1.437 hasil
Menampilkan 1–20 · 0,40 detik · RSS
Pediatric Hematology Oncology Journal
Scopus
ISSN 2468-1245 · Elsevier · 1.437 artikel di indeks
-
Artikel Jurnal
Hemoglobin SC disease and its clinical manifestations in pediatric patients: where is the data?
Hemoglobin SC Disease is among the main hemoglobinopathies related to sickle cell anemia (only surpassed in prevalence by Hemoglobin SS Disease). Although considered a pathology of lesser severity and complications, information on its clinical manifestations seem to lack support in consistent…
-
Artikel Jurnal
Induction chemotherapy followed by arsenic and all-trans retinoic acid for acute promyelocytic leukemia: Outcomes from a single-center protocol in Singapore
KKH-APML 17 is a single-center protocol for the treatment of pediatric acute promyelocytic leukemia (APML) in Singapore, which commences with standard induction chemotherapy followed by arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for consolidation. It was designed to reduce…
-
Artikel Jurnal
Parental experience of hemophilia diagnosis disclosure in Morocco: a mixed-methods study on communication quality and psychosocial impact
Background: Disclosure of a haemophilia diagnosis in paediatric settings is a critical moment that shapes parental understanding, emotional adjustment, and long-term engagement in care. In Morocco, where healthcare resources are constrained and cultural factors strongly influence family dynamics…
-
Artikel Jurnal
Pharmacogenetic variants and treatment-related toxicity during consolidation therapy in a child with Down syndrome-associated acute lymphoblastic leukemia: a case report
Background: Children with Down syndrome-associated acute lymphoblastic leukemia (DS-ALL) are vulnerable to chemotherapy-related toxicity, including methotrexate toxicity. Pharmacogenetic variation in folate and methotrexate pathway genes may contribute to interindividual variability, but evidence…
-
Artikel Jurnal
Venetoclax–azacitidine as a bridge to transplant in pediatric relapsed/refractory acute myeloid leukemia: A real-world experience
Background: Survival outcomes in pediatric acute myeloid leukemia (AML) have improved significantly; however, prognosis for relapsed or refractory (R/R) disease remains dismal. This study evaluates real-world outcomes of Venetoclax-Azacytidine (Ven–Aza) as a bridge to transplant in children with…
-
Artikel Jurnal
Pediatric idiopathic multicentric Castleman disease presenting with massive ascites and pleural effusions
Castleman disease is a rare lymphoproliferative disorder with varying clinical presentations. In pediatric populations, the incidence of idiopathic multicentric Castleman disease (iMCD) is exceedingly rare, with literature limited to isolated case reports and case series. Herein, we describe a…
-
Artikel Jurnal
Nutritional status during initial childhood cancer treatment: A retrospective cohort study
Background: Malnutrition is a common problem in pediatric oncology. However, most studies only measure weight at diagnosis and the end of treatment, missing the critical early period. This study aimed to track month-by-month nutritional changes during the first 60 days of chemotherapy to identify…
-
Artikel Jurnal
Tumor volume reduction after neoadjuvant chemotherapy in childhood nephroblastoma: radiological, histopathological, and clinical correlates in Tanzania
Background: Nephroblastoma is the most common pediatric kidney cancer, accounting for approximately 6% of childhood malignancies. Neoadjuvant chemotherapy plays an important role in reducing tumor size and facilitating safer surgery. This study aimed to determine radiological tumor volume reduction…
-
Artikel Jurnal
Patterns of pain management in pediatric oncology patients: Experience from a tertiary care center in Pakistan
Background: Pain is one of the most distressing symptoms in children with malignancies, yet pediatric palliative care (PPC) services in low- and middle-income countries (LMICs) remain underdeveloped. In Pakistan, gaps in physician training, opioid underprescribing, and healthcare worker and…
-
Artikel Jurnal
Self reported quality of life, problems faced, and their management strategies among children with leukemia undergoing chemotherapy: A descriptive study
Background: The survival in childhood acute lymphoblastic leukemia (ALL) is increasing, however, self-reported quality of life is underreported in low- and middle-income countries (LMICs) such as India, compared to high-income countries. The current study is undertaken to comprehensively assess…
-
Artikel Jurnal
Nutritional care practice status in Pediatric oncology units in low-and middle-income countries: A Scoping Review
Introduction: Malnutrition is pervasive among pediatric cancer patients in low- and middle-income countries (LMICs). The survival rate of this population is far lower in LMICs than in high-income country (HICs), which in part is related to poor nutritional care. However, the status of nutritional…
-
Artikel Jurnal
Chemotherapy-induced hepatotoxicity in children with acute lymphoblastic leukemia during the maintenance and post-treatment phases: A prospective cohort study from south Iran
Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, accounting for 23% of pediatric malignancies worldwide. In Iran, the cumulative incidence is approximately 21 cases per 100,000 children under 15, with a five-year survival rate of 67%. Maintenance-phase…
-
Artikel Jurnal
Familial acute myeloid leukemia with germline CEBPA mutation in a Syrian family: successfully treated with allogeneic hematopoietic stem cell transplantation
Background: Familial acute myeloid leukemia (AML) associated with germline CEBPA mutations is a rare autosomal dominant disorder. Early recognition and genetic testing are essential for diagnosis, management, and donor selection in affected families. Case presentation: We report a Syrian family…
-
Artikel Jurnal
Bortezomib as plasma cell – directed therapy in pediatric refractory autoimmune haemolytic anaemia: A report of two cases
Background: Paediatric autoimmune haemolytic anaemia (AIHA) is a rare but potentially life-threatening disorder. The clinical course ranges from acute, self-limiting episodes to chronic, relapsing disease. First-line therapy with corticosteroids works in most cases but some patients relapse and…
-
Artikel Jurnal
A Wolf in Sheep's clothing: Mastocytosis lurking under favorable risk AML
Background: Systemic Mastocytosis associated with hematologic neoplasms (SM-AHN) is exceedingly rare in children posing a diagnostic and therapeutic challenge. Case report: We report a 5-year-old girl with AML-M2 with RUNX1:RUNX1T1 and mutations in ASXL1 and NRAS. After the first cycle of…
-
Artikel Jurnal
Constitutional mismatch repair deficiency syndrome: Clues from the clinic, proof in the genes
Background: Constitutional mismatch repair deficiency (CMMRD), a rare autosomal recessive cancer predisposition syndrome, is characterized by neurocutaneous stigmata and early-onset aggressive multisystem malignancies. Data from low and middle-income countries is limited. Case series: Eight…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.