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British Journal of Biomedical Science
Scopus
ISSN 2474-0896 · Frontiers Media S.A. · 104 artikel di indeks
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Maternal Toxoplasma gondii Infection Perturbs Foetal and Maternal Foetal Interface Metabolism, Exposing the Foetus to Kynurenine
IntroductionToxoplasma gondii infection during pregnancy can result in abortion or congenital infection. Events in the maternal-foetal interface, which form a selective barrier between the maternal and foetal circulations and where critical immunological adaptations occur, are critical in…
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Investigating the Barriers Faced by Biomedical Science Undergraduates in Completing a Placement Year
IntroductionResearch shows completing a placement year is associated with improved academic and employment outcomes. For Biomedical science courses, pathology placements allow completion of the Institute of Biomedical Science (IBMS) registration training portfolio and obtaining Health and Care…
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Empowering Students to Identify Their Own Skill Sets Through a Final Year Biomedical Science Job Interview Assessment
IntroductionThe final year Professional Development for Biomedical Scientists module at Aston University strives to create competent practitioners upon graduation. Recent research identified that 93% of NHS pathology employers within the United Kingdom, do not believe that new Biomedical Scientist…
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Antimicrobial Resistance: The Answers
Antimicrobial resistance (AMR) has caused a global public health crisis, contributing to approximately five million deaths in 2019 and predicted deaths of approximately ten million annually by 2050. This equates to approximately 1.4-fold more deaths annually from AMR in 2050 than the entire…
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Breast Cancer Disparities in African and African-Ancestry Populations: Genetics, Epigenetics, Structural Barriers and Technology-Enabled Solutions
Breast cancer remains a leading cause of mortality among women globally, with disproportionately high incidence, aggressive subtypes and poor outcomes in African and African-ancestry populations. While inherited BRCA1/BRCA2 mutations drive hereditary risk, recent evidence highlights the critical…
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Assessing the Impact of Mesoporous, Co-Amorphous, and Polymer-Based Systems on Cefdinir’s Dissolution and Stability Via Predictive Modeling
The poor solubility and permeability of Biopharmaceutics Classification System (BCS) Class IV drugs pose major challenges to achieving sufficient oral bioavailability and therapeutic efficacy. Improving drug dissolution is a key strategy to enhance bioavailability, which in turn can enable more…
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High-Fat Diet Anticipates Age-Related Sarcopenia Through Increased Oxidative Stress and Inflammation
BackgroundAgeing, a physiological process, and obesity, a pathological condition, are both associated with several metabolic alterations including energy imbalance, altered body composition, chronic low-grade inflammation, lipotoxicity, glucotoxicity, insulin resistance and mitochondrial…
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An Analysis of the Career Pathway of Clinical Laboratory Scientists: Identifying Access Barriers and Best Practice to Increase Diversity in the Workforce
Widening participation among the clinical laboratory scientific workforce is essential to meet future needs of healthcare systems. The advantages of more diversity in this clinically pivotal workforce include better decision making, improved diagnostics and a wider pool of appropriately trained…
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Alternative Polyadenylation Signatures Distinguish Maladaptive Right Ventricular Remodeling in Pulmonary Hypertension: Implications for RNA-Based Diagnostics and Therapeutics
Increased pulmonary vascular pressures due to vascular remodeling, elevated vascular resistance, and vasoconstriction characterize Pulmonary Arterial Hypertension (PAH). The narrowing of the pulmonary arteries and obstruction of blood flow increase the Right Ventricular (RV) afterload, forcing the…
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REV-ERBs as regulators of circadian rhythm, neuroinflammation, and glial lipid homeostasis in Alzheimer’s disease. A narrative review
Alzheimer’s disease (AD) is characterized by progressive cognitive decline, amyloid-β and tau aggregation, and chronic neuroinflammation, processes that are tightly coupled to circadian and metabolic dysfunction. REV-ERBα (NR1D1) and REV-ERBβ (NR1D2) are ligand-dependent nuclear receptors that…
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Application of non-invasive preimplantation genetic screening for aneuploidy through spent embryo culture media analysis at 48 and 54 hours after embryo cleavage
BackgroundThis study aims to assess the effectiveness of non-invasive preimplantation genetic testing (niPGT) for detecting aneuploidy at two different time points, 48- and 54-hour following the cleavage stage of embryo development.MethodsA cohort of 15 infertile women was enrolled, involving a…
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Challenges and emerging strategies for genome-wide evaluation of loss of imprinting in cancer
Genomic imprinting is the phenomenon in which only a single allele of a gene is expressed based on its parental origin, thereby deviating from the typical biallelic expression of autosomal genes. It is meticulously controlled by epigenetic mechanisms, particularly DNA methylation. Imprinted loci…
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Training on PD-L1 scoring in non-small cell lung cancer with high intra- and inter-reader agreement: results of a worldwide microscopic/digital image-based training of 751 pathologists
Semi-quantitative scoring of PD-L1 expression on tumor cells (TCs) and/or infiltrating immune cells (ICs) is complex and requires expert pathologist training to reduce inter- and intra-reader variability. We conducted a 1- or 2-day training of 751 pathologists world-wide from 63 countries over a…
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Supporting quantitative skills in biomedical science with smart worksheets: intentions, impact and barriers to engagement
IntroductionThe growing diversity of university student populations highlights the critical need for inclusive support strategies. Student outcomes often remain linked to socio-economic factors and Level 3 qualifications, challenging universities to create equitable learning environments…
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Artificial intelligence approaches in biological age prediction: current status and challenges
Biological age (BA) prediction has emerged as a critical research frontier for evaluating individual health status and aging trajectories beyond chronological age (CA). Recent advances in artificial intelligence (AI) have substantially accelerated this field by enabling the integration and…
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Performance of a quality control center supporting national antimicrobial resistance surveillance
IntroductionEnsuring the reliability, standardization, and international comparability of antimicrobial resistance (AMR) surveillance data critically depends on the implementation of robust quality assurance frameworks. South Korea established the Korea Global Antimicrobial Resistance Surveillance…
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Immunohistochemical testing of GISTs using CD117 markers: the UK NEQAS ICC & ISH external quality assessment data show significant differences in the performance of methods in regular use
BackgroundCD117 (c-KIT) is a tyrosine kinase receptor protein, mutations in which are important in the tumourigenesis of gastrointestinal stromal tumour (GIST). Immunohistochemical detection of CD117 is the primary identifying feature in its diagnosis.IntroductionUK NEQAS ICC & ISH conducts an EQA…
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Evaluation of analytical performance of the Revvity sFlt-1 and PlGF methods for the assessment of preeclampsia
IntroductionThe measurement of the angiogenic biomarkers placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) are increasingly used to support the prediction and diagnosis of preeclampsia (PE) in routine clinical practice. There are an increasing number of methods…
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Concordance between crude extract and component allergens in a multiple allergen simultaneous test: a large-scale retrospective analysis
ObjectivesMultiple allergen simultaneous tests (MAST) increasingly incorporate both crude extract and molecular component allergens for specific IgE testing. However, systematic data on the diagnostic concordance between these two approaches remain limited. We evaluated the agreement between crude…