been recognized as a potential…
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Artikel Jurnal
Association Between the Triglycerides‐to‐High‐Density Lipoprotein‐Cholesterol (TG/HDL‐C) Ratio and Chronic Kidney Disease: A Systematic Review and Meta‐Analysis of Observational Studies
ABSTRACT Background The relationship between the triglycerides‐to‐high‐density lipoprotein cholesterol (TG/HDL‐C) ratio and the risk of developing chronic kidney disease (CKD) remains unclear, as CKD is a major health challenge worldwide. This study aimed to investigate the association between the…
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Artikel Jurnal
Therapeutic Potential of Holothuria leucospilota Extract in STZ‐Induced Diabetic Rats: Targeting Inflammation and Apoptosis at the Gene Expression Level
ABSTRACT Introduction Chronic inflammation is a key contributor to diabetes pathogenesis. Marine‐derived bioactive compounds offer a promising source of therapeutic agents. This study investigated the effects of Holothuria leucospilota n‐hexane extract on biochemical and inflammatory markers in…
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Artikel Jurnal
Comparative Analysis of Glucagon Receptor Agonists vs. Resmetirom in MASLD and MASH: Network Meta‐Analysis of Clinical Trials
ABSTRACT Background MASLD and its progressive form MASH represent a global public health challenge due to their rising prevalence and their possible progression to cirrhosis and HCC. Resmetirom, dual (e.g., cotadutide, survodutide), and triple GRAs (e.g., retarutide) have demonstrated potential…
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Artikel Jurnal
Exploring Stakeholder Perceptions and Experience of Biosimilar Insulin Switching: A Scoping Review
ABSTRACT Background The option to switch patients to more cost‐effective biosimilar insulins has been available since 2014, and the market share for these medicines has been slowly increasing since then. This scoping review aimed to identify the current knowledge around stakeholder perception and…
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Artikel Jurnal
Association Between Dietary Fatty Acid Intake With Cardiovascular Disease Risk and Serum Lipid Levels
ABSTRACT Background Despite early interest in the effects of dietary fats on cardiovascular diseases (CVDs), substantial controversy remains regarding the evidence linking different types of fatty acids to CVDs. This study aimed to examine the association between dietary fat intake, CVD risk, and…
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Artikel Jurnal
Antihypertensive Effects of Curcumin/Turmeric Supplementation in Prediabetes and Diabetes: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials
ABSTRACT Introduction Hypertension is a major cardiovascular risk factor in individuals with prediabetes and type 2 diabetes (T2D). Curcumin, with its anti‐inflammatory and antioxidant properties, has emerged as a potential adjunct therapy, but its effect on blood pressure in this population…
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Artikel Jurnal
Circular RNAs in Diabetic Foot Ulcers: A Scoping Review of Clinical, Preclinical, and In Silico Evidence on Diagnostic and Therapeutic Potentials
ABSTRACT Background and Objective Diabetic foot ulcers (DFUs) involve chronic inflammation, impaired angiogenesis, oxidative stress, and disrupted fibroblast–keratinocyte interactions. Circular RNAs (circRNAs), a category of stable non‐coding RNAs, have become essential regulators of these…
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Artikel Jurnal
Tirzepatide and Cardiovascular Outcomes: A Narrative Review of Mechanisms, Efficacy and Implications for Heart Failure Management
ABSTRACT Background Tirzepatide, a dual GIP/GLP‐1 receptor agonist, offers a novel cardiometabolic strategy beyond glycemic control with important implications for heart failure care. By producing potent, sustained weight reduction and favourable changes in lipids, blood pressure, systemic…
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Artikel Jurnal
Diabetic Kidney Disease Progression Alleviated in Mice by ALKBH5‐Mediated UC‐MSCs‐Derived Exosomes That Inhibit TRAF6 m6A Modification and Promote M2 Macrophage Polarisation
ABSTRACT Background Diabetic kidney disease (DKD) is a major diabetes complication with limited treatment options. Exosomes (Exo) from umbilical cord mesenchymal stem cells (UC‐MSCs) have shown therapeutic promise. The role of alkylation repair homologue protein 5 (ALKBH5)‐modified UC‐MSCs Exo in…
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Artikel Jurnal
High‐Protein Diet Exacerbates Insulin Resistance via the JNK/IKKβ‐IRS‐1 Pathway
ABSTRACT Objective To investigate the effects of a high‐protein (HP) diet on insulin resistance in a type 2 diabetes (T2D) mouse model. Methods A high‐fat diet combined with streptozotocin (STZ, 25 mg/kg) was used to induce a T2D model. Fasting blood glucose levels > 7 mmol/L were considered…
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Artikel Jurnal
Impact of Preoperative Calcium and Magnesium Supplementation on Quality of Life and Hypocalcemia Post‐Thyroidectomy
ABSTRACT Objective Postoperative hypocalcemia and hypoparathyroidism are common complications after thyroidectomy, often impairing quality of life (QoL). This study investigates the impact of preoperative calcium and magnesium supplementation on postoperative QoL and hypocalcemia in patients…
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Artikel Jurnal
Sumac (Rhus coriaria L.) and Human Metabolic Health: A Systematic Review and Meta‐Analysis
ABSTRACT Background Rhus coriaria L. (Anacardiaceae), known as Sumac, is a commonly used spice, which is rich in various classes of phytochemicals including flavonoids, tannins, polyphenolic compounds, organic acids, and may be beneficial for cardiovascular disease risk factors. This comprehensive…
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Artikel Jurnal
The Effect of Aronia melanocarpa (Chokeberry) on Body Weight and Fasting Blood Sugar: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials
ABSTRACT Background Plant derivatives, particularly anthocyanin‐rich phytochemicals, have been shown to positively influence metabolic parameters. This study aimed to systematically review and meta‐analysis the effects of Aronia melanocarpa consumption on body weight and fasting blood sugar (FBS)…