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Cancer Treatment and Research Communications
Scopus
ISSN 2468-2942 · Elsevier · 1.156 artikel di indeks
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Artikel Jurnal
OTUB1/SLC7A11 axis promoted AKT signaling activation to mediate ovarian cancer progression
Purpose: OTUB1 functions as a deubiquitinating enzyme (DUB) and has been reported to be associated with tumor progression. This study aimed to investigate the role of OTUB1 signaling in ovarian cancer progression. Materials and Methods: Twenty-five patients diagnosed with ovarian cancer were…
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Artikel Jurnal
Prognostic value of the baseline triglyceride-glucose-body mass index in small cell lung cancer undergoing chemoimmunotherapy: A multicenter retrospective study
Background: The prognostic role of the triglyceride-glucose-body mass index (TyG-BMI), a surrogate marker for insulin resistance, in small cell lung cancer (SCLC) patients treated with immune checkpoint inhibitors remains undefined. Methods: In this multicenter retrospective study, SCLC patients…
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Artikel Jurnal
Synergistic regulation of tumor angiogenesis via flavonoid modulation of lncRNAs: Mechanistic insights and therapeutic potential
Angiogenesis is a hallmark process of tumor growth, metastatic progression, and therapeutic resistance. The role of long noncoding RNAs (lncRNAs) in the regulation of angiogenesis has emerged as a critical factor influencing cancer progression. Flavonoids are natural polyphenolic compounds known…
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Artikel Jurnal
Characterization of POU2F3-expressing large cell neuroendocrine carcinoma of the lung: A comprehensive analysis of morphology, immunohistochemistry, and genomic alterations
Large cell neuroendocrine carcinoma (LCNEC) is a neuroendocrine carcinoma (NEC) of the lung that is characterized by its heterogeneous morphology, diverse immunophenotypes, and complex genomic profiles. Among LCNECs, a subset expressing the transcription factor POU2F3 (LCNEC-P) has been suggested…
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Artikel Jurnal
Comprehensive clinical characteristics and outcomes of stage IV EGFR-mutant NSCLC based on PD-L1 expression
Epidermal growth factor receptor (EGFR) and programmed death ligand 1 (PD-L1) are cell surface proteins that interact in the context of immune evasion to promote cancer growth. Associations between PD-L1 expression level and clinico-pathologic features of EGFR mutated (EGFR-mt) non-small cell lung…
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Artikel Jurnal
Clinical characteristics and survival outcomes of young women with luminal HER2-low and HER2-ultralow breast cancer
Background: Young women with breast cancer (YWBC) often present with aggressive, hormone receptor-positive tumors. However, the implications of HER2-low and HER2-ultralow expression in this group have not been well characterized despite their potential therapeutic relevance. Methods: We conducted a…
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Artikel Jurnal
LRRC15 in tumorigenesis, progression, and therapy
Leucine-rich repeat-containing protein 15 (LRRC15), a transmembrane protein, has been closely associated with malignant phenotypes, therapeutic resistance, and immune evasion in various solid tumors since its initial identification as a tumor-associated antigen in 2003. This review systematically…
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Artikel Jurnal
Chemotherapy-induced liver injury in Tibetan breast cancer patients: clinical features and risk factor analysis
Objective: To conduct the first analysis of the clinical characteristics and factors affecting drug-induced liver injury following neoadjuvant and adjuvant chemotherapy for breast cancer in the Xizang region. Methods: Overall, 246 patients with breast cancer diagnosed and treated at the People's…
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Artikel Jurnal
Phase 1/2 trial of brigatinib plus panitumumab in patients with osimertinib-resistant EGFR-mutated non-small cell lung cancer harboring EGFR C797S mutation
Background: Osimertinib is a standard treatment for advanced EGFR-mutated non-small cell lung cancer (NSCLC). The EGFR C797S mutation is one of the most common resistant mechanisms to osimertinib. Based on our preclinical data, the safety and efficacy of brigatinib combined with panitumumab was…
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Artikel Jurnal
Efficacy and safety of first-line EGFR-TKI combined with chemotherapy versus EGFR-TKI monotherapy in patients with EGFR-mutant non-small cell lung cancer and liver metastases: A propensity score–matched analysis
Introduction: Liver metastasis (LM) confers a poor prognosis in patients with epidermal growth factor receptor (EGFR)–mutant non–small cell lung cancer (NSCLC). Although EGFR tyrosine kinase inhibitors (TKIs) are the standard first-line treatment, the optimal approach for this high-risk subgroup…
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Artikel Jurnal
Renal function decline after radical nephroureterectomy: Longitudinal analysis and predictive factors in upper tract urothelial carcinoma
Objective: To evaluate renal function trends following radical nephroureterectomy (RNU) and identify key preoperative predictors of post-RNU renal function in patients with upper tract urothelial carcinoma (UTUC). Methods: This retrospective study analyzed 338 UTUC patients who underwent RNU…
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Artikel Jurnal
Metabolic signatures and predictive biomarkers of liposomal doxorubicin-induced hypersensitivity in breast cancer: A pilot study
Background: Liposomal doxorubicin hypersensitivity significantly affects breast cancer patients, with widely varying incidence rates (9 % to 46 %). Despite its efficacy, this condition poses a critical barrier to treatment due to the need for precise patient management and the absence of effective…
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Artikel Jurnal
RAS-variant allele frequency as a potential prognostic marker of overall survival in patients with metastatic colorectal cancer
Background: Presence of RAS mutations in mCRC are negatively correlated with OS. NGS enables detailed information regarding the heterogeneity of RAS mutations including specific amino acid changes as well as variant allele frequency (VAF). Recently, VAF has been postulated to have a role in…
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Artikel Jurnal
Coconut milk exosomal formulation of curcumin analog targets head and neck cancer progression through alterations in the HABP1 signaling mechanism
Background: Head and neck cancer (HNC) is a malignancy characterized by uncontrolled cell growth with increasing incidence rates and heterogeneity. Hyaluronan binding protein 1 (HABP1) is a glycoprotein that acts as a cell surface marker, influencing the immune tumor environment, and is…
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Artikel Jurnal
Non-Coding RNAs in breast cancer bone metastasis: Regulators and novel therapeutic targets
Bone metastasis is one of the most common complications in patients with advanced breast cancer, severely impairing quality of life and significantly increasing the risk of mortality. This process is driven by complex interactions between tumor cells and the bone microenvironment, where non-coding…
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Artikel Jurnal
Application of landmark analysis and piecewise Cox regression to identify features associated with prognosis: A national retrospective cohort study of New Zealand women
Background: Breast cancer prognosis changes over time in complex ways depending on individual risk factors. This study aimed to analyze how breast cancer outcomes in New Zealand women change over time and identify features associated with breast cancer specific survival and locoregional recurrence…
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Artikel Jurnal
Treatments and survival outcomes of patients with synchronous and metachronous metastatic bladder cancer: A population-based nationwide cohort study
Objective: To describe and compare clinicopathological characteristics, treatment patterns and overall survival outcomes of contemporary patients diagnosed with synchronous (smBC) or metachronous metastatic bladder cancer (mmBC) in the Netherlands. Methods: All patients newly diagnosed with bladder…
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Artikel Jurnal
Dual-jet transition cold atmospheric plasma suppresses colon cancer stem cells via matrix metalloproteinase regulation
Colon cancer stem cells (CCSCs) are critical drivers of tumor progression, metastasis, and therapeutic resistance, largely mediated by matrix metalloproteinases (MMPs). This study investigates the therapeutic potential of a novel dual-jet transition cold atmospheric plasma (DJTCAP) system to…
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