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Advances in Radiation Oncology
Scopus
ISSN 2452-1094 · Elsevier · 1,307 articles in the index
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Journal Article
Sexual Toxicity After Chemoradiation for Anal Cancer Among Men Who Have Sex With Men: A Mixed-Methods Analysis
Purpose: Chemoradiation (CRT) is the standard of treatment for localized anal squamous cell carcinoma (SCCA). Although cure rates are high, acute and late toxicities are common. There are increasing published data regarding vaginal stenosis and erectile dysfunction; however, the nature and impact…
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Journal Article
Early Clinical Outcomes and Local Control Following Spine Stereotactic Proton Ablative Radiation Therapy
Purpose: To evaluate the local control (LC) outcomes and safety profile of stereotactic proton ablative radiation therapy (SPAR) for spine metastases in a highly selected patient population, with emphasis on reirradiation cases. Methods and Materials: We retrospectively reviewed all patients who…
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Journal Article
Adaptive Radiation Therapy in the 0-7-21 Regimen: A Retrospective Study of Tumor Volumetric Response
Purpose: A hypofractionated palliative radiation regimen referred to as “0-7-21,” which involves 1500 to 2400 cGy prescribed in 3 fractions delivered over 3 weeks (ie, days 0, 7, and 21), has been well documented in literature as an effective way to alleviate symptoms in solid malignancies with…
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Journal Article
Radiation Therapy Infrastructure, Social Vulnerability, and Insurance Architecture Predict Timely Postoperative Radiation Therapy After Brain Tumor Craniotomy
Purpose: Timely initiation of radiation therapy (RT) following craniotomy for malignant brain tumors is associated with better clinical outcomes. Despite guideline recommendations and best practices, the timely initiation of postoperative RT remains suboptimal. Our objective was to evaluate how…
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Journal Article
The Impacts of FLASH Radiation Therapy and Conventional Radiation Therapy on the Cognitive Abilities of Mice
Purpose: Preclinical studies have demonstrated that FLASH radiation therapy (RT) delivered at ultrahigh-dose rates exerts a preferential normal tissue-sparing effect. This study aimed to delineate the disparities in delayed cognitive function and biological outcomes of whole-brain irradiation in…
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Journal Article
Circulating Tumor DNA Predicts Response After Definitive Radiation Therapy for Merkel Cell Carcinoma
Purpose: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with a high recurrence rate. Circulating tumor DNA (ctDNA) assays are increasingly used to assess treatment response and detect recurrence. This study evaluated the value of ctDNA levels in MCC patients treated with definitive…
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Journal Article
Efficacy and Toxicity of Simultaneous Modulated Accelerated Radiation Therapy (SMART) in Intermediate- and High-Risk Oropharyngeal Carcinoma
Purpose: Hypofractionation has become part of the standard of care for many disease sites but not for head/neck cancers due to concerns about toxicity. However, this may change as evidence emerges. To assess the tolerability and efficacy of moderate hypofractionation, we conducted a study on…
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Journal Article
Impact of a Dedicated Inpatient Radiation Oncology Consult Service on Goal-Concordant Care
Purpose: Radiation therapy has an increasing role in the management of metastatic cancers. Integrating radiation with surgical and systemic approaches is complex, and inappropriate management can lead to prolonged hospitalizations inconsistent with palliative goals. An inpatient radiation oncology…
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Journal Article
Reduced-Dose Hypofractionated Radiation Therapy (3 Gy × 3 Fractions) for Indolent Non-Hodgkin’s lymphoma (POSEIDON): A Multisite Phase 2 Randomized Trial Protocol
Indolent non-Hodgkin’s lymphoma, including follicular and marginal zone lymphoma, is highly radiosensitive, with radiation therapy (RT) serving as an effective treatment. Although standard RT doses (24 Gy in 12 fractions) provide excellent disease control, they are associated with toxicity…
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Journal Article
Progress in Shortening Treatment Courses for Bone Metastases in a Statewide Quality Consortium
Purpose: A large body of research has studied various fractionation regimens for radiation therapy (RT) targeting bone metastases, with evidence that courses of 5 or fewer fractions are isoeffective compared with longer courses. We analyzed practice patterns within a statewide quality consortium…
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Journal Article
Growth Hormone Pathway as a Prognostic and Therapeutic Biomarker in Patients With Unresectable Hepatocellular Carcinoma Treated With Radiation Therapy
Purpose: Radiation therapy (RT) has emerged as an effective local therapy option for patients with unresectable hepatocellular carcinoma (HCC) and is associated with improved overall survival (OS). However, some patients still have poor outcomes after RT, and biomarkers are needed to stratify…
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Journal Article
Relative Biological Effectiveness of Carbon Ion Versus Photon Radiation Therapy for Acute Radiation-Induced Esophagitis in Locally Advanced Non-small Cell Lung Cancer Derived From Normal Tissue Complication Probability Modeling
Purpose: This study aimed to evaluate the relative biological effectiveness (RBE) of carbon-ion radiation therapy (CIRT) versus photon radiation therapy for acute radiation-induced esophagitis (ARIE) in patients with locally advanced non-small cell lung cancer, based on TD₅₀ derived from normal…
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Journal Article
Optical Flow-Guided Analysis of Intrafractional Anatomical Variations in Pancreatic Tumors and Organs at Risk During Magnetic Resonance-Guided Adaptive Radiation Therapy Under Abdominal Compression
Purpose: This study aimed to investigate intrafractional anatomic variations in pancreatic tumors and organs at risk (OARs) during magnetic resonance-guided adaptive radiation therapy (MRgART) using optical flow calculations. Methods and Materials: This study included 732,612 magnetic resonance…
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Journal Article
Clinical Implementation of Simulation-Free Palliative Radiation Therapy: Consensus Recommendations From a Modified Delphi Study
Purpose: Simulation-free radiation therapy (sim-free RT) uses diagnostic computed tomography scans in place of dedicated computed tomography simulations for treatment planning, potentially expediting palliative radiation therapy (PRT) while optimizing resource utilization. Broader adoption has been…
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Journal Article
Myeloablative Total Body Irradiation With Volumetric Modulated Arc Therapy for Children—a Single Center Experience
Purpose: Total body irradiation (TBI) is a critical component of conditioning therapy prior to allogeneic hematopoietic stem cell transplantation in pediatric acute lymphoblastic leukemia. Our institution implemented volumetric modulated arc therapy-TBI (VMAT-TBI) in 2023, aiming to improve target…
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Journal Article
Safety and Efficacy of External Beam Radiation Therapy in Hepatocellular Carcinoma Patients Previously Treated With Yttrium 90 Transarterial Radioembolization
Purpose: Data on the safety and efficacy of external beam radiation therapy (EBRT) after yttrium 90 transarterial radioembolization (TARE) for hepatocellular carcinoma (HCC) are limited. We report our experience using EBRT to treat HCC patients previously treated with TARE. Methods and Materials…
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Journal Article
Utilization and Safety of Concurrent Use of Abemaciclib and Radiation Therapy Among Patients With HR+, HER2− Metastatic Breast Cancer in the Real-World Setting
Purpose: Real-world data on tolerability of concurrent radiation therapy (RT) and abemaciclib are limited. This study described real-world utilization and safety of concurrent RT and abemaciclib in patients with hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative…
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Journal Article
Outcomes of Adjuvant Radiation Therapy in Penile Cancer
Purpose: This study evaluates the long-term outcomes of adjuvant radiation therapy (RT) in patients with penile cancer treated over 14 years. Methods and Materials: In this retrospective cohort study, patients with squamous cell carcinoma of the penis who underwent surgery followed by adjuvant RT…
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