898 hasil
Menampilkan 1–20 · 0,17 detik · RSS
Hepatology Communications
Scopus
ISSN 2471-254X · Wolters Kluwer Health/LWW · 898 artikel di indeks
-
Artikel Jurnal
A multinational survey assessing the impact and burden of pruritus on patients with primary sclerosing cholangitis
Background:. Pruritus is a common primary sclerosing cholangitis (PSC) symptom that greatly impacts quality of life (QoL; sleep, fatigue) and, in severe cases, may be an indication for liver transplantation. Currently, there are no effective pruritus treatments for PSC. This survey focuses on the…
-
Artikel Jurnal
Development of retrieval-augmented generation–based large language model for drug-induced liver injury using Livertox data
Background:. Idiosyncratic DILI is a complex clinical challenge requiring timely and accurate decision support. LiverTox, curated by the National Institute of Health (NIH), offers a comprehensive DILI evidence base, but its encyclopedia-like format hinders point-of-care use. Health care providers…
-
Artikel Jurnal
A systematic review of post-liver transplantation treatment and outcomes for late T-cell mediated, chronic ductopenic, and antibody-mediated rejection
Background:. Compared to the treatment for acute T-cell–mediated rejection, management of late T-cell–mediated rejection, chronic ductopenic rejection, and antibody-mediated rejection is more heterogeneous. Methods:. We conducted a systematic review of studies on the treatment of liver transplant…
-
Artikel Jurnal
Myosin 5b deficiency alters liver proliferation, zonation, and bile acid composition
Background:. Myosin 5b (Myo5b) is a motor protein critical for trafficking proteins to the apical surface of intestinal epithelial cells. Inactivating mutations in MYO5B cause microvillus inclusion disease (MVID), a congenital diarrhea disorder that often leads to liver cholestasis. While Myo5b’s…
-
Artikel Jurnal
AI-assisted, single-fiber digital pathology quantification of changes in liver fibrosis after bariatric surgery
Background:. In steatohepatitis trials, antifibrotic effects are measured by conventional histology, albeit with significant limitations. We assessed how artificial intelligence–assisted, single-fiber quantitative image analysis of hepatic fibrosis matrix measures fibrosis reversal following an…
-
Artikel Jurnal
Immune mechanisms and pathophysiology of T cell-mediated pediatric acute liver failure (TC-PALF)
Immune dysregulation in pediatric acute liver failure (PALF) is a distinct phenomenon that has garnered interest with respect to disease outcomes and targeted therapies. Some patients with PALF have an “indeterminate” (iPALF) etiology ranging from acute severe hepatitis to fulminant liver failure…
-
Artikel Jurnal
Symptom burden is associated with health-related quality of life in symptomatic adults with primary sclerosing cholangitis
Background:. The Primary Sclerosing Cholangitis Symptom Assessment Project (PSC-SAP) is a research initiative aimed at developing regulatory-grade PSC-specific symptom measures. During the initial screening phase for PSC-SAP, patient-reported symptom data were collected from a cohort of symptomatic…
-
Artikel Jurnal
A randomized trial of viral vector and adjuvanted protein HBV therapeutic vaccine in people with chronic hepatitis B on nucleos(t)ide analogs
Background:. This study assessed the safety, efficacy, and immunogenicity of a therapeutic immunization strategy aimed at reaching a functional cure for chronic hepatitis B (CHB), relying on a heterologous prime-boost with viral vectors ChAd155-hIi-HBV and MVA-HBV, combined with sequential or…
-
Artikel Jurnal
The INTEGRATE prospective cohort study: Design and methods to evaluate biopsychosocial determinants of outcomes in early liver transplantation for alcohol-associated liver disease
Background and Aims:. Early liver transplantation (eLT) for alcohol-associated liver disease (ALD), defined as transplant evaluation with
-
Artikel Jurnal
The rate of and risk factors for falls among patients with cirrhosis: A multicenter study
Background:. Falls are associated with frailty and are a significant cause of morbidity among the elderly. Due to accelerated physiologic aging, frailty is common among patients with cirrhosis. We sought to identify the patients with cirrhosis at highest risk of falling and to explore the…
-
Artikel Jurnal
Effects of diabetes, obesity, and metabolic syndrome on alcohol-associated liver disease: A systematic review
Background:. Alcohol-associated liver disease (ALD) is a leading cause of advanced liver disease and liver transplantation worldwide. Cardiometabolic risk factors (CMRFs) may worsen ALD prognosis. While recent nomenclature acknowledges the impact of CMRFs in steatotic liver disease with…
-
Artikel Jurnal
Artificial intelligence predicts recurrent autoimmune hepatitis after liver transplantation in a multicenter cohort study
Background: . Autoimmune hepatitis (AIH) is an important indication for liver transplantation (LT), but recurrence affects over 30% of recipients, threatening long-term survival. Current strategies to prevent recurrence and progressive graft fibrosis remain suboptimal, with limited evidence to…
-
Artikel Jurnal
Global multicenter validation of noninvasive fibrosis assessment pathways in MetALD and ALD
Background:. Noninvasive tests are well validated in metabolic dysfunction–associated steatotic liver disease, but evidence in metabolic dysfunction and alcohol-associated liver disease (MetALD) and alcohol-associated liver disease (ALD) is limited. We evaluated noninvasive test–based clinical care…
-
Artikel Jurnal
The risk of cardiovascular events in metabolic dysfunction–associated steatotic liver disease according to fibrosis stage and diabetes status: A cohort study
Background:. Atherosclerotic cardiovascular disease (ASCVD) is a major cause of morbidity and mortality in metabolic dysfunction–associated steatotic liver disease (MASLD). We investigated whether fibrosis severity assessed using guideline-recommended noninvasive liver fibrosis pathways was…
-
Artikel Jurnal
Spatial transcriptomics supports a role for SOX4-driven signaling throughout the disease course of biliary atresia
Background:. Biliary atresia (BA) is a neonatal fibroinflammatory cholangiopathy of infancy and the most common indication for pediatric liver transplantation. We aimed to define the molecular mechanisms responsible for differences in the rate of disease progression among children with BA…
-
Artikel Jurnal
The contemporary epidemiology, causes, and management of drug-induced liver injury
Drug-induced liver injury is an important cause of clinically significant liver disease. In Western countries, antibiotics are the leading cause of DILI, with amoxicillin–clavulanate and trimethoprim–sulfamethoxazole most frequently implicated. Herbal and dietary supplements (HDS) are increasingly…
-
Artikel Jurnal
LECT2 deficiency contributes to bile acid metabolic reprogramming and cholestatic liver injury
Background:. Cholestatic liver injury involves impaired bile acid (BA) formation or flow, leading to toxic hepatic BA accumulation, yet the underlying mechanisms remain poorly understood. Leukocyte cell-derived chemotaxin 2 (LECT2) has been implicated in liver metabolic disorders; however, its…
-
Artikel Jurnal
Increased thrombin generation is linked to first hepatic decompensation in patients with compensated cirrhosis
Background: . Coagulation alterations may contribute to cirrhosis progression. We explored whether increased thrombomodulin-modified thrombin generation (TM-TG) was associated with first hepatic decompensation in compensated cirrhosis. Methods:. We retrospectively analyzed a prospectively collected…
-
Artikel Jurnal
Cost-effectiveness of HES V2.0 and GALAD for hepatocellular carcinoma surveillance in patients with cirrhosis
Background: . Ultrasound-based surveillance for HCC is limited by suboptimal sensitivity and low adherence. Blood-based biomarkers are potential alternatives for routine HCC surveillance. We aimed to define optimal sensitivity, specificity, and cost parameters under which blood-based biomarkers…