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Pharmaceutical Sciences and Research
ISSN 2407-2354 · Universitas Indonesia · 200 articles in the index
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Journal Article
Current Update of Clinical Therapeutic Strategies for Colon-Targeted Delivery Systems
Oral colon-targeted drug delivery systems represent a significant advancement offering both systemic and local therapeutic effects for a range of intestinal diseases, including irritable bowel syndrome, inflammatory bowel disease, colonic bacterial infections, and colorectal cancer. These systems…
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Journal Article
Transdermal Delivery of Ketoprofen for Osteoarthritis Treatment and Management: A Literature Review on Current Progression
Arthritis, a diverse spectrum of joint disorders, is characterized by chronic pain and inflammation. Osteoarthritis (OA), the most prevalent form, leads to disabling pain, functional limitations, and reduced mobility. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for managing OA…
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Journal Article
Harnessing the Potential of Several Local Indonesian Tuber-derived Starches as Pharmaceutical Excipients
Starch is one of the widely required excipients in pharmaceutical dosage forms manufacturing. Indonesia’s rich biodiversity, encompassing tubers like arrowroot, taro beneng, porang, ganyong and yams, harbours the potential for novel starch excipient sources. These tubers provide starch variations…
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Journal Article
Challenges and Future Perspective of Gastroretentive Mucoadhesive Dosage Forms
Gastroretentive Mucoadhesive Dosage Form (GMDF) is one type of Gastroretentive Drug Delivery System (GRDDS) technology designed to exploit the adhesiveness of dosage forms in the gastric mucosa. This aims to increase drug residence time, enhance drug solubility and absorption, and ultimately…
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Journal Article
Physico-Chemical, Organoleptic, and Antioxidant Properties of Black Soybean Flour (Glycine soja (L.) Merrit) Flakes with the Addition of Bangle (Zingiber purpureum Roxb.)
Flakes are products that are generally made from cereals. In this study, we are interested to use black soybean (Glycine soja (L) Merrit) and bangle (Zingiber purpureum Roxb.) as flakes ingredients. Black soybeans have high antioxidant components, while bangle contains high antioxidant and fiber…
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Journal Article
Antioxidant Activities and Protective Effects of Shorea macrophylla Leaf and Bark Extracts
Shorea macrophylla, also known as the ‘Engkabang’ tree or Light Red Meranti, is renowned for its role in reforestation efforts. Despite lacking records of traditional use, the reported biological activities of other species within the Shorea genus spark curiosity about the potential biological…
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Journal Article
Application of PVP VA 64 and Poloxamer 188/407 in Solid Dispersion Technology for Improving Solubility of Valsartan
Valsartan, Biopharmaceutical Classification System (BCS) class II drug, exhibits pH-dependent solubility in the gastrointestinal tract, which increases at pH levels above 5. Its low solubility results in a bioavailability of only 23%, necessitating efforts to enhance it. This study aims to improve…
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Journal Article
Recent Updates on Dried Blood Spot and Volumetric Absorptive Microsampling as Microsampling Technique for Antiepileptic Drug Determination: A Systematic Review
Implementation of Therapeutic Drug Monitoring (TDM) can be useful for patients with uncontrolled seizures. This review article aims to collect and compare the recent development of bioanalytical methods for antiepileptic drugs using microsampling techniques, namely DBS (Dried Blood Spot) and VAMS…
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Journal Article
Antioxidant, Tyrosinase Inhibition Activity, and In Vitro SPF Evaluation of Pepino Fruit Extract (Solanum muricatum Aiton) in Different Solvent Types and Concentrations
Solvent is a key factor that affects the effectiveness of active compound extraction from plant materials (simplisia). This study aimed to determine the optimal type and concentration of solvent used in the extraction of pepino fruit based on the parameter of antioxidant and tyrosinase inhibition…
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Journal Article
Utilization of Spent Arabica Coffee Grounds as Raw Material for Activated Charcoal in Liquid Bath Soap Formulation
Arabica coffee (Coffea arabica) is one of the most popular coffees among Acehnese, an ethnic group from Aceh, Indonesia. The amount of coffee consumed is directly proportional to the amount of coffee waste produced. Spent coffee grounds are the residue obtained during the brewing process. Spent…
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Journal Article
Interaction between Fluoxetine and Risperidone and Its Association with Clinical Outcomes in Schizophrenic Patients
The concurrent use of fluoxetine and risperidone to treat schizophrenia may result in drug interactions. This study aims to analyse the clinical outcomes of fluoxetine-risperidone therapy and the possibility of their interaction in schizophrenic patients. The clinical outcomes are patient status at…
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Journal Article
Solid Dispersion Technology for Improving the Solubility of Antiviral Drugs
Most drugs, including antiviral drugs, show low solubility in water, which affects dissolution, bioavailability, and therapeutic effectiveness. Therefore, many antiviral drugs are given in very large doses. One of the efforts to overcome these problems is the application of solid dispersions in…
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Journal Article
Synthesis of Ferrous Fumarate from Indonesian Iron Sand and In Vivo Body Weight Gain Test in Rats
Iron deficiency anemia (IDA) is a health problem in Indonesia. Prevention and treatment of IDA is carried out by giving fortified foods and oral iron therapy. Both can use ferrous fumarate which is made with reacting bivalent iron and disodium fumarate. Bivalent iron can be obtained from iron sand…
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Journal Article
Beyond Use Date (BUD) Determination of Ambroxol Hydrochloride Syrup by High-Performance Liquid Chromatography – UV/VIS Detector
Ambroxol HCl is a mucolytic agent often used to treat respiratory disorders associated with excess mucus secretion. This study aims to determine the beyond-use date (BUD) of ambroxol HCl syrup on the market based on analysis of the decrease in drug content using High-Performance Liquid…
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Journal Article
Antioxidant Activities of RoJa Herbal Tea: Combination of Rosella Flower (Hibiscus sabdariffa L.) and Ginger Rhizome (Zingiber officinale Rosc.)
Herbal teas and plant-based medicines have been widely used worldwide for their therapeutic and healing qualities. Rosella (Hibiscus sabdariffa L.) has various benefits in preventing digestive problems, liver disease, fever, and others. Ginger (Zingiber officinale Rosc.) or known as jahe in…
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Journal Article
Exploring Rosella (Hibiscus sabdariffa L.) Calyx Extracts as Natural Dye and Antioxidants in Lip Cream Product: Formulation and Evaluation
Rosella, also known as Hibiscus sabdariffa L., is a plant that contains anthocyanin compounds in its calyx, which are known for their antioxidant properties. These compounds give the plant a captivating red color and can be used as natural dyes. This study aimed to exploit anthocyanins in rosella…
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Journal Article
Optimization of 3,4-Dimethoxychalcone and Rutin Containing Gel with Simplex Lattice Design and In Vitro-In Vivo Test as a Sunscreen
3,4-Dimethoxychalcone and rutin, a flavonoid that contains chromophore groups, can absorb UV light and thus can be developed as a sunscreen. The objective of this study was to determine the optimum formula of 3,4-dimethoxychalcone and rutin containing gel, evaluate its physical stability, and…
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Journal Article
Optimization of Lubrication and Compression Process Parameters of Vitamin C Film-Coated Caplets
Tablet production is a very intricate process influenced by numerous process variables or parameters. This study aimed to identify the critical processing variables that affect Critical Quality Attributes (CQAs) of vitamin C film-coated caplets utilizing a statistical experimental design. A…
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Journal Article
Individual and Combined Effect of Eudragit® RS 100 and Eudragit® RL 100 on Sustained Release Characteristics of Ropinirole HCl-loaded Microparticles
Ropinirole HCl is a non-ergoline dopamine agonist which is recommended for the treatment of both Parkinson’s disease and Restless Legs Syndrome (RLS). Its half-life is about 6 hours and it is metabolized in the liver primarily by CYP1A2. Its metabolites are water-soluble and rapidly excreted from…
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Journal Article
Molecular Docking Analysis of Acanthus ilicifolius Compounds Toward CUL4B-DDB1-AhR-ERα Complex Protein for Antiosteoporosis Discovery
Osteoporosis represents a significant global public health issue, particularly among the aging population. Its incidence reaches 18.3% of the total population, with the highest prevalence observed in elderly postmenopausal women. A key factor in osteoporosis is the decreased expression level of…