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Jurnal Respirasi
ISSN 2407-0831 · Universitas Airlangga · 281 articles in the index
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Journal Article
Decoding the Mechanistic Interplay of JAK/STAT and MAPK Signaling in the Pathogenesis of COPD: Crosstalk Dynamics and Multi-Target Therapeutic Frontiers
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascade constitutes an intracellular communication framework that is responsive to cytokines and growth factors, whereas the mitogen-activated protein kinase (MAPK) pathway represents a signaling network…
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Journal Article
Review of Pulmonary Sarcoidosis Progress into a Refractory Disease: Risk Factors, Biomarkers and Imaging as the Evaluation
Sarcoidosis is a multisystem, immune-mediated disorder of undetermined etiology, characterized by the formation of non-caseating granulomas. Pulmonary sarcoidosis exhibits highly variable clinical progression. Refractory pulmonary sarcoidosis (RPS), defined as disease unresponsive to standard…
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Journal Article
The Role of Artificial Intelligence in Enhancing Lung Cancer Diagnostic Accuracy: A Literature Review
Lung cancer remains the leading cause of cancer-related mortality worldwide, with particularly high incidence in Asia, including Indonesia. The stage at diagnosis is a key determinant of prognosis. Therefore, early and accurate detection is essential to improve survival and quality of life…
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Journal Article
Endobronchial Tuberculosis Mimicking Lung Malignancy: A Case Report
Introduction: Endobronchial tuberculosis (EBTB) is an infection of Mycobacterium tuberculosis (MTB) in the tracheobronchial tree. This case report aimed to describe the diagnostic challenge of endobronchial TB mimicking lung malignancy and to emphasize the role of bronchoscopy in establishing the…
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Journal Article
Chronic Cavitary Pulmonary Aspergillosis with Divergent Clinical Courses: A Case Series of Two Patients Presenting with Recurrent Hemoptysis
Introduction: Chronic pulmonary aspergillosis (CPA) is a progressive, potentially life-threatening fungal infection of the lungs. Its management is complicated by comorbidities, chronicity, and diagnostic uncertainty. While antifungal therapy remains the cornerstone of treatment, surgical…
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Journal Article
Dental Foreign Body in the Right Bronchi of Elderly Patients: A Case Report
Introduction: The aspiration of foreign bodies into the airway is rare in adults, except in the elderly with impaired consciousness or difficulty swallowing. Serious complications such as recurrent cough, infection, and pulmonary atelectasis are potentially life-threatening. Diagnosis is made based…
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Journal Article
Cigarette Smoking and Betel Nut Chewing Behavior among Junior High School Students in Rural Sorong, West Papua, Indonesia
Introduction: Smoking and other unhealthy behaviors, such as betel nut chewing, alcohol consumption, and vaping, are potential health problems in the eastern part of Indonesia. It is prevalent among young adolescents in Eastern Indonesia. Nevertheless, data regarding these are still rare…
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Journal Article
Prevalence of Methicillin-Resistant Staphylococcus aureus among Intensive Care Unit Healthcare Workers: A Single Center Study
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial infections, contributing to increased mortality, morbidity, and healthcare costs. Healthcare workers (HCWs) in intensive care units (ICUs) are at increased risk of MRSA colonization and may serve as…
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Journal Article
ROS1 Expression and Histopathological Grading in Non-Small Cell Lung Cancer Patients at Tertiary Hospitals in Medan, Indonesia
Introduction: Lung cancer remains the leading cause of cancer-related mortality worldwide, with most cases classified as non-small cell lung cancer (NSCLC). Genetic alterations in epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), Kirsten rat sarcoma viral oncogene homolog…
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Journal Article
Elevated Serum Levels of Isoprostane and Glutathione in Waste Landfill Workers
Introduction: Waste landfill workers are frequently exposed to air pollutants, bioaerosols, and heavy metals, which may induce oxidative stress. Biomarkers such as isoprostanes and glutathione can be used to assess oxidative stress and antioxidant responses associated with landfill exposure…
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Journal Article
Prevalence of Metabolic Disease in Patients with Chronic Obstructive Pulmonary Disease (COPD) at Universitas Airlangga Hospital, Surabaya, Indonesia
Introduction: Chronic obstructive pulmonary disease (COPD) is a major global health problem and remains one of the three leading causes of death worldwide. In addition to respiratory impairment, COPD is often associated with systemic inflammation that contributes to metabolic disorders such as…
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Journal Article
Utilization of MBD-MBS Questionnaire as a Screening Tool for Mouth Breathing Habits in Children 6-12 Years Old in Bandung, Indonesia
Introduction: Mouth breathing is one of the earliest manifestations of obstructive sleep apnea (OSA). Despite the availability of validated screening tools for early detection, their use remains limited in Bandung, Indonesia. This study examined the use of the mouth breathing in the daytime-mouth…
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Journal Article
The Effectiveness of Asthma Exercise in Improving Peak Expiratory Flow in Patients with Asthma
Introduction: The prevalence of asthma increases annually. In addition to pharmacological therapy, asthma management can also be achieved through non-pharmacological therapies, including physical activity such as jogging or exercise. Exercise for asthma is beneficial for strengthening respiratory…
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Journal Article
Potential Biomarkers and Inflammatory Modulation of Hyperbaric Oxygen Therapy in Long COVID: A Narrative Update
Introduction: Long coronavirus disease (COVID-19), also known as post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC), is characterized by persistent, often debilitating symptoms that extend beyond the acute phase of COVID-19. These manifestations are…
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Journal Article
Digital Technology in Improving Tuberculosis Treatment Adherence: A Systematic Review
Introduction: Indonesia ranks second globally in the number of tuberculosis (TB) cases. One strategy to eliminate TB is to use research and technology. The long duration of treatment may lead to non-adherence. Digital health interventions have become a promising option for monitoring treatment…
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Journal Article
Early Rehabilitation for the Prevention and Management of Pleural Empyema: A Narrative Review
Introduction: Parapneumonic effusions (PPE) can progress to pleural empyema (PE), a severe condition associated with increased morbidity and mortality. Pleural empyema impairs lung function due to pleural inflammation, fluid accumulation, and restricted diaphragm movement. Patients with severe PPE…
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Journal Article
Persistent Pneumothorax in Neurofibromatosis Type-1
Introduction: Neurofibromatosis type 1 (NF-1) is a rare autosomal dominant disorder. While typically recognized by its cutaneous features, pulmonary involvement, including apical cysts and basal interstitial fibrosis consistent with interstitial lung disease (ILD), can occur in up to 20% of…
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Journal Article
Endobronchial Tuberculosis Masquerading as a Lung Mass: A Rare and Challenging Diagnosis
Introduction: Endobronchial tuberculosis (EBTB) is a rare form of tracheobronchial infection by Mycobacterium tuberculosis (MTB). It is estimated to occur in 10-40% of patients with active pulmonary TB. It often presents atypically and mimics other diseases, particularly in asymptomatic…
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Journal Article
Massive Pleural Effusion Leads to the Revelation of Malignant Pleural Mesothelioma: A Case Report
Introduction: Malignant mesothelioma is a cancer that develops from the thin layer of tissue covering visceral organs (mesothelium). Up to 80% of malignant mesothelioma cases are caused by asbestos exposure. This case report describes a 56-year-old female with massive left pleural effusion caused…
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Journal Article
The Potential of Ethanol Extract Tamarillo (Solanum betaceum) on B-Cell Lymphoma 2 Expression in Mice (Mus musculus) Lungs Exposed to Lead Acetate
Introduction: Lead acetate, a toxic heavy metal compound, induces cellular and tissue injury primarily through oxidative stress. Exposure via inhalation or ingestion enables systemic absorption and distribution to target organs, particularly the lungs. One of the key anti-apoptotic proteins…