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Pathogens and Immunity
Scopus
ISSN 2469-2964 · Case Western Reserve University · 229 artikel di indeks
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Artikel Jurnal Teks lengkap
A Novel Adaptive Platform for Rapid, Simple Flow-Based Antibody Detection Devices Predicts NAb Levels to SARS-CoV-2
Background: COVID-19 has caused millions of deaths and continues to burden individuals and the healthcare system. Antibodies that neutralize SARS-CoV-2 have proven to be the most reliable markers of immune protection, targets for vaccine development, and approaches for anti-viral antibody-based…
Juga tersedia di: DOAJ
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Characterization of Distinct Monocyte Subtypes and Immune Features Associated with HIV, Tuberculosis, and Coronary Artery Disease in a Ugandan Cohort Using Mass Cytometry
Background: Coronary artery disease (CAD), tuberculosis (TB), and HIV are major global health concerns. Individuals affected by one or more of these conditions often exhibit chronic inflammation and immune dysregulation, with monocytes playing a central role. Monocyte subsets are known to expand in…
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Gastrointestinal Mucosal Disruptions During ART-Treated SIV/Plasmodium fragile Co-Infection
Background: Human immunodeficiency virus (HIV) and Plasmodium spp., which causes malaria, are co-endemic. Previously, we showed that during antiretroviral therapy (ART)-treated simian immunodeficiency virus (SIV)/Plasmodium fragile co-infection, peripheral markers of neutrophil extracellular trap…
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2025 Conference on Bacteriophages: Biology, Dynamics, and Therapeutics
The 2025 Conference on Bacteriophages: Biology, Dynamics, and Therapeutics, supported by the International Antiviral Society–USA, brought over 250 researchers, clinicians, and industry innovators from 17 countries to Washington, DC, from October 12 – 14, 2025. The meeting emphasized collaboration…
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Eating Away at Antibiotic Resistance – Is Phage Therapy Our Future?
This editorial provides a brief background on over a century of research on bacteriophages, which led to the inaugural 2025 Conference on Bacteriophages: Biology, Dynamics, and Therapeutics, supported by the IAS–USA. A summary of this meeting is included in this issue of Pathogens and Immunity and…
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Distinct Antibody Fc-profiles in Lymph During Homeostasis and Chronic HIV Infection
Background: Antibodies play a critical role in the control of pathogens and tumors through their ability to recognize non-self and then direct immune-mediated destruction. Antibodies are generated by plasma cells or plasmablasts, located throughout the tissues, and are transported between blood…
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Historical Highlight: Three Seminal Articles Relating to the Recognition of Protein Antigens by Antibodies
Beginning with this installment, the Pathogens and Immunity Historical Highlight series will focus, at least in some instances, on important themes in immunology, infectious disease, and microbiology by summarizing the contributions of a small and highly selected sampling of foundational articles…
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A Year in Review on Tuberculosis and Non-tuberculous Mycobacteria Disease: A 2026 Update for Clinicians and Scientists
Background: Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide, while infections from non-tuberculous mycobacteria (NTM) represent a growing public health threat. In its 20th year of activity, the Tuberculosis Network European Trials group (TBnet; www.tbnet.eu) is one of…
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NF-κB/OCT-1 Mediated Upregulation of CXCL14 Chemokine Mobilizes Mucosal Effector Memory CD44+CD62L-CD4+ and CD8+ TEM Cells, and NK Cells Associated with Protection Against Genital Herpes
Background: Mucosal chemokines (eg, CCL25, CCL28, CXCL14, and CXCL17) play key roles in protecting mucosal surfaces against invading infectious pathogens. However, their specific contributions to protection against genital herpes remain to be fully elucidated. Here, we investigated the role of…
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Keystone Epitope Theory: An Ecological Perspective on RNA Viruses, Tumor Immunoediting, and Vaccine Design
We propose that persistent, human-adapted DNA organisms shape postnatal immunity by focusing responses on functionally constrained epitopes within tissue niches. Here, we examine rapidly evolving RNA viruses and tumors through that lens. We propose that their persistence is promoted by 2 coupled…
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Keystone Epitope Theory: Implications for Hypersensitivity, Autoimmunity, and Transplantation
HLA class I alleles confer a striking risk for T cell–mediated drug hypersensitivity, yet positive predictive values are low—typically under 10% and as low as 0.12% for some drug–HLA pairs. We propose that persistent, human-adapted pathogens—notably herpesviruses—focus postnatal immune memory on…
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Heterogeneity of Airborne Virus Transmission in the Built Environment: A Narrative Review
The COVID-19 pandemic accelerated recognition of airborne transmission of respiratory infections. Despite improved mechanistic understanding, our ability to predict the risk of infection in a given scenario remains limited owing, in part, to high heterogeneity in factors involved in transmission…
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Systemic Evaluation of Administered FITC-Dextran or Evans Blue Dye to Determine Intestinal Barrier Permeability in Nonhuman Primates
Background: Microbial translocation is a key contributor to chronic immune activation during HIV infection. Current methods of measuring microbial translocation are limited in sensitivity and are largely indirect, underscoring the need for more precise and direct techniques that can be followed…
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Mast Cells Control the Bacterial Burden and Grain Formation in Murine Experimental Actinomycetoma Induced by Nocardia brasiliensis
Background: The immunopathogenesis of actinomycetoma, a chronic granulomatous infection caused primarily by Nocardia brasiliensis, involves poorly defined mechanisms sustaining its characteristic cyclical inflammation. Methods: Using MCdeficient KitW-sh/W-sh mice, this study investigated the role…
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Impact of Sex on Viral Shedding and Symptom Severity During Acute COVID-19
Background: To evaluate the impact of sex on acute SARS-CoV-2 infection, 668 participants from the ACTIV-2/A5401 study were followed over a 28-day period. Methods: A primary analysis was performed on 469 participants with quantifiable viral loads at baseline. Results: Male and female participants…
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Eric Topol, MD, Discusses Longevity, AI, and Evidence-Based Medicine
In this interview, Eric Topol, MD, reflects on a career defined by a sustained commitment to patient‑centered medicine. He describes his early training in cardiology, mentorship grounded in a humanistic approach, and how adaptability has shaped his evolving scientific focus. Dr. Topol emphasizes…
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Long-Term Follow-Up After Fecal Microbiota Transplantation via Freeze-Dried Capsules for Recurrent Clostridioides difficile Infection
Background: Fecal microbiota transplantation (FMT) is a standard therapy for recurrent Clostridioides difficile infection (CDI). Limited information is available on the durability of response after FMT via freeze-dried oral capsules and on whether patients who fail an initial FMT can be…
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Artikel Jurnal Teks lengkap
Hypervirulent Klebsiella pneumoniae (hvKp): Overview, Epidemiology, and Laboratory Detection
Klebsiella pneumoniae (Kp) is a Gram-negative pathogen responsible for both hospital- and community-acquired infections. Kp is classified into 2 distinct pathotypes: classical K. pneumoniae (cKp) and hypervirulent K. pneumoniae (hvKp). First described in Taiwan in 1986, hvKp are highly pathogenic…
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Stanley Plotkin, MD, Discusses Scientific Progress and the Complexities of Public Health Vaccine Policy
Stanley Plotkin, M.D., reflects on his professional journey, describing how formative educational experiences influenced his career. He discusses his contributions to vaccine development, notably for rubella and rotavirus, and shares insight on advancements in vaccine technology, including…