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Blood Advances
Scopus
ISSN 2473-9529 · Elsevier · 1.648 artikel di indeks
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Artikel Jurnal
Diagnostic criteria for NK cell large granular lymphocyte leukemia: validation through a multicentric international study
Abstract: Natural killer (NK) large granular lymphocytic leukemia (LGLL) is a rare lymphoproliferative disorder lacking definitive clonality markers, complicating diagnosis and distinction from reactive NK cell expansions. We previously proposed an NK clonality score with high diagnostic accuracy…
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Artikel Jurnal
Retreatment with R-CHOP–like therapy in patients with late relapse of diffuse large B-cell lymphoma
Abstract: Patients with diffuse large B-cell lymphoma (DLBCL) with late relapse (>2 years from diagnosis) may be treated with a second course of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone)–like therapy particularly if comorbidities preclude more intensive options…
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Artikel Jurnal
Germ line LCP1 mutations cause immunodeficiency with neutropenia, monocytopenia, lymphopenia, and defective cytokinesis
Abstract: Severe congenital neutropenia (SCN) is characterized by neutropenia, recurrent infections, and an increased leukemia risk. Multiple genetic defects that underlie SCN have been identified, but a genetic diagnosis is still lacking in a significant proportion of patients. In this study, we…
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Artikel Jurnal
Functional recovery of NK cells after T-cell replete haploidentical HSCT: delayed licensing and poor anti-acute myeloid leukemia activity
Abstract: Haploidentical allogeneic hematopoietic stem cell transplantation (h-HSCT) is increasingly used in patients lacking an HLA-matched donor. In this context, the combination of posttransplant cyclophosphamide (PTCy) and antithymocyte globulin (ATG) effectively prevents graft-versus-host…
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Artikel Jurnal
Zanubrutinib for the treatment of patients with del(17p) and/or TP53 CLL/SLL: analysis across clinical studies
Abstract: Patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who harbor del(17p) and/or tumor protein p53 (TP53) mutations represent a high-risk population with a historically poor prognosis. To assess zanubrutinib efficacy and safety outcomes in patients with CLL/SLL…
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Artikel Jurnal
Efficacy and safety of belumosudil as compared with best available therapy for the treatment of cGVHD in the United States
Abstract: Belumosudil was approved by the Food and Drug Administration in the United States for the treatment of relapsed/refractory chronic graft-versus-host disease (cGVHD) based on a randomized phase 2 trial comparing 2 belumosudil doses. The efficacy and safety of belumosudil vs the best…
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Artikel Jurnal
Intranasal fentanyl and impact of an emergency department pain protocol for sickle cell disease on hospitalization rates
Abstract: Sickle cell disease (SCD) is an inherited red blood cell disorder with significant complications, including vaso-occlusive crisis (VOC), the most common cause of emergency department (ED) visits and hospitalizations. Pain in children with SCD is often underestimated. We evaluated the…
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Artikel Jurnal
Primary and secondary stroke prophylaxis in children with sickle cell anemia: a meta-analysis
Abstract: We conducted a pooled analysis to evaluate the effectiveness of hydroxyurea (HU), chronic blood transfusion (CBT), myeloablative allogeneic hematopoietic stem cell transplant (HCT) with a matched related donor, and revascularization surgery (RVS) in children with sickle cell anemia (SCA)…
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Artikel Jurnal
Derivation and external validation of a venous thromboembolism risk prediction model in asparaginase-treated ALL
Abstract: The incidence of venous thromboembolism (VTE) in patients with acute lymphoblastic leukemia (ALL) receiving asparaginase-based induction is high despite primary thromboprophylaxis. Our aim was to derive and externally validate a VTE risk prediction model in patients with ALL receiving…
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Artikel Jurnal
Antibiotic risk score for acute graft-versus-host disease
Abstract: Certain antibiotic exposures have been associated with increased rates of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic cell transplant (alloHCT). Using data from 2023 alloHCTs performed at our center (2010-2021), we recently developed an antibiotic risk score…
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Artikel Jurnal
Efficacy and safety of vemircopan as monotherapy in patients with paroxysmal nocturnal hemoglobinuria
Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, complement-mediated hematologic disease. We present the results of a phase 2, open-label clinical trial of vemircopan monotherapy in patients with PNH to explore the efficacy and safety of inhibiting the complement alternative pathway…
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Artikel Jurnal
Heme and hemozoin induce platelet cell death through UPR-induced apoptosis and ferroptosis in vivax malaria
Abstract: Malaria is a highly prevalent infectious disease caused by Plasmodium parasites. Plasmodium intraerythrocytic replication leads to hemolysis-driven intermittent febrile crises in patients. In addition, the lysis of unparasitized red blood cells contributes to anemia and endotoxemia…
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