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Trends in cancer
Scopus
ISSN 2405-8025 · Elsevier BV · 21 articles in the index
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Gastric cancer immunosuppressive microenvironment heterogeneity: implications for therapy development
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Immune mechanisms of toxicity from checkpoint inhibitors
Immunotherapy has changed the treatment landscape for cancer over the past decade. Inhibitors of the immune checkpoint proteins cytotoxic T lymphocyte antigen (CTLA)-4, programmed death (PD)-1, and PD ligand 1 (PD-L1) can induce durable remissions in a subset of patients with metastatic disease…
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Challenges in glioblastoma research: focus on the tumor microenvironment
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Better together: circulating tumor cell clustering in metastatic cancer
Circulating tumor cells (CTCs) are vital components of liquid biopsies for diagnosis of residual cancer, monitoring of therapy response, and prognosis of recurrence. Scientific dogma focuses on metastasis mediated by single CTCs, but advancement of CTC detection technologies has elucidated…
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3D In Vitro Model (R)evolution: Unveiling Tumor–Stroma Interactions
The complex microenvironment in which malignant tumor cells grow is crucial for cancer progression. The physical and biochemical characteristics of this niche are involved in controlling cancer cell differentiation, proliferation, invasion, and metastasis. It is therefore essential to understand…
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Clinical Development of BRAF plus MEK Inhibitor Combinations
Genomic profiling shows that many solid tumors are characterized by specific driver aberrations, and this has expanded the therapeutic options for many patients. The mitogen-activated protein kinase (MAPK) pathway is a key cell signaling pathway involved in regulating cellular growth…
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Senescent Cells in Cancer Therapy: Friends or Foes?
Several cancer interventions induce DNA damage and promote senescence in cancer and nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors collectively termed the senescence-associated secretory phenotype (SASP). SASP factors are able to potentiate various aspects of…
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The Influence of Lung Microbiota on Lung Carcinogenesis, Immunity, and Immunotherapy
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The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View
The collection of microbes that live in and on the human body - the human microbiome - can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much…
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Targeting Glycosylation: A New Road for Cancer Drug Discovery
Cancer is a deadly disease that encompasses numerous cellular modifications. Among them, alterations in glycosylation are a proven reliable hallmark of cancer, with most biomarkers used in the clinic detecting cancer-associated glycans. Despite their clear potential as therapy targets, glycans have…