2.926 hasil
Menampilkan 1–20 · 0,37 detik · RSS
Bioactive Materials
Scopus
ISSN 2452-199X · KeAi Communications Co., Ltd. · 2.926 artikel di indeks
-
Artikel Jurnal
Ultrasound-responsive nanotherapy promotes axonal regeneration after SCI via reactivating CREB/miR-129-5p signaling
Spinal cord injury (SCI) remains a devastating neurological disorder with few effective therapeutic interventions due to the poor intrinsic regenerative capacity of adult central nervous system neurons. Here, we identified miR-129-5p as a downstream effector of cAMP-response element binding protein…
-
Artikel Jurnal
Engineered probiotics couple photothermal cuproptosis with biomechanical disruption and immune activation
Living bacterial therapeutics face limitations from poor surface functionalization and a hostile tumor microenvironment. Here, we engineer EPACS (EcN@PDA/Au–CuS) by coating E. coli Nissle 1917 with polydopamine, which acts as an adhesive interfacial platform to direct the uniform in situ growth of…
-
Artikel Jurnal
In situ bioactive nanocoating enables transocular delivery of permeable drug for dual-location intervention of ocular surface and fundus disorders
The concurrency of ocular surface and fundus disorders is prevalent, posing a major threat to vision and quality of life. However, current therapies are difficult to simultaneously manage these coexisting symptoms. Here, we report a dual-location intervention strategy by in situ forming a permeable…
-
Artikel Jurnal
Calcium dysregulation in synergy with sonodynamic therapy via medroxyprogesterone-targeted and ROS-responsive nanoparticles for endometrial cancer
Effective therapies that enable precise drug delivery and integrated monitoring are urgently needed for fertility-sparing management of endometrial cancer (EC). Although calcium channel blockers (CCBs) exhibit anti-proliferative potential in EC, their poor tumor selectivity and systemic toxicity…
-
Artikel Jurnal
An ultrasound-responsive hydrogel with piezoelectric-enhanced bioelectric-vesicular coupling alleviates mitochondrial dysfunction and inflammation for osteoarthritis therapy
Osteoarthritis (OA) is a degenerative whole-joint disease characterized by interconnected pathological processes, including mitochondrial dysfunction, inflammatory microenvironment dysregulation, extracellular matrix (ECM) degradation, and aberrant subchondral bone remodeling. However, biological…
-
Artikel Jurnal
Aptamer-functionalized EGCG nanocarrier for neutrophil-targeted AKBA delivery promotes anxiety-related fracture healing
Anxiety is clinically associated with impaired fracture healing, but the underlying immunological mechanism remains unclear, and no targeted therapy is available. In a mouse model of chronic restraint stress (CRS)-induced anxiety with femoral fracture, we observed expansion of TGFβ1 + CCR5 +…
-
Artikel Jurnal
Matrix nanoalignment programs macrophage vesicular immunity through TRPV2 mechanogating
The extracellular matrix (ECM) undergoes extensive architectural remodeling during tumor progression, generating nanoscale alignment cues that profoundly influence behaviors of immune cells. However, whether ECM nanoarchitecture directly programs their immune secretory functions remains poorly…
-
Artikel Jurnal
Micellar LYTAC-engineered bionic coatings abrogate RANK-dependent osteocatabolism and boost fibrillogenesis-mimetic mineral accretion for empowering osteoporotic osseointegration
Patients with osteoporosis are highly susceptible to fractures that often require implant fixation and stabilization. However, excessive osteoclast activity under osteoporotic conditions accelerates bone resorption at the bone-implant interface, severely compromising implant osseointegration…
-
Artikel Jurnal
Targeted inhibition of inflammatory liver macrophages with a multifunctional nanoparticle ameliorates metabolic dysfunction–associated steatohepatitis
Despite metabolic dysfunction–associated steatohepatitis (MASH) being a significant global health concern, there are few effective ways to prevent or treat MASH. Evidence from preclinical and clinical studies suggests that inflammatory polarization of Kupffer cells (KCs) and infiltration of…
-
Artikel Jurnal
A bioactivity-enhanced thermosensitive amnion-derived hydrogel with sustained IGF-1 release: A multitargeted and efficient strategy for corneal injury repair
Corneal alkali burn (CAB) remains difficult to treat because rapid tear clearance limits topical drug exposure, while the injured cornea develops a complex microenvironment involving inflammation, neovascularization, fibrosis, epithelial barrier loss, and impaired nerve repair. Here, we developed a…
-
Artikel Jurnal
A transferrin receptor-targeted liposome for iron metabolism regulation-augmented photodynamic therapy in glioblastoma
The clinical standard treatments for glioblastoma (GBM) present a therapeutic challenge of high recurrence. 5-aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) offers a promising alternative owing to the selective biosynthesis of protoporphyrin IX (PpIX) in tumor mitochondria with…
-
Artikel Jurnal
Antifibrotic hydrogel strategies for scarless tissue regeneration: mechanisms, design, and application
Tissue repair is a highly coordinated process, yet dysregulated fibrosis often diverts healing toward scar formation, resulting in permanent structural and functional impairment. Achieving scarless regeneration requires precise modulation of the wound microenvironment to support functional tissue…
-
Artikel Jurnal
Dynamic coordination engineering of gallium biomaterials: A biological accessibility framework for therapeutic biofunction
Gallium (Ga)-based biomaterials have emerged as versatile therapeutic platforms owing to the iron-mimicking properties and broad biological activities of gallium. Coordination engineering regulates Ga speciation, stability, transport, and therapeutic activation; however, optimizing individual…
-
Artikel Jurnal
A designable twist-densification route to bioactive collagen hydrogel yarns approaching tendon-like mechanics
Reconstituted collagen hydrogels offer the bioactivity that load-bearing tissue engineering requires, but their Pascal to low-kPa moduli have confined them to non-structural roles, and the synthetic and hybrid strategies that close the mechanical gap typically forfeit that bioactivity. We show that…
-
Artikel Jurnal
Click chemistry-modified cardiomyocytes enhance cardiac contractility and prevent remodeling in ischemia-reperfusion injured hearts
One of the challenges in cardiac cell therapy using cardiomyocytes derived from human pluripotent stem cells (hPSC-CMs) is their poor engraftment and survival rate in infarcted tissues. Click chemistry and lipid insertion are simple methods for modifying the surface of hPSC-CMs with a collagen…
-
Artikel Jurnal
Zinc silicate microspheres-mediated bacterial metabolic interference and microenvironment remodeling for chronic wound repair
Chronic wounds have presented a significant clinical challenge due to persistent infection, uncontrolled inflammation, and impaired tissue regeneration. Existing therapeutic platforms have failed to integrate these critical aspects into a single, cohesive strategy. To address this, a novel…
-
Artikel Jurnal
Engineering ovarian asymmetric mechanical niches in a dual-layer microcavity array enhances mouse secondary follicle development and oocyte competence
With global population aging and declining fertility rates, the preservation of reproductive health has become an important biomedical challenge. In vitro follicle culture, especially secondary follicle culture, represents a promising strategy for advancing fertility preservation research; however…
-
Artikel Jurnal
A sequentially activated afterglow probe for AND-gated imaging of alpha-fetoprotein in hepatocellular carcinoma
Alpha-fetoprotein (AFP) plays multiple roles in hepatocellular carcinoma (HCC), driving tumor progression and immune evasion. However, clinical measurement of serum AFP levels often fails to reflect intratumoral AFP expression, especially for early-stage or well-differentiated HCC. Current imaging…
-
Artikel Jurnal
Hydrogen releasing biomaterials for bone regeneration: mechanisms, design strategies, and applications
Complex bone defects remain major clinical challenges due to their multifaceted pathological microenvironment. In recent years, hydrogen (H2) therapy has emerged as a rapidly developing strategy for bone repair, leveraging its redox-regulatory and other microenvironment-modulating effects. However…
-
Artikel Jurnal
A universal consuming endogenous H2S strategy using bismuth-metal-organic nanocapsule networks for overcoming osteosarcoma cisplatin resistance
Osteosarcoma (OS), the most common primary bone malignancy in adolescents, faces limited treatment options and high chemoresistance rates. Hydrogen sulfide (H2S), an endogenously produced gaseous signaling molecule that regulates cellular redox homeostasis, promotes chemoresistance in multiple…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.