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Biochemistry and Biophysics Reports
Scopus
ISSN 2405-5808 · Elsevier · 2.201 artikel di indeks
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Artikel Jurnal
Identification of potential biomarkers and therapeutic targets for liver cirrhosis based on Mendelian randomization and machine learning
Background: Liver cirrhosis(LC) represents the end stage of chronic liver disease, yet reliable molecular markers remain limited. This study aimed to uncover potential diagnostic biomarkers and therapeutic targets for LC. Methods: We integrated differential gene analysis from LC datasets in the…
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Artikel Jurnal
Molecular identification and phylogenetic analysis of marmots in the Xinjiang's Altai Mountains, a newly discovered plague focus of China
The Altai Mountains in Xinjiang have been recognized as a new plague focus in China since 2023. Although previous morphological studies suggested that marmots in this region belong to Marmota baibacina, this classification remained unconfirmed at the molecular level. In this study, 37 marmot…
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Loss of daily phase relations identified by multiomic analyses in acute pancreatitis
Acute pancreatitis (AP) is sudden inflammation of the pancreas which can cause organ failure and death, and with no targeted therapies in the clinic, there is an imperative to identify new potential avenues for therapeutics discovery. This exploratory study investigates the potential role of…
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Preimplantation genetic testing for polygenic diseases: A novel paradigm in embryo selection
Polygenic diseases are caused by a number of independently acting or interacting polymorphic genomic variants in conjunction with environmental factors, and show an increasing global prevalence, posing a significant threat to individual and public health. Given the limited curative prospects for…
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Artikel Jurnal
Directed evolution of Clec12a-binding peptides using mammalian-expressed recombinant protein
Clec12a is an immunoregulatory C-type lectin receptor expressed on dendritic cells as well as other myeloid cells, and involved in maintaining immune homeostasis. Unlike many other C-type lectin receptors that promote immune activation, Clec12a transmits inhibitory signals through an immunoreceptor…
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Artikel Jurnal
Dual-transferred atmospheric-pressure plasma jet modulates matrix metalloproteinase expression in breast cancer stem cells
Breast cancer stem cells (BCSCs) are a highly aggressive subpopulation, driving tumor initiation, metastasis, and therapeutic resistance, largely through matrix metalloproteinases (MMPs)–mediated extracellular matrix remodeling. Here, we introduce a dual-transferred atmospheric-pressure plasma jet…
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Artikel Jurnal
Preventive and inhibitory effects of Salacia on sustained contraction of vascular smooth muscle cells and characterization of the active compounds
Sustained contraction of vascular smooth muscles can abruptly restrict blood flow, leading to ischemia. While mild, prolonged contractions may cause dizziness and migraines, severe vasoconstriction (vasospasm) can result in cerebral or myocardial infarction and may be fatal…
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Artikel Jurnal
Human milk oligosaccharides promote synaptogenesis and neurite outgrowth in human cortical organoids
The first 1000 days of a child's life represent a critical window for brain development, during which nutrition exerts profound effects on the trajectories of neurodevelopment. Human Milk Oligosaccharides (HMOs), a major component of human milk, are largely indigestible by infants and are known to…
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Dynamic modulation of N6-methyladenosine by ionizing radiation in human cells
A cell's transcriptome is regulated through the integration of external and internal signals that activate intracellular signal pathways, epigenetic modifications and post-translational changes. Post-transcriptional regulation through RNA methylation has emerged as an important mechanism in cancer…
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EWSR1 as a regulatory target in hepatic stellate cell apoptosis and liver fibrosis therapy
Liver fibrosis is a progressive condition driven by hepatic stellate cell (HSC) activation and resistance to apoptosis, culminating in excessive extracellular matrix (ECM) accumulation and organ dysfunction. Current antifibrotic therapies remain limited, as most target broad pathways such as TGF-β…
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Artikel Jurnal
Mammalian evolution and human mutation burden in Rab GTPases
Rab GTPases are essential regulators of membrane trafficking with known roles in neurodegeneration, cancer progression and metastasis. While individually, Rabs have been extensively studied in disease and phylogenetic contexts, the overall evolutionary and mutation patterns that influence Rab…
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Crucial involvement of transforming growth factor beta (TGF-β)/Smad signaling regulation by miR-204-5p in cataract and posterior capsular opacification
Worldwide, cataracts remain the leading cause of irreversible blindness, primarily driven by age-related changes and free radical-mediated lens damage. Posterior capsular opacification (PCO) is a common complication following cataract surgery, arising from aberrant proliferation and…
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Artikel Jurnal
Clustering-based progressive alignment with fuzzy logic (CPA-FL)
Multiple sequence alignment (MSA) is a fundamental tool for identifying conserved regions and inferring molecular structure, function, and evolutionary relationships. Despite decades of progress, aligning large and evolutionarily diverse sequence sets remains computationally challenging and prone…
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Hyaluronan induces ERK activation with minimal transcriptomic changes in pancreatic α-cells
Type 1 diabetes (T1D) is driven by the immune-mediated destruction of pancreatic β-cells. While β-cells are selectively targeted and depleted in T1D, α-cells that secrete glucagon are relatively spared from this autoimmune attack. Hyaluronan (HA), a glycosaminoglycan component of the extracellular…
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Artikel Jurnal
Emodin inhibits breast tumorigenesis in the comorbidity of hyperlipidemia and associated with IL-17 suppression
Background: This study explored the interaction between breast cancer and the hyperlipidemia microenvironment, and assessed the anti-tumorigenic effects of the natural compound Emodin. Methods: The human cancer atlas and gene expression databases were used to identify links between breast cancer…
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Artikel Jurnal
Enhancing colorectal cancer diagnosis with the ferroptosis marker GPX4 and serum biomarkers: A retrospective analysis and machine learning approach
Background: Colorectal cancer (CRC) remains a significant global health burden characterized by high incidence and mortality. Although early diagnosis is crucial for improving prognosis, current screening methods are limited by insufficient sensitivity. Ferroptosis, an iron-dependent form of…
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Artikel Jurnal
A review of new developments in peripheral nerve regeneration
Peripheral nerve injury (PNI) is a significant health concern, affecting millions worldwide. Key neurotrophic factors, including nerve growth factor, brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor, have shown promise in facilitating neural regeneration…
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Artikel Jurnal
Capsaicin responses in Drosophila: Exploring the possibility of establishing a new Non-TRPV1 model
Capsaicin, the primary pungent compound in chili peppers, activates the heat-sensitive ion channel transient receptor potential vanilloid 1 (TRPV1) in mammals, eliciting the characteristic burning sensation. On the other hand, Drosophila melanogaster is a powerful invertebrate genetic model for…
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Artikel Jurnal
LncRNA GAS5 regulates osteogenic differentiation of human periodontal ligament stem cells through miR-23b-3p/STAT5B axis
Periodontal ligament stem cells (PDLSCs) play a crucial role in alveolar bone regeneration due to their inherent osteogenic differentiation capacity. However, the molecular mechanisms regulating PDLSC osteogenic differentiation remain incompletely understood. In this study, human PDLSCs were…
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Artikel Jurnal
Investigating the consequences of tape-stripping in ovalbumin-induced allergic mouse model: From physiology to gene regulation
Background: Food allergy is a growing global health concern, with increasing prevalence and significant impacts on patients quality of life. Epithelial barrier dysfunction, particularly through the skin-gut axis, has emerged as a critical factor in food allergy pathogenesis. However, the precise…
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