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Universa Medicina
ISSN 2407-2230 · Faculty of Medicine Trisakti University · 133 articles in the index
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Journal Article
Genetic counselling problems with parents of child with ROB der(21;21)(q10:q10) Down syndrome: a case report
Background Down syndrome (DS) is a genetic disorder caused by addition of a full or partial chromosome 21. The most common type of DS (90–95%) is pure trisomy 21; mosaicism occurs in 6–7%, and about 3–5% comprises translocation DS including Robertsonian translocation, which could be inherited from…
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Journal Article
Effect of using normal saline, alcohol and acetone on pain during removal of polyacrylate adhesive dressings in children aged 10–15 years: a pilot randomized controlled trial
Background Removing wound dressings containing polyacrylate adhesives can cause pain, especially in pediatric patients with more sensitive skin and lower pain thresholds. This study aimed to evaluate the effects of normal saline, alcohol, and acetone on pain during dressing removal in children and…
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Journal Article
Molecular progression of chronic rhinosinusitis: a pseudotime reconstruction of a transcriptomic dataset
Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease that is classified based on the presence of nasal polyps. However, whether CRS and nasal polyps represent discrete entities or a continuous progression remains unclear. Most studies have relied on cross-sectional…
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Journal Article
Clinical utility of artificial intelligence in prehospital emergency medical services : a systematic review and meta-analysis
Background The emergency medical services (EMS) sector presents substantial hurdles in providing excellent treatment while operating within limited resources. Artificial intelligence (AI) has significant potential in prehospital EMS, where rapid and accurate decision-making is essential. However, a…
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Journal Article
Maternal Trichomonas vaginalis as a risk factor of spontaneous preterm labour in Southwest Nigeria: a case-control study
Background Trichomonas vaginalis is a sexually transmitted protozoan infection associated with adverse pregnancy outcomes, including spontaneous preterm labour. The proposed mechanism involves genital tract inflammation, which may trigger cervical changes and uterine contractions. This study…
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Journal Article
Association between homicide and myocardial infarction mortality: a population-level analysis in Mexico from 2000 to 2019
Background Globally, violent deaths represent a serious public health issue, and Mexico has shown an increase in homicides. Exposure to violence has been linked to adverse mental and physical health outcomes, including cardiovascular disease. However, population-level evidence linking homicide…
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Journal Article
Trends of early-onset colorectal cancer biomarkers from 1985 to 2024 : a bibliometric analysis
Early-onset colorectal cancer (EOCRC) is increasingly recognized as a global public health concern. Biomarker research in EOCRC has expanded across hereditary, molecular, epigenetic, liquid biopsy, microbiome, and multi-omics domains, but the overall research landscape remains fragmented. This…
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Journal Article
Clinico-epidemiological profile of disorders of sex development at a tertiary referral hospital in South Kalimantan, Indonesia
Background Disorders of sex development (DSD) comprise a group of complex conditions that pose significant diagnostic and clinical issues. This study aimed to describe the clinical spectrum, temporal patterns, and geographical distribution of DSD cases at a tertiary referral hospital in South…
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Journal Article
Gamma-oryzanol as a potential intervention for normalizing insulin secretion and pancreatic β-cell function
The bioactive substance gamma-oryzanol (GO), which is mostly present in rice bran oil, has attracted a lot of interest due to its possible therapeutic application in metabolic conditions like diabetes mellitus. The effects of GO on insulin secretion and pancreatic β-cell function are examined in…
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Journal Article
Attitude towards telemedicine and e-health literacy among health sciences faculty students
Background Telemedicine is no longer a futuristic concept and is increasingly integrated into health care. The aim of this study was to determine the attitudes toward telemedicine in connection with e-Health literacy among students in a Faculty of Health Sciences. Methods This cross-sectional study…
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Journal Article
Knowledge of people with visual impairment about contraceptives: an exploratory study
Background Knowledge and information about contraceptives are key factors for the protection of reproductive health. Evidence from various parts of the world reveal that women with disabilities are facing widespread barriers in accessing public services. The aim of the study was to determine the…
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Journal Article
Female university students’ attitude toward fertility and childbearing in Vietnam
Background Population aging and declining fertility rates are emerging concerns worldwide. In Vietnam, fertility rates have decreased rapidly in recent years. Understanding young women’s attitudes toward fertility and childbearing is important for developing appropriate reproductive and population…
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Journal Article
Strengthening clinical microbiology laboratories and prevention programs: a call to action for better infection control
The coronavirus disease 2019 (COVID-19) pandemic has revealed severe vulnerabilities in the global clinical laboratory systems, especially in low- and middle-income countries, where diagnostic capacity is still poor. As the world emerges from the acute phase of the pandemic, antimicrobial…
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Journal Article
Targeting tumor associated macrophages to alternate cancer stem cells and tumor microenvironment milieu
Macrophages in the tumor microenvironment are involved in promoting cancer growth and enabling it to evade therapies. By acting as something like a tumor's "underground," these cells dampen down the "calls for help" that chemotherapy or radiotherapy might otherwise trigger. They also appear to…
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Journal Article
Dendrophthoe pentandra (Mango Mistletoe) leaves modulate steroidogenic acute regulatory protein, aromatase, and estrogen receptor expression in aged mice
BACKGROUND Ovarian aging is associated with impaired steroidogenesis and estrogen signaling, contributing to reproductive dysfunction. Dendrophthoe pentandra (Mango Mistletoe), a flavonoid-rich plant with antioxidant properties, has demonstrated anti-inflammatory and cytoprotective effects in…
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Journal Article
Transforming intracranial hemorrhage detection with artificial intelligence: advances in neuroimaging
Intracranial hemorrhage (ICH) represents a challenging neurological emergency, characterized by bleeding within the cranial vault. Timely intervention in this case is directly linked to reduced mortality and prevention of permanent sequelae. The interpretation of radiological examination for ICH is…
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Journal Article
Prevalence and risk factors of Entamoeba histolytica and Giardia lamblia infection among patients with gastrointestinal complaints
Background Intestinal parasitic infections remain a significant public health problem in developing regions, primarily driven by inadequate hygiene and sanitation standards. The most prevalent protozoan parasites causing gastrointestinal illness are Entamoeba histolytica and Giardia lamblia. This…
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Journal Article
The Effect of Nanoliposomal Curcumin (Cur-NLPs) Proliferation Rate with Cell Counting Kit 8 (CCK-8) and PI3K expression in cervical cancer HeLa cells
INTRODUCTION Cervical cancer is a major health problem in developing countries. Cisplatin therapy has limitations related to toxicity and drug resistance associated with activation of the PI3K/AKT/mTOR pathway. Curcumin has anticancer activity, but its bioavailability is low; therefore, it has been…
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Journal Article
Glucocorticoid-induced adrenal insufficiency after receiving intravenous methylprednisolone for Graves' ophthalmopathy: a case report
BACKGROUND Graves’ ophthalmopathy (GO) is the most common extrathyroidal manifestation of Graves’ disease and can significantly impair visual function and quality of life. High-dose intravenous methylprednisolone (IVMP) is recommended as first-line therapy for moderate-to-severe active GO due to…
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Journal Article
High neutrophil-to-lymphocyte ratio is not a risk factor of severe dengue infection in children
Background Dengue infection in children globally shows a significant increasing trend in incidence and remains a heavy public health burden. Dengue infection can progress rapidly to death, especially in children. The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory biomarker that represents…