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Journal of Oncological Sciences
Scopus
ISSN 2452-3364 · Turkish Society of Oncology · 216 artikel di indeks
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Artikel Jurnal
Trends in Overall Survival and Associated Factors in Metastatic Rectal and Rectosigmoid Cancer: A SEER-based Cohort Study (2000-2022)
Objective: Metastatic rectal and rectosigmoid cancers remain associated with poor prognosis despite advances in systemic therapy. Although outcomes in metastatic colorectal cancer have improved overall, population-level survival trends specific to rectal cancer and their evolution across calendar…
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Artikel Jurnal
Predictive Factors for Residual High-grade Cervical Intraepithelial Lesions or Carcinoma on Final Pathology in Patients with Positive Surgical Margins after Cervical Conization and Endocervical Curettage
Objective: To evaluate the presence of residual preinvasive or invasive cervical disease after re-conization or hysterectomy in women with positive surgical margins following excisional treatment for high-grade squamous intraepithelial lesions (HSIL), and to identify pathological factors that may…
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Artikel Jurnal
Dual ALK/ROS1 Positivity in Lung Adenocarcinoma: A Case of Complete Response to Lorlatinib
Objective: Anaplastic lymphoma kinase (ALK) and ROS proto-oncogene 1 (ROS1) rearrangements are unique, mutually exclusive mutations that drive non-small cell lung cancer. Concurrent immunohistochemical positivity for both markers is exceedingly rare and may lead to diagnostic and therapeutic…
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Artikel Jurnal
Fourteen Years of Continuous Erlotinib Therapy in EGFR-mutant NSCLC: A Case Report of Isolated Cranial Progression Managed with Local Treatment
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly improved outcomes in EGFR-mutant non-small cell lung cancer. However, prolonged use beyond 10 years, particularly in cases of isolated central nervous system (CNS) progression, has rarely been reported. We report…
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Artikel Jurnal
Pretreatment Hemoglobin, Albumin, Lymphocyte, and Platelet Score Predicts Pathological Response and Postoperative Pathological Findings in Locally Advanced Gastric Cancer
Objective: The hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been extensively studied as a prognostic biomarker in various malignancies; however, its predictive value for pathological response to neoadjuvant chemotherapy remains unclear. This study aimed to evaluate the association…
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Artikel Jurnal
Prognostic Value of Inflammation-based Biomarkers in Patients with De Novo Metastatic Biliary Tract Cancer
Objective: Biliary tract cancers (BTCs) are highly aggressive malignancies associated with poor clinical outcomes; metastatic disease is already present at diagnosis in many patients. We investigated whether baseline inflammation-based biomarkers could provide prognostic information in patients…
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Artikel Jurnal
Clinical Predictors of Progression-free Survival in Patients with Metastatic Castration-resistant Prostate Cancer Treated with Lu-177 PSMA: A Real-world Study
Objective: Accurate pretreatment risk assessment remains an important challenge for patients with metastatic castration-resistant prostate cancer (mCRPC) undergoing lutetium- 177-labeled prostate-specific membrane antigen (Lu-177 PSMA) radioligand therapy, highlighting the need for reliable…
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Artikel Jurnal
The Prognostic Value of Pretreatment Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Systemic Immune-inflammation Index on Survival Outcomes in Non-metastatic Breast Cancer: A Retrospective Cohort Study
Objective: Systemic inflammatory response contributes to tumor progression and may influence survival outcomes in breast cancer. Blood-based inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII)…
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Artikel Jurnal
Effect of Prognostic Nutritional Index and Systemic Immune-inflammation Index Changes on Progression-free Survival in Patients Treated with CDK4/6 Inhibitors and Letrozole
Objective: CDK4/6 inhibitors are the standard of care for metastatic hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer. Markers for predicting prognosis and survival during follow-up of these patients are not yet available. Therefore, this…
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Artikel Jurnal
Comparative Efficacy of Second-line Anti-VEGF Continuation and Anti-EGFR Switch Strategies in RAS Wild-type Metastatic Colorectal Cancer Patients Progressing on First-line Anti-VEGF Therapy: A Retrospective Single-center Study
Objective: The optimal selection of second-line biological therapy remains unclear in patients with RAS wild-type metastatic colorectal cancer (mCRC) who develop disease progression following first-line anti-vascular endothelial growth factor (VEGF)-based treatment. This study aimed to compare the…
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Artikel Jurnal
Real-world Outcomes of Second-line Irinotecan Plus Bevacizumab in Recurrent High-grade Gliomas: A Single-center Retrospective Study
Objective: High-grade gliomas (HGGs), particularly glioblastoma, remain among the most aggressive primary central nervous system malignancies. Despite standard treatment consisting of maximal safe resection followed by radiotherapy with concurrent and adjuvant temozolomide, disease recurrence is…
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Artikel Jurnal
Perioperative Nivolumab Combined with Neoadjuvant Chemotherapy in Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma
Objective: The exact role of nivolumab in the perioperative systemic treatment of locally advanced-gastric/gastroesophageal junction (LA-G/GEJ) adenocarcinoma remains unclear. This study aimed to evaluate the real-world effectiveness and safety of perioperative nivolumab in patients with LA-G/GEJ…
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Artikel Jurnal
Clinicopathological Correlates of High Stromal Tumor-infiltrating Lymphocytes in Luminal Breast Cancer: A Real-world Study
Objective: The prognostic role of stromal tumor-infiltrating lymphocytes (sTIL) is well recognized in triple-negative and human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC), but their meaning in hormone receptor-positive, HER2-negative tumors is still debated. In luminal…
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Artikel Jurnal
Pathological Response and Survival Outcomes Following Neoadjuvant Chemotherapy in HR+/HER2- Breast Cancer: Real-world Experience
Objective: Hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer (BC) is the most common subtype but shows limited sensitivity to neoadjuvant chemotherapy (NAC), and its clinical benefit remains controversial. This study evaluated clinicopathological…
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Artikel Jurnal
The Impact of KRAS Mutation on Treatment Response and Survival in Patients with Metastatic Lung Adenocarcinoma Receiving First-line Systemic Therapy
Objective: The prognostic and predictive significance of kirsten rat sarcoma viral oncogene homologue (KRAS) mutations in metastatic non-small cell lung cancer remains controversial, particularly in the immunotherapy era. Most previous studies compared KRAS-mutant tumors with heterogeneous KRAS…
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Artikel Jurnal
Immunohistochemical Expression of EZH2 and INI-1 in Hepatocellular Carcinoma: Prognostic Significance in a Retrospective Cohort Study
Objective: Enhancer of zeste homologue 2 (EZH2) serves as the enzymatic component of polycomb repressive complex 2, while SMARCB1/INI-1 is an essential subunit of the SWI/SNF chromatin remodeling complex; both function as epigenetic regulators with proposed roles in hepatocarcinogenesis. This study…
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Artikel Jurnal
Clinicopathologic Features and Survival Outcomes in Women Aged 80 Years or Older with Advanced Ovarian Cancer
Objective: Women aged ≥80 years with ovarian cancer (OC) are significantly underrepresented in clinical trials, and their optimal management remains poorly defined. This study aimed to evaluate clinicopathologic characteristics and survival outcomes in this understudied population. Material and…
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Artikel Jurnal
Evaluation of Age-related Clinical and Molecular Characteristics in a Single-center Real-world Breast Cancer Cohort
Objective: Breast cancer exhibits biological heterogeneity that varies across age groups and influences treatment decisions. This study aimed to evaluate age-related differences in biomarker profiles, surrogate molecular subtypes, and treatment patterns in a single-center real-world breast cancer…
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Artikel Jurnal
Prognostic Significance of Postoperative Edema in Surgically Treated Non-glioblastoma Diffuse Glioma
Objective: Tumor-associated edema has been implicated as a marker of aggressive tumor biology in gliomas, yet most existing evidence is derived from preoperative imaging and glioblastoma-focused cohorts. The prognostic significance of postoperative edema in non-glioblastoma diffuse gliomas remains…
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Artikel Jurnal
The Effect of Adjuvant Treatment Preferences on Survival in Elderly Patients (≥65 Years) with Early-stage Breast Cancer
Objective: The optimal management of early-stage breast cancer in elderly patients remains challenging due to age-related comorbidities, limited life expectancy, and underrepresentation in clinical trials. This study aimed to evaluate the impact of adjuvant treatment preferences on survival…