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Non-coding RNA Research
Scopus
ISSN 2468-0540 · KeAi Communications Co., Ltd. · 511 artikel di indeks
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Artikel Jurnal
Integrative analysis of tissue and circulating miRNAs as biomarkers for progression and survival in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with limited biomarkers available for early diagnosis and risk stratification. In this study, we performed an integrative analysis of tissue and circulating microRNA (miRNA) expression profiles to identify candidates…
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miR-6850 drives phenotypic changes and signaling in high grade serous ovarian cancer
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression, and their dysregulation is closely linked to cancer development. Ovarian cancer (OC), particularly the high-grade serous ovarian carcinoma (HGSOC) subtype, is the most lethal gynecological malignancy, primarily due to…
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Keratinocyte-specific long non-coding RNA NR037661 controls alternative splicing of ANGPTL4 to induce keratinocyte differentiation
Background: Aberrant differentiation of keratinocytes has been implicated in various skin diseases. However, the impact of lncRNA on keratinocyte differentiation and RNA alternative splicing remains poorly understood. The primary aim of this study was to delineate the landscape of differentially…
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LncRNA expression in prostate cancer: From in silico analysis to urinary EV-based liquid biopsy for prognosis
Prostate cancer (PCa) is the most frequently diagnosed malignancy among men and remains a leading cause of cancer-related death. Despite the widespread use of diagnostic tools such as PSA testing and Gleason scoring, these methods often fall short in accurately predicting tumor progression…
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MiR-21 modulates P.g-LPS induced apoptosis and inflammatory response in HUVECs via NF-κB/iNOS/NO pathway by targeting PDCD4
Background: Porphyromonas gingivalis lipopolysaccharide (P.g-LPS), a key virulence factor in periodontitis, contributes to systemic vascular diseases, notably atherosclerosis. MicroRNA-21 (miR-21), a critical post-transcriptional regulator, influences inflammation and vascular pathology, but its…
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Small RNA sequencing in individually selected sperm: Biomarkers for male subfertility and predictors of pregnancy success
Background: Sperm quality defined by motility and morphology has critical implications for fertility and pregnancy outcomes. Small RNAs, including microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs), play regulatory roles and may reflect underlying sperm function. This study aimed to identify…
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ncFN: a comprehensive non-coding RNA function annotation framework based on a global and heterogeneous biomolecular network
Increasing evidence indicates that non-coding RNAs (ncRNAs) have emerged as essential factors in most biological processes through diverse mechanisms. However, the biological functions of most ncRNAs are still poorly understood. Here, we developed ncFN, a novel and comprehensive framework for ncRNA…
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Artikel Jurnal
circMRPL35 promotes gastric cancer progression through the miR-6809-3p/ZNF90 axis and affects the EMT process and TGF-β1/SMAD2/3 signaling
Background: Circular RNAs (circRNAs) have been implicated in developing gastric cancer (GC). However, the role of circMRPL35 in GC remains unknown. Methods: This study identified differentially expressed circMRPL35 using gene expression profiles GSE78092, GSE131414, and GSE100170. RNA R enzyme and…
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LncRNA-EME1 enhances BRCA1 recruitment and alters repair of DNA damage in cervical cancer radioresistance
Background: Cervical cancer is a significant cause of mortality in women globally, and radioresistance limits the effectiveness of standard radiotherapy treatment. Exploring the molecular mechanisms that contribute to radioresistance is vital for improving therapies. This study focuses on the role…
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Long non-coding RNAs in B-cell acute lymphoblastic leukemia: Disease implication, challenges and therapeutic opportunities
B-cell acute lymphoblastic leukemia (B-ALL) manifests as an abnormal proliferation of neoplastic B-cell lymphocytes, adversely affecting both children and adults. Despite the advancements in cancer research, B-ALL cure remains challenging due to the complexity of the disease and immense subtype…
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AQUARIUM_HB: a bioinformatics pipeline for human blood circular RNA analysis
Accurately identifying and quantifying human blood circular RNAs (circRNAs) from RNA-seq data is a critical bioinformatics challenge in biomarker discovery for human diseases. In this study, we present AQUARIUM-HB, a comprehensive bioinformatics pipeline for identifying, quantifying, annotating…
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Illustration of the variable 1D sequences but conserved 2D and 3D structures of different ncRNA nanostructures for tracking the evolution and origin of organisms
Viruses and other microorganisms are constantly mutating and emerging in different regions. Here, we apply nanotechnology to examine the primary, secondary, and tertiary structures of novel noncoding RNA nanoparticles and find that primary sequences (1D) vary widely between viruses, while secondary…
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Non-coding RNAs in congenital heart disease and placental development: Bridging molecular mechanisms to clinical biomarkers and therapies
Non-coding RNAs (ncRNAs) have emerged as pivotal regulators of gene expression, orchestrating embryonic development and disease pathogenesis. This review synthesizes current knowledge on the origin, biogenesis, and functional diversity of ncRNAs, with a focus on their regulatory crosstalk in…
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Circadian rhythm-related miR-6883-5p suppresses enzalutamide-resistant prostate cancer
The increasing incidence of prostate cancer (PCa), particularly the emergence of treatment-resistant castration-resistant prostate cancer (CRPC), has intensified research efforts to address this lethal disease. Circadian rhythm gene alterations have been identified as critical factors influencing…
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circNLK restrains glioblastoma malignancy by binding to hnRNP L and destabilizing RGS16
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, underscoring the need to identify tumor-suppressive regulators for the development of more effective therapies. Circular RNAs (circRNAs) have emerged as important regulators in cancers, yet their roles in GBM remain…
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Vitamin E promotes dermal papilla cell proliferation via the lncRNA2919/STAT1 axis to activate the Hedgehog signaling pathway
Hair-follicle development is a key determinant of the quality and yield of Angora rabbit wool. Vitamin E (VE) has antioxidant properties and regulates cell proliferation. However, the molecular mechanism by which VE regulates hair-follicle growth is unclear. This study investigated the effects of…
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The pachytene-specific lncRNA 1700008K24Rik is essential for mouse spermatogenesis and functions as a conserved piRNA precursor
Spermatogenesis is a complex differentiation process requiring precise spatiotemporal gene regulation, yet the functions of most testis-enriched long noncoding RNAs (lncRNAs) remain elusive. Here, we identify 1700008K24Rik as a pachytene-specific lncRNA that is essential for mouse spermatogenesis…
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Targeting non-coding RNAs in the ferroptosis system: Molecular mechanisms and clinical translation for reversing doxorubicin resistance in breast cancer
Breast cancer remains one of the leading causes of cancer-related morbidity and mortality in women worldwide, and the clinical efficacy of doxorubicin (DOX) is frequently compromised by chemoresistance. Ferroptosis, an iron-dependent form of regulated cell death characterized by excessive lipid…
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Discovery of a G-rich ultra stable human ncRNA G-quadruplex that binds ATP
Thermostable RNA motifs have been shown to be a unique material for building nanoparticles for many applications (Guo lab, Nature Nanotechnology, 2020 PMID: 21102465; 2021 PMID: 21909084). Here, we report the discovery of a G-rich ultra-stable human ncRNA G-quadruplex that binds ATP with a strong…