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APL Bioengineering
Scopus
ISSN 2473-2877 · AIP Publishing LLC · 595 artikel di indeks
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Artikel Jurnal Teks lengkap
Enhancing upper limb motor recovery prediction after acute stroke using EEG and subacute data
Electroencephalography (EEG) has shown promise in assessing and monitoring functional recovery in stroke survivors, but its utility in predicting upper limb motor recovery in a data-driven framework remains underexplored. This study presents a novel EEG-based machine-learning model, StrokeRecovNet…
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Synthetic mucus biomaterials enable localized therapeutic antibody delivery in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic condition characterized by recurrent gastrointestinal inflammation that requires long-term therapeutic intervention. While anti-TNF-α monoclonal antibodies (mAbs) are effective in maintaining remission in IBD, systemic delivery is associated with…
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Computational modeling of human vagus nerve stimulation with three-dimensional fascicular morphology
Implanted vagus nerve stimulation is FDA-approved to treat epilepsy, depression, and stroke sequelae and is under development for other disorders such as heart failure and rheumatoid arthritis. Anatomically realistic computational models enable the design of electrodes and stimulation parameters…
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Hypoxia-induced drug-resistance bias 3D cancer spheroid drug screens
Cellular 3D cancer spheroid technologies are novel tools that facilitate large-scale drug screening to bridge the in vitro–in vivo gap, without the cross-species effects of animal models. However, many spheroid studies fail to achieve IC50 (dosage for 50% inhibition) even for unreasonably high…
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Dose-optimized HILT promotes peripheral nerve repair through BMP4-Smad9-mediated inhibition of neuroinflammation and oxidative stress
Evidence has shown that high-intensity laser therapy (HILT) may be beneficial for recovery after peripheral nerve injury (PNI). However, the optimized doses and effective mechanisms remain unclear. The present study sought to explore the effects of various doses of HILT on the recovery of nerve…
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A vertically integrated system for tracking and assessing cell-cycle-aware phenotypes under confinement
Quantitative cell biology often examines migration and cell-cycle (CC) progression separately, limiting insights into their interplay under spatial constraints. Here, we present a vertically integrated platform combining multiplexed fluorescent reporters for CC phases, actin, and tubulin with…
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Fat promotes growth and invasion in a 3D microfluidic tumor model of triple-negative breast cancer
Diet influences the levels of small molecules that circulate in plasma and interstitial fluid, altering the biochemical composition of the tumor microenvironment (TME). These circulating nutrients have been associated with how tumors grow and respond to treatment, but it remains difficult to parse…
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Closing the loop on glioblastoma: A roadmap toward developing bioelectronics for continuous monitoring of tumor state
Closed-loop bioelectronic devices offer a promising platform for responsive treatment to heterogeneous disease states. Glioblastoma, an aggressive form of brain cancer, has recently emerged as a focus of bioelectronic medicine through delivery of electrotherapies. This perspective article posits…
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Improving muscle recruitment via multi-electrode transcutaneous spinal cord stimulation using automated selectivity-driven algorithms
Spinal cord injury (SCI) severely impairs motor function and quality of life. Transcutaneous spinal cord stimulation (tSCS) has emerged as a promising non-invasive neuromodulation technique to restore voluntary motor function by engaging spinal circuits below the lesion. While standard tonic tSCS…
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New concept in wound infection management: From bacterial eradication to microbiome modulation
Wound infection represents a significant challenge in clinical practice. Traditional wound management, targeting sterility and relying on strategies of broad-spectrum bactericidal activity and antibiotic dependence, achieves partial infection control but induces severe complications, including…
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Biobased adhesive hydrogels for wound management and tissue repair: From materials to advanced applications
Effective tissue adhesion under wet and dynamic physiological conditions remains a major challenge in wound management and tissue repair. Conventional tissue adhesives often suffer from limited biocompatibility, inadequate wet adhesion, or lack of degradability, restricting their broader clinical…
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Mesenchymal stem cell membrane-coated kaempferol biomimetic nanoformulation for the treatment of atherosclerosis
Atherosclerosis and its complications are highly prevalent worldwide, and managing oxidative stress in endothelial cells to alleviate abnormal inflammatory damage is a critical therapeutic approach. Nanomedicine delivery systems offer promising solutions by overcoming the limitations of surgical…
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Cell shape and maturation impacts α-actinin-2 tension in iPSC-derived cardiomyocytes
The contractile activity of cardiomyocytes (CMs) critical to heart function emerges from the collective shortening of sarcomeres. However, how these sarcomeric forces are transmitted within CMs during this process remains poorly understood. Traction force microscopy has been used to measure overall…
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Engineering of a wireless single capacitive discharge conductivity-clamped gene electrotransfer probe for naked nucleic acid therapeutics
Pulsed electric field gene electrotransfer addresses the need for safe, directed “vector-free” delivery of DNA/mRNA therapeutics in deep tissue targets. We report the development of a disposable needle-type “electro-lens” probe for precision delivery of DNA/mRNA to tissues via translocation of…
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Activation of cGAS–STING axis by CO@OMVs promote macrophage mitophagy for CIRI treatment
This study investigates the effects of nanobody-engineered bacterial outer membrane vesicles (CO@OMVs) on cGAS–STING-associated signaling, macrophage mitophagy, and cerebral ischemia-reperfusion injury (CIRI). Following extraction and characterization of CO@OMVs, in vitro experiments in RAW 264.7…
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HB-EGF enhances collective cell migration via spatial coordination of traction
An important process in wound healing is re-epithelialization, wherein cells collectively migrate to cover the wounded area. Here, we investigate how cellular forces lead to the migration of an epithelial monolayer in a wound healing assay. We report that heparin-bound epidermal growth factor…
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Photobiomodulation outperforms ultrasound in reducing IL-1β-driven chondrocyte inflammation
Therapeutic ultrasound (US) and photobiomodulation (PBM) are promising treatment modalities for restoring articular cartilage. Owing to their different mechanisms of action, individual or combined stimulation may elicit different bioeffects on chondrocytes. This study aimed to evaluate the…
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Biomechanical stress unmasks a fibroblast-dependent hypercontractile-disarray phenotype in MYBPC3 truncation HCM
Hypertrophic cardiomyopathy (HCM) is commonly caused by pathogenic variants in the sarcomere, such as truncations in myosin-binding protein C (MYBPC3), yet clinical severity and adverse outcomes correlate poorly with genotype alone and are strongly influenced by fibrosis. We developed an engineered…
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Construction of 3D bioprinted colorectal cancer models and evaluation of their efficacy and drug sensitivity
Currently, preclinical research on colorectal cancer (CRC) lacks effective tumor models. In recent years, 3D bioprinted models have shown great potential in tumor model construction. This study used 3D bioprinting technology to establish a CRC extracellular matrix (ECM) model. Gradient…
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Instrumentalized 3D printed scaffolds enable bone regeneration and fracture healing monitoring in critical size bone defects
Critical size bone defects do not heal without surgical intervention, and the current methods of treatment lack long-term efficacy and patient satisfaction. Our lab has previously demonstrated the use of 3D printed scaffold mimicking biological tissue structure in the regeneration of large critical…