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JACC: Basic to Translational Science
Scopus
ISSN 2452-302X · Elsevier · 1.066 artikel di indeks
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Artikel Jurnal
ICG-001 Provides Cardioprotection Against Doxorubicin-Induced Cardiotoxicity and Enhances Cancer Cytotoxicity
Summary: Doxorubicin is effective against cancer but can cause doxorubicin-induced cardiotoxicity (DCT). Drug discovery efforts against DCT are hampered by the need to balance cardioprotection and cancer control. This study demonstrates that ICG-001 suppressed DCT in patient-derived human induced…
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Artikel Jurnal
Animal Models in Biomedical Research
From early experimental physiology to modern mouse genetics, animal models have been central to the advancement of biomedical knowledge, enabling mechanistic insights into human disease and driving the development of transformative therapies. Animal model investigations have generated most of the…
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Artikel Jurnal
Emerging Role of Tet2 in the Regulation of Vascular Smooth Muscle Cell Identity During Arterial Calcification
Corresponding Authors:
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Artikel Jurnal
Immune Unresponsiveness to Cardiopulmonary Bypass Is Associated With Unfavorable Outcome in Infants Requiring Cardiac Surgery
Summary: Cardiopulmonary bypass (CPB) induces a complex immune response which can lead to complications after pediatric cardiac surgery. We hypothesized that analyzing the whole blood transcriptomic response after cardiac surgery with or without CPB in children would provide new insights into the…
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Artikel Jurnal
Myosin Modulator Aficamten Inhibits Force by Altering Myosin’s Biochemical Activity Without Changing Thick Filament Structure
Summary: We investigated the effects of aficamten on cardiac muscle structure, biochemical activity, and contractile function. Aficamten does not structurally sequester myosin heads along the thick filament. It inhibits ATPase activity by decreasing myosin ATPase cycling kinetics, with the…
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Artikel Jurnal
Pharmacological Enhancement of Integrated Stress Response Confers Protection in Calcific Aortic Valve Disease
Summary: Previous studies have shown that Nox4 activates eIF2α/ATF4 signaling during the integrated stress response (ISR) and protects heart injury. However, their roles in calcific aortic valve disease (CAVD) remain unclear. Here, we show that both ATF4 and Nox4 are up-regulated in porcine aortic…
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Artikel Jurnal
The Role of Sphingolipids in Myocardial Recovery Mediated by Mechanical Unloading and Circulatory Support
Summary: Myocardial recovery after left ventricular assist device (LVAD) support is a critical phenomenon that allows advanced heart failure patients to retain their native heart. We quantified targeted sphingolipids in serum and cardiac tissue of patients who exhibited recovery post-LVAD. Our…
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Artikel Jurnal
Epigenetic Reprogramming via TET2 Prevents Medial Calcification and Restores Vascular Smooth Muscle Cell Identity
Summary: Vascular calcification arises from the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and is a hallmark of many cardiovascular pathologies. This study identifies Tet2, a DNA demethylase, as a critical epigenetic regulator that prevents this phenotypic switch…
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Artikel Jurnal
Estrogen Influences Human Microvascular Endothelial Function Via Sex-Specific Regulation of Sphingolipids
Summary: Microvascular endothelial dysfunction strongly predicts poor cardiovascular outcomes, and recent studies have indicated that chronic estrogen treatment promotes endothelial dysfunction in isolated human microvessels. Here, using a translational approach, we demonstrate that sphingolipids…
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Artikel Jurnal
HDL Regulates TGFβ-Receptor Lipid Raft Partitioning, Restoring Contractile Features of Cholesterol-Loaded Vascular Smooth Muscle Cells
Summary: Many cells identified as macrophage-like in human and mouse atherosclerotic plaques are thought to be of vascular smooth muscle cell (VSMC) origin. We identified cholesterol-mediated down-regulation of TGFβ signaling in vitro in human (h)VSMCs by localization of TGFβ receptors in membrane…
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Artikel Jurnal
Dysfunction in Ankyrin-B Disrupts Heart Rate Regulation by Altering the Membrane Abundance of GIRK Channels
Summary: Ankyrin-B (AnkB), encoded by ANK2 , is essential for ion channel localization in the heart. We investigated its role in regulating sinoatrial node (SAN) responses to autonomic input. AnkB-haploinsufficient (AnkB + / − ) mice showed baseline bradycardia, heightened SAN response to…
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Artikel Jurnal
Rates of Lipoprotein(a) Oxidation Accelerate at Elevated Levels and Attenuate With Atorvastatin Active Metabolites Compared With Other Statins
Summary: Lipoprotein(a) [Lp(a)] levels are associated with increased cardiovascular risk, possibly linked to its oxidized phospholipid content that may accelerate lipoprotein oxidation. Attenuating this process could reduce Lp(a) atherogenicity. Atorvastatin is metabolized into 2 hydroxylated…
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Artikel Jurnal
An Estrogen–IL-33 Circuit in Aortic Fibroblasts Underlies Sex Differences in Tregs in Abdominal Aortic Aneurysm
Summary: Regulatory T cells (Tregs) are key components of the vascular immune microenvironment in abdominal aortic aneurysm (AAA), but their sexual dimorphism and underlying mechanisms remain unclear. This study aimed to characterize Treg sex dimorphism in AAA and delineate the governing hormonal…
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Artikel Jurnal
The Role of Cardiac Fibrosis and Fibroblast Activation in Amyloid Light Chain (AL) Amyloidosis
Summary: Recent studies suggest that interactions between collagen and amyloid fibril may influence amyloid formation, matrix remodeling, and disease progression in cardiac amyloid light chain (AL) amyloidosis. However, the precise pathophysiological mechanisms underlying fibrosis remain largely…
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